LC3B Upregulation by NANOG Promotes Immune Resistance and Stem-Like Property through Hyperactivation of EGFR Signaling in Immune-Refractory Tumor Cells

Scientists report that the emergence of refractory phenotypes was highly associated with an aberrant macroautophagic/autophagic state of NANOG+ tumor cells and that the autophagic phenotype arises through transcriptional induction of MAP1LC3B/LC3B by NANOG.
[Autophagy]
Kim, S., Cho, H., Hong, S.-O., Oh, S. J., Lee, H.-J., Cho, E., Woo, S. R., Song, J. S., Chung, J.-Y., Son, S. W., Yoon, S. M., Jeon, Y.-M., Jeon, S., Yee, C., Lee, K.-M., Hewitt, S. M., Kim, J.-H., Song, K.-H., & Kim, T. W. (2020). LC3B upregulation by NANOG promotes immune resistance and stem-like property through hyperactivation of EGFR signaling in immune-refractory tumor cells. Autophagy, 0(ja), null. https://doi.org/10.1080/15548627.2020.1805214 Cite
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Apigenin Enhanced Antitumor Effect of Cisplatin in Lung Cancer via Inhibition of Cancer Stem Cells

Scientists attempted to clarify whether apigenin could improve the antitumor efficiency of cisplatin in lung cancer using cancer stem cells.
[Nutrition and Cancer-An International Journal]
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Antagonists of the Serotonin Receptor 5A Target Human Breast Tumor Initiating Cells

Researchers found that selective antagonists of 5-HT5A reduced the frequency of tumorsphere initiating cells residing in breast tumor cell lines and those of patient-derived xenografts that they established.
[BMC Cancer]
Gwynne, W. D., Shakeel, M. S., Girgis-Gabardo, A., Kim, K. H., Ford, E., Dvorkin-Gheva, A., Aarts, C., Isaac, M., Al-awar, R., & Hassell, J. A. (2020). Antagonists of the serotonin receptor 5A target human breast tumor initiating cells. BMC Cancer, 20(1), 724. https://doi.org/10.1186/s12885-020-07193-6 Cite
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The Role of Mitochondrial Proteases in Leukemic Cells and Leukemic Stem Cells

Investigators highlight the functional consequences of inhibiting and activating mitochondrial proteases and discuss their potential as therapeutic targets in acute myeloid leukemia.
[Stem Cells Translational Medicine]
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Development of an Artificial Antibody Specific for HLA/Peptide Complex Derived from Cancer Stem-Like Cell/Cancer-Initiating Cell Antigen DNAJB8

Investigators developed a therapeutic single-chain variable-fragment antibody that recognises the cancer stem-like cell/cancer-initiating cell antigen, DNAJB8.
[British Journal of Cancer]
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Polydatin Executes Anticancer Effects against Glioblastoma Multiforme by Inhibiting the EGFR-AKT/ERK1/2/STAT3-SOX2/Snail Signaling Pathway

The authors demonstrated that polydatin repressed cell proliferation, migration, invasion and stemness and promoted apoptosis in glioblastoma multiforme cells.
[Life Sciences]
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Interplay between V-ATPase G1 and Small EV-miRNAs Modulates ERK1/2 Activation in GBM Stem Cells and Non-Neoplastic Milieu

The authors investigated the role of V1G1 in glioma stem cell small extracellular vesicles and their effects on primary brain cultures.
[Molecular Cancer Research]
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Effects of Cancer Stem Cells in Triple-Negative Breast Cancer and Brain Metastasis: Challenges and Solutions

The authors summarize recent literature regarding molecules and pathways and reviewed the effects of cancer stem cell biology during the formation of brain metastasis in triple-negative breast cancer.
[Cancers]
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Cytovia Therapeutics Acquires Worldwide Rights to CytoImmune Therapeutics’ First-In-Class EGFR Dual-Targeting CAR for NK Cell Treatment of Glioblastoma & Other Solid Tumors

Cytovia Therapeutics, Inc announced that it has acquired worldwide rights from CytoImmune Therapeutics for its novel EGFR dual-targeting CAR to be used for NK cell therapy.
[Cytovia Therapeutics, Inc. (GlobeNewswire, Inc.)]
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AUF1 Promotes Stemness in Human Mammary Epithelial Cells through Stabilization of the EMT Transcription Factors TWIST1 and SNAIL1

Researchers showed that AUF1 induced epithelial-to-mesenchymal transition and stemness in breast epithelial cells via stabilization of the SNAIL1 and TWIST1 mRNAs, and their consequent upregulation.
[Oncogenesis]
AlAhmari, M. M., Al-Khalaf, H. H., Al-Mohanna, F. H., Ghebeh, H., & Aboussekhra, A. (2020). AUF1 promotes stemness in human mammary epithelial cells through stabilization of the EMT transcription factors TWIST1 and SNAIL1. Oncogenesis, 9(8), 1–12. https://doi.org/10.1038/s41389-020-00255-1 Cite
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Twitter Account of Embattled #MeTooSTEM Founder Suspended

Twitter has suspended the account of MeTooSTEM founder BethAnn McLaughlin after allegations emerged that the former Vanderbilt University neuroscientist fabricated the Twitter account of an apparently nonexistent female Native American anthropologist at Arizona State University who had claimed to be an anonymous victim of sexual harassment by a Harvard professor.
[ScienceInsider]
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DOCK6 Promotes Chemo- and Radioresistance of Gastric Cancer by Modulating WNT/β-Catenin Signaling and Cancer Stem Cell Traits

The authors identified DOCK6, a guanine nucleotide exchange factor for Rac1 and CDC42, as an independent biomarker for gastric cancer prognosis. Clinical findings indicate the positive correlation of higher DOCK6 expression with tumor size, depth of invasion, lymph node metastasis, vascular invasion, and pathological stage.
[Oncogene]
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