Bob

Newsletters

St13 Protects against Disordered Acinar Cell Arachidonic Acid Pathway in Chronic Pancreatitis

[Journal of Translational Medicine] St13, a co-chaperone protein, was investigated whether it constituted a novel regulatory target in chronic pancreatitis.

Newsletters

Rapid Acceleration of KRAS-Mutant Pancreatic Carcinogenesis via Remodeling of Tumor Immune Microenvironment by PPARδ

[Nature Communications] Investigators showed that peroxisome proliferator-activated receptor-delta (PPARδ), a lipid nuclear receptor, was upregulated in Pancreatic intraepithelial neoplasia lesions in humans and mice.

Newsletters

A p300/GATA6 Axis Determines Differentiation and Wnt Dependency in Pancreatic Cancer Models

[Journal of Clinical Investigation] Researchers performed in vivo CRISPR screens in PORCN inhibitor-sensitive RNF43-mutant pancreatic cancer xenografts.

Newsletters

HOXA10 Promote Pancreatic Cancer Progression via Directly Activating Canonical NF-κB Signaling Pathway

[Carcinogenesis] Immunohistochemistry assays were applied and demonstrated the relationship between HOXA10 expression and PDAC progression

Newsletters

SQLE Inhibition Suppresses the Development of Pancreatic Ductal Adenocarcinoma and Enhances Its Sensitivity to Chemotherapeutic Agents In Vitro

[Molecular Biology Reports] Scientists explored the function of seven important enzymes involved in cholesterol biosynthesis especially squalene epoxidase (SQLE) in PDAC therapy.

Newsletters

The Roles of MicroRNA in Pancreatic Cancer Progression

[Cancer Investigation] The authors review the recent developments in miRNAs and their target role in the development, metastasis, migration, and invasion in PDAC.

1...620621622 Page 621 of 622

Extracellular Vesicles Promote Migration despite BRAF Inhibitor Treatment in Malignant Melanoma Cells

[Cell Communication and Signaling] Researchers elucidated the involvement of extracellular vesicles (EV) in malignant melanoma progression and ascertained whether EV-mediated metastasis promotion persisted during single agent BRAF or MEK and combined BRAF/MEK inhibition.

Cholesterol Neutralized Vemurafenib Treatment by Promoting Melanoma Stem-Like Cells via Its Metabolite 27-Hydroxycholesterol

[Cellular and Molecular Life Sciences] Scientists found that lowering intracellular cholesterol by knocking down DHCR24, the limiting synthetase, impaired tumor cell proliferation and migration and abrogated the ability to xenotransplant tumors.

Melatonin Promotes Hair Regeneration by Modulating the Wnt/β-Catenin Signaling Pathway

[Cell Proliferation] In-depth analysis of the expression of key molecules in the Wnt/β-catenin signaling pathway revealed that melatonin up-regulated the Wnt/β-catenin signaling pathway in dermal papillae, whereas these effects were facilitated through mediating Wnt ligand expression levels in the hair follicle stem cells.

All Articles by Author:

Bob

Popular