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lbeveridge

An Endogenously Activated Antiviral State Restricts SARS-CoV-2 Infection in Differentiated Primary Airway Epithelial Cells

[PLoS One] Researchers showed that an endogenously activated interferon lambda pathway led to resistance against SARS-CoV-2 infection.

SARS-CoV-2 Infection Relaxes Peripheral B Cell Tolerance

[Journal of Experimental Medicine] The authors demonstrated that BND cells from SARS-CoV-2 severely infected individuals were significantly activated, displayed reduced inhibitory receptor expression, and restored B cell receptor signaling, indicative of a breach in anergy during viral infection, supported by increased levels of autoreactive antibodies.

Systems Analysis Shows a Role of Cytophilic Antibodies in Shaping Innate Tolerance to Malaria

[Cell Reports] Investigators profiled the blood immune system in patients, with or without prior malaria exposure, over 1 year after acute symptomatic Plasmodium falciparum malaria.

Long-Term, CD4+ Memory T Cell Response to SARS-CoV-2

[Frontiers in Immunology] A cohort of convalescent healthcare workers was recruited and their immune responses were studied over a period of three to nine months following the onset of symptoms.

Bladder Epithelial Cell Phosphate Transporter Inhibition Protects Mice against Uropathogenic Escherichia coli Infection

[Cell Reports] Researchers showed that Escherichia coli sensed host immune responses and initiated escape by upregulating a key phospholipase.

ILC Precursors Differentiate into Metabolically Distinct ILC1-Like Cells during Mycobacterium tuberculosis Infection

[Cell Reports] Scientists showed that Mycobacterium tuberculosis infection alters the phenotype and function of lung IL-18Rα+ innate lymphoid cells (ILCs) toward a protective interferon-γ-producing ILC1-like population.

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Single-Cell Analysis of Anti-BCMA CAR T Cell Therapy in Patients with Central Nervous System Autoimmunity

[Science Immunology] Investigators performed single-cell multi-omics sequencing of paired cerebrospinal fluid and blood samples from patients with neuromyelitis optica spectrum disorder treated with anti–B cell maturation antigen (BCMA) CAR T cells.

Unveiling the Proteome-Wide Autoreactome Enables Enhanced Evaluation of Emerging CAR-T Therapies in Autoimmunity

[European Journal Of Clinical Investigation] Researchers leveraged advances in programmable-phage immunoprecipitation methodology to explore the modulation, or lack thereof, of autoantibody profiles, proteome-wide, in both health and disease.

Arming Vδ2 T Cells With Chimeric Antigen Receptors to Combat Cancer

[Clinical Cancer Research] Following a comprehensive overview of γδ T cell biology and innovative CAR engineering strategies, investigators discuss the clinical potential of Vδ2 CAR-T cells to overcome the current limitations of immunotherapy in solid tumors.