lbeveridge

[ACS Biomaterials Science & Engineering] Investigators found that a portion of H2O2-treated vascular smooth muscle cells (VSMCs) underwent senescence, and that conditioned medium of HH2O2-treated senescent VSMCs triggered the proliferation of quiescent VSMCs.

[Journal of Molecular and Cellular Cardiology] Scientists compared and optimized protocols for the isolation of cardiomyocytes (CMs) from embryonic to adult stages. They found that the trypsin digestion method was suitable for embryonic mouse CM isolation.

[Journal of Cardiovascular Translational Research] The authors found that chaetocin suppressed the migration of vascular smooth muscle cells (VSMC). Moreover, chaetocin treatment induced a contractile phenotype in VSMCs by increasing α-SMA and SM22α expression.

[Cell Communication and Signaling] The authors examined the effects of endoplasmic reticulum (ER) stress on PGC-1α levels in muscle and the potential mechanisms involved. The human skeletal muscle cell line LHCN-M2 and mice exposed to different inducers of ER stress were used.

[Toxicology in Vitro] Researchers found that Benzo[a]pyrene exposure led to the inhibition of C2C12 myoblasts differentiation in a dose-dependent manner and reduced the expression of both early and late myogenic differentiation markers.

[Science Advances] Scientist systematically studied the impact of matrix stiffness and (hemodynamic) pressure on vascular smooth muscle cells (VSMCs). They found that pressure and stiffness individually affected the VSMC phenotype.