ESC & iPSC News

ESC & iPSC News is an online resource dedicated to the latest research in the fields of embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs).

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KIF2A Stabilizes Intercellular Bridge Microtubules to Maintain Mouse Embryonic Stem Cell Cytokinesis

May 12, 2025

[Journal of Cell Biology] Scientists described a novel function for the kinesin-13 member KIF2A in cytokinesis. In genome-engineered mESCs, they found that KIF2A localizes to spindle poles during metaphase and regulates spindle length in a manner consistent with its known role as a microtubule minus-end depolymerase.

Leveraging CRISPR Activation for Rapid Assessment of Gene Editing Products in Human Pluripotent Stem Cells

May 12, 2025

[Stem Cell Reports] Scientists established a rapid and effective workflow for verifying genome-edited hPSC lines targeting unexpressed genes using CRISPR-mediated transcriptional activation.

Advancements in Stem Cell Research for Effective Therapies against Alzheimer’S Disease: Current Investigation and Future Insight

May 12, 2025

[Molecular Neurobiology] The authors explore the potential of stem cell-based therapies in Alzheimer’s disease, emphasizing the necessity for continued innovation to overcome existing challenges and enhance therapeutic efficacy.

ATR Regulates OCT4 Phosphorylation and Safeguards Human Naïve Pluripotency

May 6, 2025

[Scientific Reports] Scientists systematically mapped out phosphorylation sites in OCT4 protein that are differentially phosphorylated between two states of pluripotency, and further identified ATR as a key kinase that phosphorylated OCT4 in naïve but not primed hESCs.

Stem Cells As Role Models for Reprogramming and Repair

May 6, 2025

[Science] The authors review principles of mammalian stem cell biology and cellular reprogramming approaches and their use for current and future therapeutic purposes.

Rewiring of SINE-MIR Enhancer Topology and Esrrb Modulation in Expanded and Naive Pluripotency

April 30, 2025

[Genome Biology] Researchers explored the utilization of transposable elements (TE)-derived enhancers in naïve and expanded pluripotent states by integrative analysis of genome-wide Hi-C-defined enhancer interactions, H3K27ac HiChIP profiling, and CRISPR-guided TE proteomics landscape.

Moving toward Totipotency: The Molecular and Cellular Features of Totipotent and Naive Pluripotent Stem Cells

April 30, 2025

[Human Reproduction Update] The authors follow the PRISMA guidelines, survey the current works of literature on totipotent, naive, and formative PSCs, introduce the molecular and biological characteristics of those stem cells, and give advice for future research.

A Cross-Linked Cyclosiloxane Polymer Matrix as a Platform Enabling Long-Term Culture of Human Induced Pluripotent Stem Cells with Naïve-Like Features

April 30, 2025

[Biomaterials Research] The authors developed a long-term hiPSC culture platform based on a cross-linked cyclosiloxane polymer matrix that preserves pluripotency with naïve-like characteristics.

METTL3-Dependent m6A RNA Methylation Regulates Transposable Elements and Represses Human NaïVe Pluripotency through Transposable Element-Derived Enhancers

April 30, 2025

[Nucleic Acids Research] Using a METTL3 inducible knockout system, researchers uncovered that, unlike in mESCs, METTL3 was indispensable for hPSC maintenance.

The Establishment of Nuclear Organization in Mouse Embryos Is Orchestrated by Multiple Epigenetic Pathways

April 30, 2025

[Cell] Investigators performed a gain-of-function screen in mouse embryos to obtain mechanistic insights.

Derivation of Mesenchymal Stem Cells through Sequential Presentation of Growth Factors via Gelatin Microparticles in Pluripotent Stem Cell Spheroids

April 30, 2025

[Biomaterials Research] Investigators developed two types of gelatin microparticles with distinct degradation rates for sequential delivery of growth factors to enhance differentiation while preventing necrotic zones.

Maturation of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes Promoted by Brachyury Priming

April 30, 2025

[Scientific Reports] A mesoderm priming approach was engineered to boost the maturation of cardiomyocyte progeny derived from PSCs under standard cardiac differentiation conditions.

Since 2007, ESC & iPSC News has been providing updates on the top publications, reviews, and news in pluripotent stem cell research. Through our website, Twitter, and email newsletters, our editorial team is proud to help keep researchers and medical professionals up-to-date with the latest discoveries, jobs, and event postings in the pluripotent stem cell field.