Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
Cancer Stem Cell News
Cancer Stem Cell News is an online resource that curates the top research publications and reviews about cancer progenitor cells and cancer stem cells.
SMYD3 Activates Fatty Acid β-Oxidation to Promote Self-Renewal of Leukemia Stem Cells
Researchers validated the critical role of the histone methyltransferase SET and MYND domain-containing 3 (SMYD3) in the maintenance of leukea stem cells in chronic...
CDX1 and CDX2 Suppress Colon Cancer Stemness by Inhibiting β-Catenin-Facilitated Formation of Pol II-DSIF-PAF1C Complex
[Cell Death & Disease] Investigators showed that complete loss of Cdx1 or concurrent loss of Cdx1/2 increased the stemness and malignancy of intestinal tumors.
DAZAP1 Maintains Gastric Cancer Stemness by Inducing Mitophagy
[JCI Insight] Scientists investigated DAZ-associated protein 1's (DAZAP1’s) impact on gastric cancer stemness and its mechanisms. DAZAP1 promoted tumor progression in gastric cancer stem cells, as shown by sphere formation assays and stemness marker analysis.
The Cancer-Associated Fibroblast Facilitates YAP Liquid-Liquid Phase Separation to Promote Cancer Cell Stemness in HCC
[Cell Communication and Signaling] Investigators identified a novel long non-coding RNA NEAT1 in cancer-associated fibroblast-derived extracellular vesicles that play a critical role in the induction of CSCs and hepatocellular carcinoma tumorigenesis.
Sohlh1 Modulates the Stemness and Differentiation of Glioma Stem-Like Cells by Inactivation of Wnt/β-Catenin Signaling Pathway via SFRP1
[Journal of Cellular and Molecular Medicine] Scientists demonstrated that Sohlh1 functioned through the SFRP1/Wnt/β-catenin signalling pathway and led to the consequent suppression of glioma stem-like cells (GSLC) stemness and the promotion of GSLC differentiation in vitro and in vivo.
Targeting of the IL-33/Wnt Axis Restricts Breast Cancer Stemness and Metastasis
[Scientific Reports] Scientists investigated the Interleukin-33 (IL-33)/ST2 axis in breast cancer using CRISPR/Cas9, single-cell RNA sequencing, and murine models. IL-33 overexpression enhanced proliferation, migration, and CSC marker expression in 4T1 and MDA-MB-231 cells, whereas ST2 knockdown via CRISPR or adeno-associated virus attenuated tumor growth and metastasis in vivo, reducing CSC frequency.
Cinobufagin Inhibits Hepatocellular Carcinoma EMT-Like Stemness via VEGF/VEGFR2 Autocrine Signaling
[Discover Oncology] Researchers explored the role of the VEGFa/VEGFR2 autocrine pathway in cinobufagin-induced inhibition of hepatocellular carcinoma metastasis.
Combined Analysis of Somatic Mutations and Gene Expression Reveals Nuclear Speckles-Associated Enhanced Stemness in Gingivobuccal Carcinoma under DNA Damage Response
[Computational Biology and Chemistry] An RNA-sequencing data-based combined analysis of somatic mutations and gene expression was performed to explore the role of CSCs in disease progression using the novel Indian-origin Gingivobuccal oral squamous cell carcinoma cell line ‘IIOC019’ from a patient with tobacco-chewing habit.
Exosomes in Bridging Macrophage-Fibroblast Polarity and Cancer Stemness
[Medical Oncology] CSC-derived exosomal transforming growth factor-β is a key driver of cancer-associated fibroblasts and type 2 macrophage polarization, with the latter mediated through activation of signal transducer and activator of transcription 3.
Avenzo Therapeutics Initiates Phase I/II Clinical Study of AVZO-1418, a Potential Best-in-Class, Novel EGFR/HER3 Bispecific Antibody-Drug Conjugate
[Avenzo Therapeutics, Inc.] Avenzo Therapeutics, Inc.announced initiation of a Phase I/II clinical study of its potential best-in-class EGFR/HER3 bispecific antibody-drug conjugate, AVZO-1418, in patients with advanced solid tumors.
Mn-Coordination Driven Glutamine and Cancer Stemness Dual-Tailored Nano-Herb for High-Efficiency Activation of Dendritic Cells
[Biomaterials] Scientists developed a manganese-coordination driven glutamine and cancer stemness dual-tailored nano-herb for high-efficiency activation of dendritic cells.
Nanomaterials for Delivery of Drugs and Genes to Disrupt Notch Signaling Pathway in Breast Cancer
[Naunyn-Schmiedebergs Archives of Pharmacology] The authors examine recent breakthroughs in nanocarrier systems aimed at the Notch signaling pathway in breast cancer, highlighting the therapeutic potential of integrating nanomedicine with Notch inhibition to disrupt epithelial-mesenchymal transition, tumor-initiating cells, and metastasis, thereby enhancing clinical outcomes.
Cancer Stem Cell News consolidates the most recent publications covering research areas such as the identification and isolation of cancer stem cells, their proliferation and differentiation characteristics, gene expression and regulatory pathways, and the development of anti-cancer therapies. We also include cancer stem cell jobs and events hosted by leading research organizations, societies, and institutes.
