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lbeveridge

TRIM31 Confers Protection against Nonalcoholic Steatohepatitis by Deactivating MAP3K7

[Hepatology] Scientists identified the RING-type E3 ubiquitin transferase-tripartite motif-containing protein 31, a member of E3 ubiquitin ligases family, as a novel and efficient endogenous inhibitor of transforming growth factor-beta-activated kinase 1.

Magnetic Hydrogel for Cartilage Tissue Regeneration as Well as a Review on Advantages and Disadvantages of Different Cartilage Repair Strategies

[Biomed Research International] The authors illustrated various hydrogels used for cartilage regeneration by highlighting the magnetic hydrogels.

lncRNA KCNQ1OT1 Promotes EMT, Angiogenesis, and Stemness of Pituitary Adenoma by Upregulation of RAB11A

[Journal of Oncology] Scientists investigated the effect and mechanism of long noncoding RNA KCNQ1OT1 on pituitary adenoma. The KCNQ1OT1 expression in invasive and noninvasive PA tissues was detected by real-time fluorescence quantitative polymerase chain reaction.

Vascular Derived Endothelin Receptor a Controls Endothelin-Induced Retinal Ganglion Cell Death

[Cell Death Discovery] Scientists deleted Edn receptors from specific cell types to identify the critical endothelin receptor mediating retinal ganglion cell death in vivo.

Near Infra-Red Labelling and Tracking of Corneal Endothelial Cells In-Vivo

[Scientific Reports] Scientists developed a labeling approach using 1,1′-dioctadecyl-3,3,3′,3′-tetramethylindotricarbocyanine iodide dye solution, that enables tracking of labelled corneal endothelial cells in vivo for at least one month.

Intracellular pH Affects Mitochondrial Homeostasis in Cultured Human Corneal Endothelial Cells Prepared for Cell Injection Therapy

[Scientific Reports] Analysis of polarized expression of ion transporters on cultured human corneal endothelial cells subpopulations was performed.

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Targeting EMT Using Low-Dose Teniposide by Downregulating ZEB2-Driven Activation of RNA Polymerase I in Breast Cancer

[Cell Death & Disease] Researchers demonstrated Teniposide as a potent modulator of the epithelial–mesenchymal transition (EMT) program, specifically through an interferon regulatory factor 7 (IRF7)–N-myc and STAT interactor (NMI) mediated response.

A Prismatic View of the Epigenetic-Metabolic Regulatory Axis in Breast Cancer Therapy Resistance

[Oncogene] The authors discuss interconnected epigenetic and metabolic regulatory pathways and then integrate them into an observable cancer metabolism-therapy-resistance axis that may inform clinical intervention.

SUCNR1 Regulates Insulin Secretion and Glucose Elevates the Succinate Response in People with Prediabetes

[Journal Of Clinical Investigation] Scientists reported that the succinate receptor (SUCNR1) was expressed in β-cells and was up-regulated in hyperglycemic states in mice and humans.