ESC & iPSC News

ESC & iPSC News is an online resource dedicated to the latest research in the fields of embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs).

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City of Hope Awarded $5.4 Million CIRM Grant to Create a Stem Cell Laboratory and Expand Access to State-of-the-Art Disease Models and Technology Among...

May 23, 2024

[City of Hope] City of Hope, one of the largest cancer research and treatment organizations in the United States, has been awarded $5.4 million from the California Institute for Regenerative Medicine (CIRM) to build and fund a stem cell research laboratory on its Duarte, California, campus that will further expand its scientific capabilities.

Human iPSC and CRISPR Targeted Gene Knock-In Strategy for Studying the Somatic TIE2L914F Mutation in Endothelial Cells

May 22, 2024

[Angiogenesis] To study the effects of targeted mutations on an endogenous level, scientists generated and characterized an iPSC derived model for venous malformations (VMs). CRISPR-Cas9 technology was used to generate a novel human iPSC line with an amino acid substitution L914F in the TIE2 receptor, known to cause VMs.

Superior Induced Pluripotent Stem Cell Generation through Phactr3-Driven Mechanomodulation of Both Early and Late Phases of Cell Reprogramming

May 22, 2024

[Biomaterials Research] Researchers found that a medium stiffness gel increased the overall number of reprogrammed cells by up to 10-fold, accelerated reprogramming kinetics and produced iPSCs having more naïve characteristics and lower remnant transgene expression, compared to the gold standard tissue culture polystyrene practice.

Ultrasound-Triggered Three Dimensional Hyaluronic Acid Hydrogel Promotes In Vitro and In Vivo Reprogramming Into Induced Pluripotent Stem Cells

May 22, 2024

[Bioactive Materials] Scientists presented a new reprogramming strategy using low-intensity ultrasound to improve cellular reprogramming of iPSCs in vitro and in vivo.

Generation of Induced Pluripotent Stem Cell Lines From Patients With LQT1 Caused by Heterozygous Mutations in the KCNQ1 Gene

May 22, 2024

[Stem Cell Research] Investigators generated two LQT1 iPSC lines with single nucleotide nonsense mutations, c.1031 C > T and c.1121 T > A in KCNQ1. Both lines exhibited typical iPSC morphology, expressed high levels of pluripotent markers, maintained normal karyotype, and possessed the capability to differentiate into three germ layers.

Generation of Induced Pluripotent Stem Cells From an Individual with Early Onset and Severe Hypertrophic Cardiomyopathy Linked to MYBPC3: c.772G > a Mutation

May 22, 2024

[Human Cell] Researchers generated two iPSC lines from peripheral blood mononuclear cells of a female with early onset and severe hypertrophic cardiomyopathy linked to the MYBPC3: c.772G > A variant.

Establishing a Human-Induced Pluripotent Stem Cell Line SMUSHi005-A From a Patient with Hypophosphatemic Vitamin D-Resistant Rickets Carrying the PHEX c.1586–1586+1 delAG Mutation

May 22, 2024

[Stem Cell Research] The SMUSHi005-A hiPSC line was successfully established from the peripheral blood mononuclear cells of a female patient carrying the PHEX mutation with c.1586–1586+1 delAG. The iPSC line has been confirmed to have a normal karyotype.

Epigenetic Inheritance of Acquired Traits via Stem Cells Dedifferentiation/Differentiation or Transdifferentiation Cycles

May 22, 2024

[Cells & Development] The authors hypothesize existence of pluripotent adult stem cells that can serve as collectors and carriers of new epigenetic traits by entering different developmentally active organ/tissue compartments through blood circulation and acquiring new epigenetic marks though cycles of differentiation/dedifferentiation or transdifferentiation.

Parkinson’s Patient Moves Freely Again after World-First Implant of Lab-Grown Cells Into His Brain

May 22, 2024

[STEM-PD] Researchers at Lund University have successfully implanted 7 million lab-grown brain cells into a patient to treat Parkinson's disease. Swedish resident Thomas Matsson was the first in the world to test the method about a year ago

Smad4 Is Essential for Epiblast Scaling and Morphogenesis after Implantation, but Nonessential Prior to Implantation in Mouse

May 17, 2024

[Development] Investigators showed that, in contrast to prior reports, bone morphogenic protein signaling (SMAD1/5/9 phosphorylation) is not detectable until implantation when it is detected in the primitive endoderm – an extraembryonic lineage.

GPR160 Regulates the Self-Renewal and Pluripotency of Mouse Embryonic Stem Cells via JAK1/STAT3 Signal Pathway

May 17, 2024

[Journal of Genetics and Genomics] Scientists showed that GPR160, a class A member of G protein-coupled receptors, was dramatically downregulated concurrent with mESC differentiation into embryoid bodies in vitro.

Enhancing Genome Editing in hPSCs through Dual Inhibition of DNA Damage Response and Repair Pathways

May 16, 2024

[Nature Communications] Researchers demonstrated that dual inhibition of p53-mediated cell death and distinct activation of the DNA damage repair system upon DNA damage by cytosine base editor or prime editor additively enhanced editing efficiency in hPSCs.

Since 2007, ESC & iPSC News has been providing updates on the top publications, reviews, and news in pluripotent stem cell research. Through our website, Twitter, and email newsletters, our editorial team is proud to help keep researchers and medical professionals up-to-date with the latest discoveries, jobs, and event postings in the pluripotent stem cell field.