Tumor Endothelial Cell-Derived Sfrp1 Supports the Maintenance of Cancer Stem Cells via Wnt Signaling

Investigators elucidated angiocrine factors related to CSC maintenance, focusing on Secreted frizzled-related protein 1 (Sfrp1). Although Sfrp1 is a Wnt pathway-related factor, its impact on tumor tissues remains unknown.