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KMT2C Deficiency Promotes Small Cell Lung Cancer Metastasis through DNMT3A-Mediated Epigenetic Reprogramming

[Nature Cancer] To understand the molecular mechanisms underlying SCLC metastasis, the authors generated SCLC mouse models with orthotopically transplanted genome-edited lung organoids and performed multiomics analyses.

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Therapeutic Efficacy of the Novel SHP2 Degrader SHP2-D26, Alone or in Combination, against Lung Cancer Is Associated with Modulation of p70S6K/S6, Bim and Mcl-1

[Cancer Gene Therapy] Researchers evaluated the therapeutic potential of the novel SHP2 degrader, SHP2-D26, either alone or in combination, against NSCLC cells.

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Downregulation of CircATXN7 Represses Non-Small Cell Lung Cancer Growth by Releasing miR-7-5p

[Thoracic Cancer] CircRNA ataxin 7 (circATXN7) accelerated the malignancy of NSCLC cells through adsorbing miR-7-5p and upregulating profilin 2.

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Neonatal Lung-Derived SSEA-1+ Cells Exhibited Distinct Stem/Progenitor Characteristics and Organoid Developmental Potential

[iScience] The authors showed that neonatal-derived pulmonary SSEA-1+ cells highly expressed lung development-associated genes and had enhanced organoid generation ability compared with the adult cells.

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Accuracy of Portable Spirometers in the Diagnosis of Chronic Obstructive Pulmonary Disease a Meta-Analysis

[NPJ Primary Care Respiratory Medicine] The authors systematically evaluate the diagnostic value of portable spirometers in detecting COPD.

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Sintilimab for the Treatment of Non-Small Cell Lung Cancer

[Biomarker Research] Scientists provide an overview of sintilimab-based clinical trials on NSCLC, and support further investigation of sintilimab in future clinical trials.

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Dysregulation of Pancreatic β-Cell Autophagy and the Risk of Type 2 Diabetes

[Autophagy] Autophagy regulates pancreatic β cell functions by different mechanisms, although the precise role of autophagy in type 2 diabetes (T2D) is not completely understood. Scientists discuss the protective and harmful roles of autophagy in the pancreatic β-cell and in the pathophysiology of T2D.

A PDE3A-SLFN12 Molecular Glue Exhibits Significant Antitumor Activity in TKI-Resistant Gastrointestinal Stromal Tumors

[Clinical Cancer Research] Investigators tested the efficacy of a novel non-tyrosine kinase inhibitors compound, OPB-171775, using patient-derived xenograft models of gastrointestinal stromal tumor.

AMBRA1 Levels Predict Resistance to MAPK Inhibitors in Melanoma

[Proceedings of The National Academy of Sciences of The United States of America] Investigators showed that the clinical development of resistance to mitogen-activated protein kinase inhibitors (MAPKi) was associated with reduced tumor expression of the melanoma suppressor autophagy and beclin 1 regulator 1 (AMBRA1) and that lower expression levels of AMBRA1 predicted a poor response to MAPKi treatment.

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