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Dermal Cell News
Dermal Cell News is an online resource highlighting the latest research about wound healing, skin disorders, and dermal cancers.
LncRNA SLNCR Phenocopies the E2F1 DNA Binding Site to Promote Melanoma Progression
[Cell Reports] Scientists showed that SLNCR binds to E2F1 to promote the proliferation, invasion, and migration of melanoma cells from the bloodstream into the lungs.
The Dynamic Interplay between Melanoma Cells and CAFs: Implications Drug Resistance and Immune Evasion and Possible Therapeutics
[Experimental Cell Research] The authors explore different subtypes of cancer-associated fibroblasts, their origins, and how they have evolved in their pro-tumorigenic roles in melanoma.
FesariusTherapeutics Announces Manufacturing Agreement for DermiSphere hDRT, the first hydrogel Dermal Regeneration Template
[FesariusTherapeutics, Inc. ] FesariusTherapeutics, Inc. announced it has entered into an exclusive, multi-year manufacturing and supply agreement with Regenity Biosciences. The agreement provides Regenity exclusive manufacturing responsibility for DermiSphere hDRT, an new class of collagen-based dermal regeneration templates.
Blocking Nitrosylation Induces Immunogenic Cell Death by Sensitizing NRAS-Mutant Melanoma to MEK Inhibitors
[Cancer Research] Researchers investigated the role of nitrosylation, a nitric oxide-induced post-translational modification, in melanoma progression and therapeutic resistance.
Rechallenge of Ipilimumab and Nivolumab in Advanced Melanoma Patients after Previous Ipilimumab-Based Therapy
[British Journal of Cancer] Data from advanced melanoma patients rechallenged with ipilimumab+nivolumab after previous ipilimumab-containing treatment were retrieved from the nationwide Dutch Melanoma Treatment Registry.
Stromal Lipid Species Dictate Melanoma Metastasis and Tropism
[Cancer Cell] Researchers showed that abundant stromal lipids from young subcutaneous adipocytes, including phosphatidylcholines, are taken up by melanoma cells, where they upregulate melanoma PI3K-AKT signaling, fatty acid oxidation, oxidative phosphorylation leading to oxidative stress, resulting in decreased metastatic burden.
QPS Expands Offerings With Robust Pharmacology Disease Models, Including MASH, Ulcerative Colitis, Wound Healing, and Psoriasis
[QPS (BioSpace)] QPS is pleased to announce the expansion of its pharmacology disease models portfolio to include highly relevant models for metabolic dysfunction-associated steatohepatitis (MASH), ulcerative colitis, wound healing, and psoriasis.
TREMFYA® (Guselkumab) Receives European Commission Approval for Adults with Moderately to Severely Active Ulcerative Colitis, Strengthening Johnson & Johnson’s Leadership in Inflammatory Bowel Disease
[Johnson & Johnson] Johnson & Johnson announced that the European Commission has approved a Marketing Authorisation for TREMFYA® for the treatment of adult patients with moderately to severely active ulcerative colitis who had an inadequate response, lost response, or were intolerant to either conventional therapy or a biologic treatment.
Noninvasive Transdermal Delivery of STING Agonists Reshapes the Immune Microenvironment of Melanoma and Potentiates Checkpoint Blockade Therapy Efficacy
[ACS Applied Bio Materials] Scientists developed a disulfide-bearing transdermal nanovaccine by integrating a thiol-reactive agent lipoic acid into a metal-coordinated cyclic dinucleotide nanoassembly, designated as LA-Mn-cGAMP nanovaccines.
Is Colloidal Oat an Effective Emollient Ingredient for the Prevention and Treatment of Atopic Dermatitis in Infants?
[Journal of Dermatological Treatment] The authors evaluated clinical and preclinical studies on colloidal oat-containing emollients in pediatric atopic dermatitis (AD) treatment and prevention. Studies assessing skin barrier function, immune modulation, AD prevention, food allergy risk, and healthcare utilization were included.
Aulos Bioscience Doses First Patient in Phase II Cohort Evaluating AU-007 in Combination With Nivolumab for Second-Line Treatment of Melanoma
[AulosTM Bioscience] Aulosâ„¢ Bioscience announced dosing of its first patient with a combination of AU-007, the anti-PD-1 antibody nivolumab, and low-dose, subcutaneous aldesleukin in a Phase II expansion cohort focused on second-line treatment of melanoma.
A Dynamically Phase-Adaptive Regulating Hydrogel Promotes Ultrafast Anti-Fibrotic Wound Healing
[Nature Communications] A dynamically Schiff base-crosslinked hydrogel (F/R gel) with phase-adaptive regulating functions was constructed to integratedly promote rapid re-epithelialization with suppressed scars on chronic infected wounds.
As the largest organ in the human body, the skin is implicated in a wide range of health conditions. Dermal Cell News is dedicated to covering it all. Our website, newsletter, and Twitter feed highlight research on tissue regeneration in the treatment of skin wounds, burns, cancers, and disorders. We also feature relevant job postings and upcoming events.
