Emmes Announces Its Work on a Phase III Clinical Trial for Breakthrough Therapy Designation Product

Emmes announced that it provided the Phase III clinical trial support for a new investigational cell therapy that offers a promising treatment opportunity for patients who need an allogeneic bone marrow transplant.
[Emmes (PR Newswire, Inc.)]
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Allogeneic Cord Blood Transfusions Prevent Fetal Haemoglobin Depletion in Preterm Neonates. Results of the CB-TrIP Study

Investigators monitored fetal haemoglobin levels in 25 preterm neonates until 36 weeks of post‐menstrual age; patients received repeated red blood cell (RBC) units from allogeneic cord blood (cord‐RBCs) or from adult donors, depending on whether cord‐RBCs were available.
[British Journal of Haematology]
Teofili, L., Papacci, P., Orlando, N., Bianchi, M., Molisso, A., Purcaro, V., … Stefano, V. D. (n.d.). Allogeneic cord blood transfusions prevent fetal haemoglobin depletion in preterm neonates. Results of the CB-TrIP study. British Journal of Haematology, n/a(n/a). https://doi.org/10.1111/bjh.16851 Cite
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Single-Cell RNA-Seq Mapping of Human Thymopoiesis Reveals Lineage Specification Trajectories and a Commitment Spectrum in T Cell Development

Scientists used single-cell RNA sequencing to interrogate the rare CD34+ progenitor and the more differentiated CD34 fractions in the human postnatal thymus.
[Immunity]
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Enhanced Collection of Phenotypic and Engrafting Human Cord Blood Hematopoietic Stem Cells at 4°C

Researchers demonstrated that collecting and processing of human cord blood at 4°C within minutes of the baby’s birth results in significantly enhanced numbers of rigorously defined phenotypic hematopoietic stem cell and self‐renewing NSG immune‐deficient mouse engrafting and SCID‐repopulating cells.
[Stem Cells]
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Fabrication of Stiffness Gradients of GelMA Hydrogels using a 3D Printed Micromixer

A co-culture consisting of human adipose tissue-derived mesenchymal stem cellsand human umbilical cord vein endothelial cells was encapsulated in the gradient construct.
[Macromolecular Bioscience]
Lavrentieva, A., Fleischhammer, T., Enders, A., Pirmahboub, H., Bahnemann, J., & Pepelanova, I. (n.d.). Fabrication of Stiffness Gradients of GelMA Hydrogels Using a 3D Printed Micromixer. Macromolecular Bioscience, n/a(n/a), 2000107. https://doi.org/10.1002/mabi.202000107 Cite
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Huge Open-Access Journal Deal Inked by University of California and Springer Nature

The University of California (UC) system announced it has signed the biggest open-access deal in North America with one of the largest commercial scientific publishers. The agreement with Springer Nature includes a commitment by the publisher to explore making all articles that UC corresponding authors publish in the Nature family of journals immediately free to read on publication starting in 2022.
[ScienceInsider]
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BCG Vaccination in Humans Elicits Trained Immunity via the Hematopoietic Progenitor Compartment

Researchers showed that Bacille-Calmette-Guérin vaccination in healthy human volunteers induced a persistent transcriptional program connected to myeloid cell development and function within the hematopoietic stem and progenitor cell compartment in the bone marrow.
[Cell Host & Microbe]
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Partner Therapeutics Announces Initiation of Clinical Trial Evaluating Leukine® in T Cell Replete HLA-mismatched Haploidentical Stem Cell Transplant

Partner Therapeutics announced the enrollment of the first patient dosed in a Phase II investigator-initiated study evaluating the efficacy and safety of Leukine® in T cell replete HLA-mismatched haploidentical stem cell transplant recipients who are receiving post-transplant cyclophosphamide.
[Partner Therapeutics, Inc.]
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Curis Announces FDA Clearance of IND Application for CI-8993, the First-In-Class Monoclonal Anti-VISTA Antibody

Curis, Inc. announced that the FDA has cleared its Investigational New Drug (IND) application for CI-8993, the first-in-class monoclonal anti-VISTA antibody.
[Curis, Inc.]
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Risk Score to Predict Event-Free Survival after Hematopoietic Cell Transplant for Sickle Cell Disease

Investigators developed a risk score to predict event-free survival after allogeneic hematopoietic cell transplantation for sickle cell disease.
[Blood]
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MicroRNAs in Hematopoietic Stem Cell Aging

The authors discuss the role of miRs in the regulation of HSC self-renewal and differentiation throughout life and its implications for future research.
[Mechanisms of Ageing and Development]
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