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Endothelial Cell News
Endothelial Cell News is an online resource dedicated to the latest research studying the endothelium, blood vessels, and angiogenesis.
Hyperlipidemia-Induced Hematopoiesis Is Repressed by MLKL in Endothelial Cells of the Splenic Niche
[Nature Cardiovascular Research] Researchers showed unique dysregulated pathways in splenic compared to bone marrow endothelial cells during atherosclerosis, including perturbations of lipid metabolism and endocytic trafficking pathways.
FOXC1 Regulates Endothelial CD98 (LAT1/4F2hc) Expression in Retinal Angiogenesis and Blood-Retina Barrier Formation
[Nature Communications] Investigators showed that FOXC1 was essential for retinal angiogenesis. Endothelial cell-specific loss of Foxc1 impaired retinal vascular growth and expression of Slc3a2 and Slc7a5, which encoded the heterodimeric CD98 amino acid transporter and regulated the intracellular transport of essential amino acids and activation of the mammalian target of rapamycin.
Direct Conversion of Cardiac Fibroblasts Into Endothelial-Like Cells Using Sox17 and Erg
[Nature Communications] Scientists reported a Sox17-Erg direct reprogramming approach that used cardiac fibroblasts to create differentiated endothelial cells that demonstrated endothelial-like molecular and physiological functions in vitro and in vivo.
Adrenomedullin Improved Endothelial Dysfunction via Receptor-Akt Pathway in Rats With Obesity-Related Hypertension
[Hypertension Research] The obesity-related hypertension rats induced by high-fat diet for 28 weeks and the human umbilical vein endothelial cells-treated by palmitic acid were used to investigate the effects of adrenomedullin on endothelial dysfunction and the underlying mechanisms.
HYPOXIA Induces lncRNA HOTAIR for Recruiting RELA in Papillary Thyroid Cancer Cells to Upregulate miR-181a and Promote Angiogenesis
[Journal Of Endocrinological Investigation] Scientists examined the regulatory mechanism of miR-181a under conditions of hypoxia and its impact on angiogenesis. The regulatory effect of GATA6 on angiogenesis was studied using CCK8, EdU, Transwell, and western blot assays.
The Mechanosensory Channel PIEZO1 Functions Upstream of Angiopoietin/TIE/FOXO1 Signaling in Lymphatic Development
[Journal Of Clinical Investigation] Investigators identified crosstalk between piezo-type mechanosensitive ion channel component 1 (PIEZO1), angiopoietin 2 (ANGPT2), and tyrosine kinase with Ig-like and EGF-like domains 1 (TIE1) and showed that activation of the mechanosensory channel PIEZO1 in lymphatic endothelial cells caused rapid exocytosis of the TIE ligand ANGPT2 and more.
Novel Angiogenesis Inhibitors with Superoxide Anion Radical Amplification Effect: Surmounting the Achilles’ Heels of Angiogenesis Inhibitors and Photosensitizers
[European Journal Of Medicinal Chemistry] 11 novel angiogenesis inhibitors were developed through hybridization strategy to overcome their clinical limitations. These title compounds boast excitation wavelengths within the “therapeutic window”, enabling deep tissue penetration.
CCL4 Contributes to Aging Related Angiogenic Insufficiency through Activating Oxidative Stress and Endothelial Inflammation
[Angiogenesis] Scientists hypothesized that chemokine C-C motif ligands 4 (CCL4) might play a vital role in aging-related vascular dysfunction. Circulating CCL4 was up-regulated in elderly subjects and in aged animals.
Engineered Nanomicelles Targeting Proliferation and Angiogenesis Inhibit Tumour Progression by Impairing the Synthesis of Ceramide-1-Phosphate
[Nanoscale] Researchers engineered sub-100 sized nanomicelles targeting proliferation and angiogenesis using an esterase-sensitive phosphocholine-tethered docetaxel conjugate of lithocholic acid (LCA) and a poly(ethylene glycol) derivative of an LCA–combretastatin A4 conjugate.
Estrogen Stimulates Fetal Vascular Endothelial Growth Factor Expression and Microvascularization
[Journal Of Endocrinology] Investigators showed that estrogen upregulates skeletal muscle VEGF expression and systemic microvessel development within the fetus as an essential programming event critical for ontogenesis of systemic vascular function and insulin sensitivity/glucose homeostasis after birth in primate offspring.
New Insights in ATP Synthesis as Therapeutic Target in Cancer and Angiogenic Ocular Diseases
[Journal Of Histochemistry & Cytochemistry] During angiogenesis in non-cancerous tissue, proliferating stalk endothelial cells (ECs) produce lactate and ATP by aerobic glycolysis. Local treatment of angiogenic eye conditions with inhibitors of glycolysis may be a safe therapeutic option that warrants experimental investigation.
Firms Offering a Fast Track to Publication Target Foreign Applicants to US Medical Residency Programs
[Science Insider] Based in Atlanta, Desai runs a business that offers junior doctors from around the world a chance to beef up their CVs before applying for coveted residency or fellowship positions at hospitals or physician offices in the United States.
Specific research topics covered in Endothelial Cell News include the roles of endothelial cells in the regulation of physiological processes, as well as their implications in tumor progression, cardiovascular disease, endometriosis, wound healing, tissue regeneration and other diseases and disorders. We also provide updates on the latest job postings and upcoming events, helping connect everyone within the endothelial cell research field.
