Cancer Stem Cell News

Cancer Stem Cell News is an online resource that curates the top research publications and reviews about cancer progenitor cells and cancer stem cells.

BRG1/BRM Inhibitor Targets AML Stem Cells and Exerts Superior Preclinical Efficacy Combined with BET or Menin Inhibitor

[Blood] Investigators showed that FHD-286 induced differentiation and lethality in AML cells with MLL1 rearrangement or mutant NPM1, concomitantly causing perturbed chromatin accessibility and repression of c-Myc, PU.1, and CDK4/6.

PRMT5-Mediated Methylation of STAT3 Is Required for Lung Cancer Stem Cell Maintenance and Tumor Growth

[Communications Biology] Investigators showed that PRMT5 directly methylated STAT3 and enhances its activated tyrosine phosphorylation in non-small cell lung cancer cells.

Isolation and Characterization of a Novel Mammary Adenocarcinoma, MCa-P1362, with Hormone Receptor Expression, Human Epidermal Growth Factor Receptor 2 Positivity, and Enrichment in Cancer...

[The American Journal Of Pathology] Detailed cellular and molecular characterization was conducted on MCa-P1362, a newly established mouse model of metastatic breast cancer that is syngeneic in BALB/c mice.

Recommendations for Reporting Tissue and Circulating Tumor (ct)DNA Next-Generation Sequencing Results in Non-Small Cell Lung Cancer

[British Journal Of Cancer] Scientists discuss next-generation sequencing workflows, the structure of next-generation sequencing reports, and our recommendations for best practice thereof.

GPC3-Targeted CAR-T Cells Expressing GLUT1 or AGK Exhibit Enhanced Antitumor Activity against Hepatocellular Carcinoma

[Acta Pharmacologica Sinica] The authors generated GPC3-targeted CAR-T cells overexpressing GLUT1 or AGK for the treatment of HCC. GPC3-targeted CAR-T cells overexpressing GLUT1 or AGK specifically and effectively lysed GPC3-positive tumor cells in vitro in an antigen-dependent manner.

SMYD2 Induced PGC1α Methylation Promotes Stemness Maintenance of Glioblastoma Stem Cells

[Neuro-Oncology] SMYD2-induced PGC1α methylation and followed nuclear export was confirmed by co-immunoprecipitation, cellular fractionation, and immunofluorescence.

Targeting NKG2D Ligands in Glioblastoma with a Bispecific T-Cell Engager Is Augmented with Conventional Therapy and Enhances Oncolytic Virotherapy of Glioma Stem-Like Cells

[Journal For Immunotherapy Of Cancer] Researchers designed a bispecific T cell engager capable of cross-linking CD3 on T cells with NKG2DL-expressing GBM cells. They then engineered the G207 virus to express the NKG2D BiTE and secrete it from infected cells.

Intensity Therapeutics, Inc. and The Swiss Group for Clinical Cancer Research SAKK Sign a Collaboration Agreement to Conduct a Phase II Randomized, Clinical Trial...

[Intensity Therapeutics, Inc.] Intensity Therapeutics, Inc. announced that the company executed a collaboration agreement with The Swiss Group for Clinical Cancer Research SAKK to conduct a Phase II randomized, controlled trial evaluating clinical and biological effects of intratumoral INT230-6 followed by the standard of care (SOC) immuno/chemotherapy vs. SOC immune/chemotherapy alone in early-stage triple-negative breast cancer in 54 patients in Switzerland.

Nucleoporin 93 Regulates Cancer Cell Growth and Stemness in Bladder Cancer via Wnt/β-Catenin Signaling

[Molecular Biotechnology] BLCA cells were used to investigate the effects of Nup93 overexpression or knockdown on cell growth, invasion, stemness , and Wnt/β-catenin signaling in vitro.

CD271 mRNA/hnRNPA2B1 Complex Promotes Proliferation and Stemness in Oral and Head and Neck Squamous Cell Carcinoma

[Cancer Science] The authors show edthat CD271 mRNA, but not CD271 protein, facilitates spheroid cell proliferation. They established CD271−/− cells lacking both mRNA and protein of CD271, as well as CD271 protein knockout cells lacking only CD271 protein, from hypopharyngeal and oral squamous cell carcinoma lines.

Stem Cells Derived Exosomes as Biological Nano Carriers for VCR Sulfate for Treating Breast Cancer Stem Cells

[Scientific Reports] Investigators isolated exosomes (Exos) from MSCs, and using probe-sonication approach loaded them with vincristine (VCR) sulfate. Using SRB assay, the cytotoxicity of VCR sulfate-Exo was assessed in T47D breast cancer cells, and the results were contrasted with those of free VCR sulfate.

Iron Metabolism: Backfire of Cancer Cell Stemness and Therapeutic Modalities

[Cancer Cell International] Investigators explored recent advances in iron metabolism in CSCs, conventional cancer therapies targeting iron biochemistry, therapeutic resistance in these cells, and potential treatment options that could overcome them.

Cancer Stem Cell News consolidates the most recent publications covering research areas such as the identification and isolation of cancer stem cells, their proliferation and differentiation characteristics, gene expression and regulatory pathways, and the development of anti-cancer therapies. We also include cancer stem cell jobs and events hosted by leading research organizations, societies, and institutes.