Scientists report that the emergence of refractory phenotypes was highly associated with an aberrant macroautophagic/autophagic state of NANOG+ tumor cells and that the autophagic phenotype arises through transcriptional induction of MAP1LC3B/LC3B by NANOG.
[Autophagy]
Kim, S., Cho, H., Hong, S.-O., Oh, S. J., Lee, H.-J., Cho, E., Woo, S. R., Song, J. S., Chung, J.-Y., Son, S. W., Yoon, S. M., Jeon, Y.-M., Jeon, S., Yee, C., Lee, K.-M., Hewitt, S. M., Kim, J.-H., Song, K.-H., & Kim, T. W. (2020). LC3B upregulation by NANOG promotes immune resistance and stem-like property through hyperactivation of EGFR signaling in immune-refractory tumor cells. Autophagy, 0(ja), null. https://doi.org/10.1080/15548627.2020.1805214 Cite
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