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Pulmonary Cell NewsAll Articles by Author:
Britya Ghosh
Endothelial Cell News
Breast Cancer Derived Exosomes Promoted Angiogenesis of Endothelial Cells in Microenvironment via circHIPK3/miR-124-3p/MTDH Axis
[Cellular Signalling] Scientists investigated the mechanisms underlying the angiogenesis in peripheral human endothelial cells mediated by the breast cancer (BC) cells derived exosomal circRNAs and aimed to explore the biomarkers for the anti-angiogenesis therapy for BC.
Endothelial Cell News
Perivascular Tenascin C Triggers Sequential Activation of Macrophages and Endothelial Cells to Generate a Pro-metastatic Vascular Niche in the Lungs
Scientists showed that specific secreted factors, induced in metastasis-associated endothelial cells, promoted metastasis in mice by enhancing stem cell properties and the viability of cancer cells.
[Nature Cancer] Full Article
Endothelial Cell News
SLC1A1-Mediated Cellular and Mitochondrial Influx of R-2-Hydroxyglutarate in Vascular Endothelial Cells Promotes Tumor Angiogenesis in IDH1-Mutant Solid Tumors
Scientists discovered that R-2-hydroxyglutarate produced by isocitrate dehydrogenase 1 (IDH1)-mutant tumor cells is preferentially imported into vascular endothelial cells and remodels mitochondrial respiration to promote tumor angiogenesis, conferring a therapeutic vulnerability...
Endothelial Cell News
Endothelial Cell-Specific Deletion of a microRNA Accelerates Atherosclerosis
Researchers examined the role of genetic deficiency of the miR-181b locus in endothelial cells during atherogenesis.
[Atherosclerosis] Abstract
Endothelial Cell News
Effects of Polystyrene Nanoplastics on Endothelium Senescence and Its Underlying Mechanism
Investigators assessed the possibility that nanoplastics exposure promoted premature endothelial cell (EC) senescence in porcine coronary artery ECs and, if so, to elucidate the underlying mechanism.
[Environment International] Full Article
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SMYD2-Methylated PPARγ Facilitates Hypoxia-Induced Pulmonary Hypertension by Activating Mitophagy
[Circulation Research] Pulmonary hypertension (PH) animal models were generated by treating mice/rats with chronic hypoxia for four weeks. SMYD2-vTg mice or wild-type rats and mice treated with LLY-507 were used to investigate the function of suppressor of variegation, enhancer of zeste, trithorax and myeloid Nervy DEAF-1 domain-containing protein 2 (SMYD2) on PH development in vivo.
PI3K/HSCB Axis Facilitates FOG1 Nuclear Translocation to Promote Erythropoiesis and Megakaryopoiesis
[eLife] Investigators identified heat shock cognate B as an indispensable protein for friend of GATA 1 (FOG1) nuclear translocation during erythropoiesis of K562 human erythroleukemia cells and cord-blood-derived human CD34+CD90+HSCs, as well as during megakaryopoiesis of the CD34+CD90+HSCs.
EVIDENCE Meta-Analysis: Evaluating Minimal Residual Disease as an Intermediate Clinical Endpoint for Multiple Myeloma
[Blood] This meta-analysis was based on the FDA guidance for considerations for a meta-analysis of minimal residual disease (MRD) as a clinical endpoint and evaluates MRD-negativity as an early endpoint reasonably likely to predict long-term clinical benefit.
