Marker Therapeutics Receives USAN Approval for “Zelenoleucel” as Nonproprietary Name for MT-401, Multi-Tumor-Associated Antigen Targeted T Cell Product for Acute Myeloid Leukemia

Marker Therapeutics, Inc. announced that the United States Adopted Names Council has approved “zelenoleucel” as the nonproprietary name for MT-401, a multi-tumor-associated antigen-specific T cell product candidate for the treatment of patients with acute myeloid leukemia following allogeneic stem cell transplant in both adjuvant and active disease settings.
[Marker Therapeutics, Inc.]
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Factors That Predict Delayed Platelet Recovery after Autologous Stem Cell Transplantation for Lymphoma or Myeloma

Platelet recovery following autologous stem cell transplantation (ASCT) was affected by insufficient hematopoietic recovery at stem cell harvest, a need for repeated apheresis, and high fever early after ASCT, particularly when the amount of infused stem cells was insufficient.
[Annals of Hematology]
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Regenerative Potential of Wharton’s Jelly‐Derived Mesenchymal Stem Cells: A New Horizon of Stem Cell Therapy

The authors summarize the current preclinical and clinical studies performed to investigate the regenerative potential of Wharton’s jelly‐derived mesenchymal stem cells in neural, myocardial, skin, liver, kidney, cartilage, bone, muscle, and other tissue injuries.
[Journal of Cellular Physiology]
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Bone Regeneration Capacities of Alveolar Bone Mesenchymal Stem Cells Sheet in Rabbit Calvarial Bone Defect

Scientists compared the osteogenic differentiation and bone defect repairment characteristics of bone marrow mesenchymal stem cells sheets derived from alveolar bone and iliac bone in vitro and in vivo.
[Journal of Tissue Engineering]
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Human Gingiva-Derived Mesenchymal Stem Cells Are Therapeutic in Lupus Nephritis through Targeting of CD39-CD73 Signaling Pathway

Investigators demonstrated that the adoptive transfer of gingiva derived mesenchymal stem cells homes to and maintains in the kidney and had a robust therapeutic effect in a spontaneous lupus nephritis model.
[Journal of Autoimmunity]
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Anti-Relapse Effects of Donor Natural Killer Cells and IL-2 Gene Modification on Allogeneic Hematopoietic Stem Cell Transplantation in Acute Leukemia

The authors investigated whether donor natural killer cells and interleukin-2 gene modification exerted anti-relapse effects on allogeneic hematopoietic stem-cell transplantation after establishing a mouse model of acute leukemia.
[Cancer Biomarkers]
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Engraftment Kinetics after Transplantation of Double Unit Cord Blood Grafts Combined with Haplo-Identical CD34+ Cells without Antithymocyte Globulin

Scientists investigated adding haplo-identical CD34+ cells to double unit cord blood (CB) grafts to facilitate early haplo-identical donor-derived neutrophil recovery prior to CB engraftment.
[Leukemia]
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US Science Groups Wary of New Senate Bills to Curb Foreign Influences

A bipartisan group of US senators proposed sweeping—and controversial—changes in how the federal government manages academic research in the face of threats from other countries.
[ScienceInsider]
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Ligand-Induced Degradation of a CAR Permits Reversible Remote Control of CAR T Cell Activity In Vitro and In Vivo

The authors created a chimeric antigen-receptor (CAR) that was capable of on-demand downregulation by fusing the CAR to a previously developed ligand-induced degradation domain. Addition of a small molecule ligand triggered exposure of a cryptic degron within the ligand-induced degradation domain (LID), resulting in proteasomal degradation of the CAR-LID fusion protein and loss of CAR on the surface of T cells.
[Molecular Therapy]
Ligand-induced degradation of a CAR permits reversible remote control of CAR T cell activity in vitro and in vivo: Molecular Therapy. (n.d.). Retrieved June 16, 2020, from https://www.cell.com/molecular-therapy-family/molecular-therapy/fulltext/S1525-0016(20)30294-X Cite
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Huge Open-Access Journal Deal Inked by University of California and Springer Nature

The University of California (UC) system announced it has signed the biggest open-access deal in North America with one of the largest commercial scientific publishers. The agreement with Springer Nature includes a commitment by the publisher to explore making all articles that UC corresponding authors publish in the Nature family of journals immediately free to read on publication starting in 2022.
[ScienceInsider]
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Quantitative Hybrid Cardiac [18F]FDG-PET-MRI Images for Assessment of Cardiac Repair by Pre-Conditioned Cardiosphere Derived Cells

Scientists enhanced the effect of cardiosphere-derived cells with APOSEC preconditioning (apoCDC), and investigated the reparative effect in a translational pig model of reperfused MI.
[Molecular Therapy-Methods & Clinical Development]
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