Superior Induced Pluripotent Stem Cell Generation through Phactr3-Driven Mechanomodulation of Both Early and Late Phases of Cell Reprogramming

Researchers found that a medium stiffness gel increased the overall number of reprogrammed cells by up to 10-fold, accelerated reprogramming kinetics and produced iPSCs having more naïve characteristics and lower remnant transgene expression, compared to the gold standard tissue culture polystyrene practice.