lbeveridge

[iScience] Single-cell transcriptome analysis of hepatic CD11b+ cells, main producers of matrix metalloproteinases, revealed a prominent cluster of restorative Tlr4-expressing Ly6c2-low myeloid cells.

[Nature Cell Biology] The authors delineated a molecular pathway that links stiff ECM to activation of Akt, which in turn promoted GTP loading to Rab8 that drove' exosome secretion.

[Arrowhead Pharmaceuticals, Inc.] Arrowhead Pharmaceuticals, Inc. announced that it has gained rights to ARO-PNPLA3, formerly called JNJ-75220795, which was part of a 2018 research collaboration and option agreement between Arrowhead and Janssen Pharmaceuticals, Inc., one of the Janssen Pharmaceutical Companies of Johnson & Johnson.

[Cell Stem Cell] Scientists uncovered that periportal-specific liver progenitor-like cell formation was initiated by regionally activated Kupffer cells but not peripheral monocyte-derived macrophages.

[Nature Communications] Researchers demonstrated that scaffolds crosslinked with nano-graphene oxide show high resistance to enzymatic degradation via direct inhibition of matrix metalloproteinase activity and increased mechanical rigidity.

[Journal of Experimental Medicine] Investigators tested the susceptibility of seven mouse strains to develop non-alcoholic steatohepatitis (NASH). The severity of the clinical phenotypes observed varied widely across strains.