Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
Dermal Cell News
Dermal Cell News is an online resource highlighting the latest research about wound healing, skin disorders, and dermal cancers.
The Role and Mechanism of Engineered Nanovesicles Derived from Hair Follicle Mesenchymal Stem Cells in the Treatment of UVB-Induced Skin Photoaging
[Journal of Cosmetic Dermatology] Ultraviolet radiation B (UVB)-induced photoaging nude mice and human dermal fibroblasts were used as experimental models to investigate the therapeutic effects of cell-derived nanovesicles from hair follicle mesenchymal stem cells in photoaging models.
Transcription Factor Activating Enhancer-Binding Protein 2ε (AP2ε) Modulates Phenotypic Plasticity and Progression of Malignant Melanoma
[Cell Death & Disease] Using a transgenic melanoma mouse model with a specific loss of AP2ε expression, researchers confirmed the impact of AP2ε to modulate the dynamic switch from a migratory to a proliferative phenotype.
Exosome-Mimetic Vesicles Derived From Fibroblasts Carrying Matrine for Wound Healing
[Burns & Trauma] Scientists utilized gradient extrusion to produce fibroblast-derived exosome-mimetic vesicles as carriers for matrine (MHEM), and the therapeutic effect of MHEM in wound healing was explored in vitro and in vivo.
Three Stepwise pH Progressions in Stratum Corneum for Homeostatic Maintenance of the Skin
[Nature Communications] Researchers used intravital pH imaging at single-corneocyte resolution to demonstrate that corneocytes undergo differentiation to develop three distinct zones in the stratum corneum, each with a distinct pH value.
TASL Mediates Keratinocyte Differentiation by Regulating Intracellular Calcium Levels and Lysosomal Function
[Scientific Reports] Scientists discovered that TLR adaptor interacting with solute carrier family 15 member 4 on the lysosome (TASL) deficiency hindered the proliferation and migration of keratinocytes by inducing G1/S cell cycle arrest.
MLKL, a New Actor of UVB-Induced Apoptosis in Human Diploid Dermal Fibroblasts
[Cell Death Discovery] Investigators evaluated the implication of receptor-interacting serine/threonine-protein kinase 3 (RIPK3) and mixed lineage kinase domain-like (MLKL) in ultraviolet radiation (UV) B-induced cell death in human diploid dermal fibroblasts, and reported that RIPK3 and MLKL played opposite roles in UVB-induced cell death, in a necroptosis independent pathway.
Dermal Dive: An Overview of Cutaneous Wounding Techniques in Zebrafish
[Journal Of Investigative Dermatology] Scientists review some of the techniques that have been developed for eliciting cutaneous wounds in the zebrafish, including an economical method they recently developed using a rotary tool that generates consistent and reproducible full-thickness wounds.
A Proof-of-Concept Study of Sequential Treatment with the HDAC Inhibitor Vorinostat Following BRAF and MEK Inhibitors in BRAFV600 mutated Melanoma
[Clinical Cancer Research] Scientists assessed the anti-tumor activity of sequential treatment with vorinostat following BRAF and MEK inhibitors (BRAFi/MEKi) in patients with BRAFV600 melanoma who progressed after initial response to BRAFi/MEKi.
H2A.Z Chaperones Converge on E2F Target Genes for Melanoma Cell Proliferation
[Genes & Development] Researchers showed that individual subunit depletion of SRCAP, P400, and VPS72 resulted in not only the loss of H2A.Z deposition into chromatin but also a reduction of H4 acetylation in melanoma cells.
Twist2 Contributes to Skin Regeneration and Hair Follicle Formation in Mouse Fetuses
[Scientific Reports] Scientists elucidated Twist2 expression and its role in fetal wound healing. Mouse fetuses were surgically wounded, and Twist2 expression in tissue samples from these fetuses were evaluated via in situ hybridization, immunohistochemistry, and reverse transcription-quantitative polymerase chain reaction.
circCDK13-Loaded Small Extracellular Vesicles Accelerate Healing in Preclinical Diabetic Wound Models
[Nature Communications] Scientists demonstrated that circCDK13 could stimulate the proliferation and migration of human dermal fibroblasts and human epidermal keratinocytes by interacting with insulin-like growth factor 2 mRNA binding protein 3 in an N6-Methyladenosine-dependent manner to enhance CD44 and c-MYC expression.
Recycled Melanoma-Secreted Melanosomes Regulate Tumor-Associated Macrophage Diversification
[EMBO Journal] Scientists reported that melanoma-secreted melanosomes passaged through epidermal keratinocytes or dermal fibroblasts could be further engulfed by resident macrophages, which led to macrophage polarization into pro-tumor or pro-immune cell infiltration phenotypes.
As the largest organ in the human body, the skin is implicated in a wide range of health conditions. Dermal Cell News is dedicated to covering it all. Our website, newsletter, and Twitter feed highlight research on tissue regeneration in the treatment of skin wounds, burns, cancers, and disorders. We also feature relevant job postings and upcoming events.
