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The Role of Feedback Loops in Targeted Therapy for Pancreatic Cancer

[Frontiers in Oncology] Scientists review researches on the role of feedback loops in the progression of pancreatic cancer, and summarize the connection between feedback loops and several signaling pathways in pancreatic cancer, as well as recent advances in the intervention of feedback loops in pancreatic cancer treatment.

BC Researchers Launching Clinical Trial for First Genetically Engineered Stem Cell-Based Therapy for Type 1 Diabetes

[University of British Columbia] Researchers from the UBC Faculty of Medicine and Vancouver Coastal Health have received $1 million from Canada’s Stem Cell Network to conduct research and a clinical trial for one of the world’s first genetically engineered cell replacement therapies for type 1 diabetes.

NexImmune, Yale, and JDRF Enter into Research Partnership for Type 1 Diabetes

[NexImmune, Inc.] NexImmune, Inc., Yale and JDRF have begun a two-year project to explore the use of NexImmune’s AIM nanoparticles in combination with an anti-CD3 mAb to tolerize, deplete or modulate diabetes antigen-specific T cells.

Merck Announces Phase III KEYNOTE-811 Trial Met Dual Primary Endpoint of Overall Survival as First-Line Treatment in Patients with HER2-Positive Advanced Gastric or Gastroesophageal...

[Merck & Co., Inc.] Merck announced that the Phase 3 KEYNOTE-811 trial evaluating KEYTRUDA®, in combination with trastuzumab and fluoropyrimidine- and platinum-containing chemotherapy met its dual primary endpoint of overall survival for the first-line treatment of patients with HER2-positive locally advanced unresectable or metastatic gastric or gastroesophageal junction adenocarcinoma.

Androgen Receptor Splice Variants Drive Castration-Resistant Prostate Cancer Metastasis by Activating Distinct Transcriptional Programs

[Journal Of Clinical Investigation] Investigators found that, under castrated conditions, androgen receptor (AR)-V7 strongly induced osteoblastic bone lesions, a response not observed with full-length AR overexpression.

Prostate Cancer Screening Methods Trialed in ‘Pivotal Moment’

[The Guardian] Methods of screening men for prostate cancer will be trialed in an attempt to save thousands of lives in the UK each year, in what has been hailed as a “pivotal moment” by experts.

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