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Noshin Noorjahan

Stromal Androgen Signaling Acts as Tumor Niches to Drive Prostatic Basal Epithelial Progenitor-Initiated Oncogenesis

[Nature Communications] Scientists demonstrated that loss of androgen receptor in stromal sonic-hedgehog Gli1-lineage cells diminished prostate epithelial oncogenesis and tumor development using in vivo assays and mouse models.

Prostate-Specific Membrane Antigen Targeted Deep Tumor Penetration of Polymer Nanocarriers

[ACS Applied Materials & Interfaces] To evaluate the performance of nanocarriers in improving imaging contrast and therapeutic efficacy, researchers designed and synthesized prostate cancer-targeting starPEG nanocarriers with one or three prostate-specific membrane antigen-targeting urea-based ACUPA ligands.

Integrative Molecular Analyses Define Correlates of High B7-H3 Expression in Metastatic Castrate-Resistant Prostate Cancer

[npj Precision Oncology] Investigators interrogated B7-H3 expression and its regulation in metastatic castration-resistant prostate cancer since B7-H3 could be an excellent therapy target due to its overexpression in prostate cancer with minimal expression in normal tissues and association with poor prognosis.

Prostate Cancer-Associated Urinary Proteomes Differ before and after Prostatectomy

[Therapeutic Advances in Medical Oncology] Scientists focused on urinary proteomes of patients with prostate cancer and identified tumor-modifying proteins in the samples before and after prostatectomy.

Post-Prostatic-Massage Urine Exosomes of Men with Chronic Prostatitis/Chronic Pelvic Pain Syndrome Carry Prostate-Cancer-Typical microRNAs and Activate Proto-Oncogenes

[Molecular Oncology] Researchers investigated microRNAs in exosomes isolated from blood and post-prostatic-massage urine of chronic prostatitis/chronic pelvic pain syndrome type IIIb patients and healthy men.

HSPB8 Facilitates Prostate Cancer Progression via Activating JAK/STAT3 Signaling Pathway

[Biochemistry and Cell Biology] Investigators determined heat shock protein B8 (HSPB8) expression in prostate cancer (PC) tissues by immunohistochemical staining and explored the in vitro functions of HSPB8 using HSPB8 knockdown DU145 and LNcap PC cell lines.

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Tyrosine Phosphorylation of CARM1 Promotes Its Enzymatic Activity and Alters Its Target Specificity

[Nature Communications] The authors showed that the hyperactivation of Janus kinase 2 by the V617F mutation phosphorylated tyrosine residues in coactivator-associated arginine methyltransferase 1 (CARM1), an important target in hematologic malignancies, increasing its methyltransferase activity and altering its target specificity.

Clinical Associations with a Polygenic Predisposition to Benign Lower White Blood Cell Counts

[Nature Communications] Researchers investigated the clinical consequences of a genetic predisposition toward lower white blood cell (WBC) counts among 89,559 biobank participants from tertiary care centers using a polygenic score for WBC count comprising single nucleotide polymorphisms not associated with disease.

SUCLG1 Restricts POLRMT Succinylation to Enhance Mitochondrial Biogenesis and Leukemia Progression

[EMBO Journal] Investigators reported that expression of tricarboxylic acid cycle enzyme succinate-CoA ligase SUCLG1 strongly correlated with electron transport chain genes across various TCGA cancer transcriptomes.