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Mesenchymal Cell News

Incorporation of Paclitaxel in Mesenchymal Stem Cells Using Nanoengineering Upregulates Antioxidant Response, CXCR4 Expression and Enhances Tumor Homing

[Materials Today Bio] Loading paclitaxel in MSCs resulted in increased levels of mitochondrial reactive oxygen species. In response to this oxidative stress, MSCs upregulated two important set of proteins.

Mesenchymal Cell News

Celularity Receives Preliminary Assessment of Product Classification and Jurisdiction for Its Investigational Celularity Tendon Wrap (CTW) to be Regulated as a Device Within U.S....

[Celularity, Inc.] Celularity, Inc. announced that the FDA has reviewed information provided by the Company and other relevant available information, and agreed with the Company’s recommendation that its investigational CTW product be regulated as a device by the FDA Center for Devices and Radiologic Health.

Mesenchymal Cell News

Manufacture of Extracellular Vesicles Derived from Mesenchymal Stromal Cells

[Trends In Biotechnology] New advanced methods have been developed to upscale MSC cultivation and extracellular vesicles production yields, ranging from new cell culture devices to priming procedures.

Mesenchymal Cell News

Adipokines at the Crossroads of Obesity and Mesenchymal Stem Cell Therapy

[Experimental & Molecular Medicine] The authors summarize recent advances in the use of MSC for the treatment of obesity-associated diseases to support the hypothesis that adipokines modulate the benefits of MSC therapy in obese patients.

Extracellular Matrix News

Why Does Understanding the Biology of Fibroblasts in Immunity Really Matter?

[PLOS Biology] Scientists present fibroblasts as not only the builders and renovators of tissue environments but also the rheostat cells for immune circuits.

Dermal Cell News

Obstructive Sleep Apnoea Is Related to Melanoma Aggressiveness through Paraspeckle Protein-1 Upregulation

[European Respiratory Journal] In 292 cutaneous melanoma patients, sleep studies and serum levels of PSPC1 and TGF-β were evaluated. The effect of PSPC1 on expression of EMT and cancer stem cell transcription factors was assessed using melanoma cell lines with patient sera under both normoxia and intermittent hypoxia conditions.

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Sylvester Cancer Adding Cellular Therapy to its Arsenal against Metastatic Melanoma

[University of Miami Miller School of Medicine (EurekAlert!)] Patients in South Florida with metastatic melanoma will soon have access to tumor-infiltrating lymphocyte therapy, following its recent approval by the FDA. It will be available to patients at Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine.

The Role of Yes Activated Protein (YAP) in Melanoma Metastasis

[iScience] The authors discuss how therapeutically targeting YAP through YAP inhibitors verteporfin and celastrol and its downstream mediators CCN1 and CCN2 might be useful in treating melanoma.

Exploration of the Photothermal Role of Curcumin-Loaded Targeted Carbon Nanotubes as a Potential Therapy for Melanoma Cancer

[Scientific Reports] Scientists designed and evaluated targeted carbon nanotubes containing curcumin, and assessed their in vitro cytotoxicity effects on melanoma cancer cells.

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