Scientists demonstrated that the downregulation of caveolin-1 usually occurred in breast cancer stem cells and was associated with a metabolic switch from mitochondrial respiration to aerobic glycolysis.
[Cell Death & Disease]
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Category Archives: Cancer Stem Cell
Cancer Stem Cell NewsCancer Stem Cell News is an online publication and email newsletter that curates the top research publications and reviews about cancer progenitor cells and cancer stem cells.
Cancer Stem Cell News consolidates the most recent publications covering research areas such as the identification and isolation of cancer stem cells, their proliferation and differentiation characteristics, gene expression and regulatory pathways, and the development of anti-cancer therapies. We also include cancer stem cell jobs and events hosted by leading research organizations, societies, and institutes.
Caveolin-1 Inhibits Breast Cancer Stem Cells via c-Myc-Mediated Metabolic Reprogramming
A Positive Feedback Loop between c-Myc Up-Regulation, Glycolytic Shift and Histone Acetylation Enhances Cancer Stem Cell-Like Property and Tumorigenicity of Cr(VI)-Transformed Cells
Researchers investigated the potential role and mechanism of metabolism dysregulation in chronic hexavalent chromium [Cr(VI)] carcinogenesis. It was found that Cr(VI)-transformed cells displayed glycolytic shift, which depends on the up-regulation of c-Myc.
[Toxicological Sciences]
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Ibuprofen Mediates Histone Modification to Diminish Cancer Cell Stemness Properties via a COX2-Dependent Manner
The authors report that ibuprofen diminished cancer cell stemness properties that include reducing the ALDH+ subpopulation, side population and sphere formation in three cancer types.
[British Journal of Cancer]
Shen, W., Zhang, X., Du, R., Gao, W., Wang, J., Bao, Y., Yang, W., Luo, N., & Li, J. (2020). Ibuprofen mediates histone modification to diminish cancer cell stemness properties via a COX2-dependent manner. British Journal of Cancer, 1–12. https://doi.org/10.1038/s41416-020-0906-7 Cite
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ARS2/MAGL Signaling in Glioblastoma Stem Cells Promotes Self-Renewal and M2-Like Polarization of Tumor-Associated Macrophages
Investigators demonstrated that arsenite-resistance protein 2 (ARS2), a zinc finger protein that is essential for early mammalian development, played critical roles in glioblastoma stem cell maintenance and M2-like tumor-associated macrophage polarization.
[Nature Communications]
Yin, J., Kim, S. S., Choi, E., Oh, Y. T., Lin, W., Kim, T.-H., Sa, J. K., Hong, J. H., Park, S. H., Kwon, H. J., Jin, X., You, Y., Kim, J. H., Kim, H., Son, J., Lee, J., Nam, D.-H., Choi, K. S., Shi, B., … Park, J. B. (2020). ARS2/MAGL signaling in glioblastoma stem cells promotes self-renewal and M2-like polarization of tumor-associated macrophages. Nature Communications, 11(1), 2978. https://doi.org/10.1038/s41467-020-16789-2 Cite
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Unbiased Proteomic Profiling Uncovers a Targetable GNAS/PKA/PP2A Axis in Small Cell Lung Cancer Stem Cells
Scientists identified protein kinase A (PKA) as an active kinase in small cell lung cancer (SCLC). Inhibition of PKA activity genetically, or pharmacologically by activation of the PP2A phosphatase, suppressed SCLC expansion in culture and in vivo.
[Cancer Cell]
Coles, G. L., Cristea, S., Webber, J. T., Levin, R. S., Moss, S. M., He, A., Sangodkar, J., Hwang, Y. C., Arand, J., Drainas, A. P., Mooney, N. A., Demeter, J., Spradlin, J. N., Mauch, B., Le, V., Shue, Y. T., Ko, J. H., Lee, M. C., Kong, C., … Sage, J. (2020). Unbiased Proteomic Profiling Uncovers a Targetable GNAS/PKA/PP2A Axis in Small Cell Lung Cancer Stem Cells. Cancer Cell, 0(0). https://doi.org/10.1016/j.ccell.2020.05.003 Cite
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Targeting FTO Suppresses Cancer Stem Cell Maintenance and Immune Evasion
Researchers showed that genetic depletion and pharmacological inhibition of fat mass and obesity-associated protein dramatically attenuated leukemia stem/initiating cell self-renewal and reprogrammed immune response by suppressing expression of immune checkpoint genes, especially LILRB4.
[Cancer Cell]
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CSL Behring and Seattle Children’s Research Institute to Advance Gene Therapy Treatments for Primary Immunodeficiency Diseases
Seattle Children’s Research Institute and CSL Behring announced a strategic alliance to develop stem cell gene therapies for primary immunodeficiency diseases.
[Seattle Children’s Research Institute]
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SH3RF3 Promotes Breast Cancer Stem-Like Properties via JNK Activation and PTX3 Upregulation
Scientists identified a scaffold protein SH3RF3 that was upregulated in CSCs of breast cancer clinical tumors and cancer cell lines, and enhanced the CSC properties of breast cancer cells.
[Nature Communications]
Ostrander, E. L., Kramer, A. C., Mallaney, C., Celik, H., Koh, W. K., Fairchild, J., Haussler, E., Zhang, C. R. C., & Challen, G. A. (2020). Divergent Effects of Dnmt3a and Tet2 Mutations on Hematopoietic Progenitor Cell Fitness. Stem Cell Reports, 0(0). https://doi.org/10.1016/j.stemcr.2020.02.011 Cite
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Critical Role of SOX2–IGF2 Signaling in Aggressiveness of Bladder Cancer
Researchers found SOX2 expression signifies poor recurrence-free survival and correlates with advanced pathological grade in bladder cancer. SOX2 silencing attenuated bladder cancer cell growth, while its expression promoted cancer cell survival and proliferation.
[Scientific Reports]
Ostrander, E. L., Kramer, A. C., Mallaney, C., Celik, H., Koh, W. K., Fairchild, J., Haussler, E., Zhang, C. R. C., & Challen, G. A. (2020). Divergent Effects of Dnmt3a and Tet2 Mutations on Hematopoietic Progenitor Cell Fitness. Stem Cell Reports, 0(0). https://doi.org/10.1016/j.stemcr.2020.02.011 Cite
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Disrupting Mitochondrial Copper Distribution Inhibits Leukemic Stem Cell Self-Renewal
The authors found increased mRNA expression of mitochondrial intermembrane assembly pathway substrates in acute myeloid leukemia stem cells.
[Cell Stem Cell]
Ostrander, E. L., Kramer, A. C., Mallaney, C., Celik, H., Koh, W. K., Fairchild, J., Haussler, E., Zhang, C. R. C., & Challen, G. A. (2020). Divergent Effects of Dnmt3a and Tet2 Mutations on Hematopoietic Progenitor Cell Fitness. Stem Cell Reports, 0(0). https://doi.org/10.1016/j.stemcr.2020.02.011 Cite
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Integrin-Linked Kinase Mediates Therapeutic Resistance of Quiescent CML Stem Cells to Tyrosine Kinase Inhibitors
Researchers showed integrin-linked kinase, a key constituent of focal adhesions, is highly expressed in TKI-nonresponsive patient cells and their LSCs.
[Cell Stem Cell]
Ostrander, E. L., Kramer, A. C., Mallaney, C., Celik, H., Koh, W. K., Fairchild, J., Haussler, E., Zhang, C. R. C., & Challen, G. A. (2020). Divergent Effects of Dnmt3a and Tet2 Mutations on Hematopoietic Progenitor Cell Fitness. Stem Cell Reports, 0(0). https://doi.org/10.1016/j.stemcr.2020.02.011 Cite
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