Extracellular Matrix News

Extracellular Matrix News is an online resource that keeps scientists updated on the latest extracellular matrix research.

Fibroblast Alignment and Matrix Remodeling Induced by a Stiffness Gradient in a Skin-Derived Extracellular Matrix Hydrogel

[Acta Biomaterialia] Using a custom mold, skin-derived ECM hydrogels (dECM) were UV crosslinked after diffusion of ruthenium (Ru) to produce a Ru-dECM gradient hydrogel.

Mikkael Lamoca Receives Fulbright Scholarship to Complete Cutting-Edge STEM Cell Research

[Rochester Institute of Technology] Lamoca’s award will fund a ten-month research experience in the BioIonic Currents Electromagnetic Pulsing Systems Laboratory at the National University of Singapore. His research focuses on age-related neurodegeneration, which can be seen in Alzheimer’s disease, dementia, and other conditions.

Wall Shear Stress Measured with 4D Flow CMR Correlates with Biomarkers of Inflammation and Collagen Synthesis in Mild-to-Moderate Ascending Aortic Dilation and Tricuspid Aortic...

[European Heart Journal-Cardiovascular Imaging] Researchers explored associations between ascending aortic hemodynamics, assessed using four-dimensional flow cardiovascular magnetic resonance imaging, and circulating biomarkers in aortic dilation.

Mechanotransduction in Stem Cells

[European Journal Of Cell Biology] The authors report what is currently known about these elements in general and their specific interplay in the context of multi- and pluripotent stem cells.

Synergistic Antitumor Activity by Dual Blockade of CCR1 and CXCR2 Expressed on Myeloid Cells within the Tumor Microenvironment

[British Journal Of Cancer] Investigators generated double-knockout mice for CCR1 and CXCR2, and performed bone marrow transfer experiments in which sub-lethally irradiated wild-type mice were reconstituted with bone marrow from either wild-type, Ccr1−/−, Cxcr2−/− or Ccr1−/−Cxcr2−/− mice.

Confined Bioprinting and Culture in Inflatable Bioreactor for the Sterile Bioproduction of Tissues and Organs

[Scientific Reports] The authors introduced a novel device called the Flexible Unique Generator Unit, which is a unique combination of flexible silicone membranes and solid components made of stainless steel.

Navigating the Tumor Microenvironment: Mesenchymal Stem Cell-Mediated Delivery of Anticancer Agents

[Journal Of Drug Targeting] The authors elaborates on recent advancements of mesenchyma stem cell mediated drug delivery of anti-cancer agents along with its mechanism and previously reported studies of drugs manufactured via this drug delivery system.

Engineering Cell Instructive Microenvironments for In Vitro Replication of Functional Barrier Organs

[Advanced Healthcare Materials] The authors explored current limitations to in vitro organ morphogenesis, emphasizing the interplay of gene regulatory networks, mechanical factors, and tissue microenvironment cues.

RNA Aggregates Harness the Danger Response for Potent Cancer Immunotherapy

[Cell] Researchers created “onion-like” multi-lamellar RNA lipid particle aggregates to substantially enhance the payload packaging and immunogenicity of tumor mRNA antigens.

Histological and Immunohistochemical Analyses of Articular Cartilage During Onset and Progression of Pre- and Early-Stage Osteoarthritis in a Rodent Model

[Scientific Reports] On postoperative day three, histological changes, including chondrocyte death, reduced matrix staining, and superficial fibrillation, were observed. Simultaneously, a compensatory increase in matrix staining was observed.

Fibroblast Expression of Transmembrane Protein Smoothened Governs Microenvironment Characteristics After Acute Kidney Injury

[Journal Of Clinical Investigation] Researchers reported that Smo-specific ablation in fibroblasts reduced tubular cell apoptosis and inflammation, enhanced perivascular mesenchymal cells activities, and preserved kidney function after acute kidney injury.

Brain Delivery of Protein Therapeutics by Cell Matrix-inspired Biomimetic Nanocarrier

[Advanced Materials] Inspired by the natural environment of active proteins, scientists used the cell matrix components hyaluronic acid and protamine to self-assemble with proteins to form a protein-loaded biomimetic core and then incorporated it into ApoE3-reconstituted high-density lipoprotein to form a protein-loaded biomimetic nanocarrier.

The Extracellular Matrix News team is proud to provide an essential resource on the latest publications, reviews, industry news, and jobs relevant to the matrix research community. Topics include extracellular matrix-cell interactions, extracellular matrix protein characterization and their application in tissue engineering and regenerative medicine, and the development and characterization of synthetic scaffolds.

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