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Cancer Stem Cell News is an online resource that curates the top research publications and reviews about cancer progenitor cells and cancer stem cells.
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Extracellular Matrix Mediates Circulating Tumor Cell Clustering in Triple-Negative Breast Cancer Metastasis
[Nature Communications] Researchers showed that the ECM component hyaluronan mediates adherens junction-independent circulating tumor cell clustering in triple-negative breast cancers.
Ebastine Targets HER2/HER3 Signaling and Cancer Stem Cell Traits to Overcome Trastuzumab Resistance in HER2‑Positive Breast Cancer
[International Journal of Molecular Medicine] Scientists evaluated the therapeutic potential of ebastine as a repurposing candidate to overcome trastuzumab resistance by targeting HER2 signaling and CSC‑associated phenotypes in HER2‑positive breast cancer cells.
OSBPL2-Mediated Lipid Metabolism Alteration Governs Lung Cancer Stem Cells Properties
[Stem Cell Research & Therapy] Investigators observed that oxysterol-binding protein-like 2 (OSBPL2) reduced cholesterol content by HPLC-MS. It inhibited the accumulation of lipid droplets in lung cancer.
SHH Pathway Inhibition and Astrocyte Co-Culture Induce Distinct Responses in Glioblastoma and Cancer Stem Cells
[Scientific Reports] The authors investigated how SHH pathway inhibition affects both bulk glioblastoma (GBM) cells and CD133+ GBM cells, with particular emphasis on the influence of astrocyte co-culture, which more closely mimics the brain tumor microenvironment.
Alpha-Fetoprotein Acts As a Key Regulator of Cancer Stemness in Hepatocellular Carcinoma via PI3K/Akt Pathway
[Cellular Signalling] Investigators employed CRISPR/Cas9-mediated gene editing to generate alpha-fetoprotein (AFP)-knockout models in Huh7 and PLC/PRF/5 cell lines, enabling a systematic investigation of AFP's oncogenic functions.
Human Type-1 Innate Lymphoid Cells Control Leukemia Stem Cell Differentiation and Limit Acute Myeloid Leukemia Development
[Nature Communications] Researchers found that innate lymphoid cells (ILCs) in AML patients are impaired, with reduced total ILC1 numbers and diminished function.
The Oncogenic Role of Serum Marker GDF15 in Promoting Colorectal Tumorigenesis via EMT and Stemness
[Stem Cells International] GDF15 expression in colorectal cancer was analyzed using public databases and validated in patient tissues by Western blot.
Thyroid Hormone Inactivation Sustains Cancer Stem Cell Maintenance and Tumorigenesis in Basal Cell Carcinoma
[Journal of Investigative Dermatology] By integrating in vivo animal studies in a genetic mouse model of basal cell carcinoma (BCC) with analyses of human BCC specimens, the authors demonstrated that the deiodinase type 3 is expressed in the most tumorigenic CSC subpopulation.
CircKIAA1617 Promotes Stemness via USP14/PGRMC1-Mediated Autophagy and Lipid Metabolism Reprogramming in ER-Positive Breast Cancer
[Molecular Cancer] CircKIAA1617 was identified through high-throughput RNA sequencing in ER-positive breast cancer (BC) . Gain- and loss-of-function assays were performed to evaluate the functions of circKIAA1617 in ER-positive BC cells.
HNRNPF Increases MAF and CCNB2 Levels To Promote Cancer Cell Stemness and Progression of Pancreatic Ductal Adenocarcinoma
[Stem Cell Reviews and Reports] The authors investigated the impact of heterogeneous nuclear ribonucleoprotein F (HNRNPF) on tumor stemness by regulating musculoaponeurotic fibrosarcoma (MAF) stability and cyclin B2 (CCNB2) transcription in pancreatic ductal adenocarcinoma.
Targeting Wnt3a and Loxl2 Synergistically Induces Ferroptosis in Liver Cancer Stem Cells and Suppresses Tumorigenesis
[Cancer Science] The authors investigated how Wnt3a and/or Loxl2 knockdown affects liver CSCs and orthotopic tumor growth in mice, and explores the role of ferroptosis-related genes.
SNORA49 Negatively Regulates Self-Renewal of Liver Cancer Stem Cells and Hepatocarcinogenesis via Suppressing SOX9 Transcription
[Nature Communications] Scientists identified a conserved small nucleolar RNA, SNORA49, which is lowly expressed in liver CSCs, as a negative regulator of CSC self-renewal.
Cancer Stem Cell News consolidates the most recent publications covering research areas such as the identification and isolation of cancer stem cells, their proliferation and differentiation characteristics, gene expression and regulatory pathways, and the development of anti-cancer therapies. We also include cancer stem cell jobs and events hosted by leading research organizations, societies, and institutes.
