Bob

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Starvation Mediates Pancreatic Cancer Cell Sensitivity to Ferroptosis via ERK1/2, JNK and Changes in the Cell Mesenchymal State

[International Journal of Molecular Medicine] The authors examined the prospects of a novel approach to kill pancreatic cancer cells: Starvation combined with ferroptosis induction.

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The Interactive Role of Inflammatory Mediators and Metabolic Reprogramming in Pancreatic Cancer

[Trends in Cancer] Investigators focus on the interactive role of inflammatory signaling and metabolic reprogramming with emerging evidence of crosstalk, which supports the development, progression, and therapeutic resistance of PDAC.

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Cargo Receptor Surf4 Regulates Endoplasmic Reticulum Export of Proinsulin in Pancreatic β-Cells

[Communications Biology] Scientists demonstrated that Surf4, a cargo receptor homolog, regulated the endoplasmic reticulum (ER) export of proinsulin via its recruitment to ER exit sites

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RyR2/IRBIT Regulates Insulin Gene Transcript, Insulin Content, and Secretion in the Insulinoma Cell Line INS-1

[Scientific Reports] Insulin content, basal and 7.5 mM glucose-stimulated insulin secretion were reduced in RyR2KO and IRBITKO cells compared to controls.

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Terpenoids from Nardostachys jatamansi and Their Cytotoxic Activity against Human Pancreatic Cancer Cell Lines

[Phytochemistry] Compound epoxynardosinone exhibited significant cytotoxicity against CAPAN-2 cell lines with IC50 value of 2.60 ± 1.85 μM. 1-Hydroxylaristolone displayed comparable cytotoxicity on CFPAC-1 cell lines, compared to Taxol.

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Coix Seed Oil Regulates Mitochondrial Functional Damage to Induce Apoptosis of Human Pancreatic Cancer Cells via the PTEN/PI3K/AKT Signaling Pathway

[Molecular Biology Reports] Researchers investigated the possible mechanism of coix seed oil induction of pancreatic cancer cell apoptosis and regulating mitochondrial functional damage.

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Single-Cell Analysis of Anti-BCMA CAR T Cell Therapy in Patients with Central Nervous System Autoimmunity

[Science Immunology] Investigators performed single-cell multi-omics sequencing of paired cerebrospinal fluid and blood samples from patients with neuromyelitis optica spectrum disorder treated with anti–B cell maturation antigen (BCMA) CAR T cells.

Unveiling the Proteome-Wide Autoreactome Enables Enhanced Evaluation of Emerging CAR-T Therapies in Autoimmunity

[European Journal Of Clinical Investigation] Researchers leveraged advances in programmable-phage immunoprecipitation methodology to explore the modulation, or lack thereof, of autoantibody profiles, proteome-wide, in both health and disease.

Arming Vδ2 T Cells With Chimeric Antigen Receptors to Combat Cancer

[Clinical Cancer Research] Following a comprehensive overview of γδ T cell biology and innovative CAR engineering strategies, investigators discuss the clinical potential of Vδ2 CAR-T cells to overcome the current limitations of immunotherapy in solid tumors.

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