Endothelial Cell News

Endothelial Cell News is an online resource dedicated to the latest research studying the endothelium, blood vessels, and angiogenesis.

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Endothelial Sensitivity to Pro-Fibrotic Signals Links Systemic Exposure to Pulmonary Fibrosis

July 7, 2025

[Cell Death & Disease] Researchers investigated early transcriptomic and secretory responses of HUVECs to subtoxic doses of bleomycin, a known pro-fibrotic agent, and TGF-beta, a key cytokine in fibrosis.

Iridex Announces First Patient Enrolled in an Independent Landmark Investigator-Led UK Study Evaluating MicroPulse® Technology as an Adjunct to anti-VEGF Therapy for Diabetic Macular...

July 7, 2025

[Iridex Corporation (BioSpace)] Iridex Corporation announced that the first patient has been enrolled in the investigator-led DAME Trial to evaluate the clinical efficacy, safety, cost-effectiveness, and patient acceptability of adding subthreshold MicroPulse treatments to anti-vascular endothelial growth factor therapy in patients presenting with severe diabetic macular edema.

Blood‑Brain Barrier Dysfunction in Epilepsy: Mechanisms, Therapeutic Strategies, and Future Orientation

July 7, 2025

[International Journal of Molecular Medicine] The authors review the critical role of the blood-brain barrier (BBB) in the pathogenesis of epilepsy, untangle the complex association between BBB dysfunction and the course of the disease, and explore new approaches for epilepsy prevention and treatment from a BBB perspective.

TGF-β Inhibition Restores Hematopoiesis and Immune Balance via Bone Marrow EPCs in Aplastic Anemia

July 2, 2025

[Experimental & Molecular Medicine] Scientists find that transforming growth factor-β (TGF-β) signaling is hyperactive in dysfunctional aplastic anemia endothelial progenitor cells (EPCs) with impaired hematopoietic support and immune regulatory ability, and TGF-β inhibition promotes hematopoiesis and immune rebalance by repairing dysfunctional EPCs.

Vamp3/Syntaxin 4 Mediates the Basolateral Membrane Fusion of TfR Transcytosis across the BBB and Is Exploited by Pathogenic E. coli

July 2, 2025

[Proceedings of The National Academy of Sciences of The United States of America] Investigators found that the interaction between VAMP3 on transferrin receptor (TfR) vesicles and syntaxin 4 at the basolateral membrane of brain microvascular endothelial cells mediates the final fusion step of TfR transcytosis.

Endothelial Cells Expressing CPE and vWF Are Involved in the Immunopathogenesis of Primary Biliary Cholangitis

July 2, 2025

[Scientific Reports] scRNA-seq data were initially analyzed using R statistical software and Cell Ranger. Differentially expressed genes and marker genes were identified using Seurat.

Loss of Endothelial ZEB2 in Mice Attenuates Steatosis Early during Metabolic Dysfunction-Associated Steatotic Liver Disease

July 2, 2025

[Scientific Reports] To investigate a potential protective role against steatosis, the initial metabolic dysfunction-associated steatotic liver disease stage, researchers fed endothelial cell-specific Zeb2 knockout mice a western-type diet.

AGGF1-Primed Endothelial Progenitor Cells Alleviate Ischaemia-Reperfusion Injury in Diabetic Hearts

July 2, 2025

[Scientific Reports] The authors observed that the damaging effects of hyperglycemia + hypoxia/reoxygenation on endothelial progenitor cells were abolished by angioGenic factor with a G-patch domain and a Forkhead-associated domain 1 (AGGF1).

Remdesivir Inhibits Endothelial Activation and Atherosclerosis by Coupling TAL1 to TRAF6

July 2, 2025

[Journal of Translational Medicine] Pharmacological treatment with remdesivir significantly reduced atherosclerotic lesions in the total aorta and decreased VCAM-1 expression in aortic roots of ApoE−/− mice.

Nanosilicates Promote Angiogenesis through Activation of ROS-Mediated WNT/β-catenin Pathway

July 2, 2025

[Science Advances] Researchers introduced nanosilicates as proangiogenic biomaterials that can prime endogenous cells to expedite angiogenesis and graft vascularization in vivo.

Sphingosine-1-Phosphate (S1P) in Whole Liver Recellularization Improves Endothelization of Acellular Liver Scaffold

June 27, 2025

[ACS Biomaterials Science & Engineering] Researchers presented a novel approach to enhance the re-endothelialization of decellularized rat liver scaffolds by seeding HUVECs in the presence of S1P, aiming to bioengineer a fully endothelialized liver.

3D Brain Vascular Niche Model Captures Glioblastoma Infiltration, Dormancy, and Gene Signatures

June 26, 2025

[Advanced Science] A multicellular approach was employed using human glia and vascular cells to optimize a 3D brain vascular niche model that enables not only long-term culture of patient derived glioblastoma (GBM) cells but also recapitulation of key features of GBM heterogeneity.

Specific research topics covered in Endothelial Cell News include the roles of endothelial cells in the regulation of physiological processes, as well as their implications in tumor progression, cardiovascular disease, endometriosis, wound healing, tissue regeneration and other diseases and disorders. We also provide updates on the latest job postings and upcoming events, helping connect everyone within the endothelial cell research field.