Obstructive Sleep Apnoea Is Related to Melanoma Aggressiveness through Paraspeckle Protein-1 Upregulation

In 292 cutaneous melanoma patients, sleep studies and serum levels of PSPC1 and TGF-β were evaluated. The effect of PSPC1 on expression of EMT and cancer stem cell transcription factors was assessed using melanoma cell lines with patient sera under both normoxia and intermittent hypoxia conditions.