Using conditional knockout and reporter mouse models, the authors demonstrated that tumor cells expressing the Notch ligand Dll1 was important for tumor growth and metastasis and bear similarities to tumor-initiating cancer cells in breast cancer.
[Nature Communications]
Kumar, S., Nandi, A., Singh, S., Regulapati, R., Li, N., Tobias, J. W., Siebel, C. W., Blanco, M. A., Klein-Szanto, A. J., Lengner, C., Welm, A. L., Kang, Y., & Chakrabarti, R. (2021). Dll1 + quiescent tumor stem cells drive chemoresistance in breast cancer through NF-κB survival pathway. Nature Communications, 12(1), 432. https://doi.org/10.1038/s41467-020-20664-5 Cite
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