Noshin Noorjahan

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Zymosan-A Promotes the Regeneration of Intestinal Stem Cells by Upregulating ASCL2

[Cell Death & Disease] Through organoid experiments, scientists found that Zymosan-A promoted the proliferation and differentiation of intestinal stem cells after ionizing radiation.

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Patient-Derived Parathyroid Organoids as a Tracer and Drug-Screening Application Model

[Stem Cell Reports] Researchers aimed to establish a patient-derived parathyroid organoid model representing human parathyroid tissue. Hyperplastic parathyroid tissue was dispersed, and parathyroid organoids were cultured and characterized.

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Self-Organizing In Vitro Mouse Neural Tube Organoids Mimic Embryonic Development

[Development] Scientists reported a self-organizing 3D neural tube organoid model derived from single mESCs that exhibited an in vivo-like tissue architecture, cell type composition, and anterior-posterior patterning.

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Development and Characterization of Patient-Derived Salivary Gland Cancer Organoid Cultures

[Oral Oncology] Successful patient-derived organoids were phenotypically characterized byimmunohistochemistry and genotypically by gene fusion analysis, and by targeted and whole-exome sequencing.

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MiraCosta College Wins Grant to Support Stem Cell Research

[MiraCosta College] MiraCosta College has received a state grant of almost $2.9 million that will be used to offer internships, mentoring, and financial support to encourage students to pursue careers in stem cell research and manufacturing.

ESC & iPSC News

bESC from Cloned Embryos Do Not Retain Transcriptomic or Epigenetic Memory from Somatic Donor Cells

[Reproduction] Investigators applied cutting-edge technologies to analyze the transcriptomic and epigenomic landscape of bovine ESC obtained from in vitro fertilized and somatic cell nuclear transfer embryos.

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Sylvester Cancer Adding Cellular Therapy to its Arsenal against Metastatic Melanoma

[University of Miami Miller School of Medicine (EurekAlert!)] Patients in South Florida with metastatic melanoma will soon have access to tumor-infiltrating lymphocyte therapy, following its recent approval by the FDA. It will be available to patients at Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine.

The Role of Yes Activated Protein (YAP) in Melanoma Metastasis

[iScience] The authors discuss how therapeutically targeting YAP through YAP inhibitors verteporfin and celastrol and its downstream mediators CCN1 and CCN2 might be useful in treating melanoma.

Exploration of the Photothermal Role of Curcumin-Loaded Targeted Carbon Nanotubes as a Potential Therapy for Melanoma Cancer

[Scientific Reports] Scientists designed and evaluated targeted carbon nanotubes containing curcumin, and assessed their in vitro cytotoxicity effects on melanoma cancer cells.

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Noshin Noorjahan

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