The Career Cost of COVID-19 to Female Researchers, and How Science Should Respond

Early data on the effects of the coronavirus pandemic on scientific-publishing output suggest that female researchers, particularly those at early-career stages, are the hardest hit. Submissions to preprint servers, such as arXiv, rose more quickly for male authors than for female authors as nations adopted social-isolation measures.
[Nature News]
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EU Leaders Slash Science Spending in €1.8 Trillion Deal

Following a marathon EU summit in Brussels, national leaders agreed to a €1.8 trillion, seven-year budget and pandemic recovery fund that will spend €81 billion on Horizon Europe, the main EU research program.
[Science Insider]
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‘Ethically Troubling.’ University Reopening Plans Put Professors, Students on Edge

Come August, hundreds of universities across the United States are poised to reopen their campuses with a mix of online and in-person courses. Only a handful are aiming for an entirely online semester. But as the machinery of higher education cranks back into action, faculty, staff, and students are voicing concerns that, with COVID-19 cases surging in many parts of the country, employees are being forced to put their health—and the health of others—at unnecessary risk.
[ScienceInsider]
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Pioneering Duplication Detector Trawls Thousands of Coronavirus Preprints

Amid concerns that the torrent of research papers on COVID-19 could be leading to an excess of sloppy work, a computer scientist who develops automated programs to spot duplicate images in research papers is running his software across the world’s coronavirus preprints. So far, his efforts have yielded mixed success and some controversy.
[Nature News]
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Characteristics of Cells with Engraftment Capacity within CD34+ Cell Population upon G-CSF and Plerixafor Mobilization

Investigators assessed the hematopoietic stem cell content within the CD34+ fraction of graft samples from three groups of patients: 1-Good Mobilizer patients receiving G-CSF only, 2-Poor Mobilizer (PM) patients receiving G-CSF only, 3-PM patients receiving G-CSF + Plerixafor.
[Leukemia]
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Determinants and Role of Chromatin Organization in Acute Leukemia

The authors provide detailed discussion of the nature of 3D interactions and the way that they are disrupted in acute leukemia.
[Leukemia]
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Preeclampsia in Pregnancy Affecting the Stemness and Differentiation Potency of Hematopoietic Stem Cells of the Umbilical Cord Blood

Scientists investigated the effects of preeclampsia in pregnancy on the stemness and differentiation potency of umbilical cord blood-hematopoietic stem cells.
[BMC Pregnancy and Childbirth]
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TLR2/6 Signaling Promotes the Expansion of Premalignant Hematopoietic Stem and Progenitor Cells in the NUP98HOXD13 Mouse Model of MDS

Researchers tested the effects of specific modulation of Toll like receptor (TLR)1/2 versus TLR2/6 signaling on premalignant hematopoietic stem and progenitor cells.
[Experimental Hematology]
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BMP Signaling Is Required For Postnatal Murine Hematopoietic Stem Cell Self-Renewal

Scientists establish that bone morphogenetic protein (BMP) signaling was required for self-renewal of adult hematopoietic stem cells (HSCs). Through conditional knockout they showed that BMPR-II deficient HSCs have impaired self-renewal and regenerative capacity.
[Haematologica]
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Chromatin Remodeler Znhit1 Preserves Hematopoietic Stem Cell Quiescence by Determining the Accessibility of Distal Enhancers

Investigators found that loss of zinc finger HIT-type containing 1 (Znhit1) led to exhaustion of stem cell pool and impairment of hematopoietic function.
[Leukemia]
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Cell Competition, the Kinetics of Thymopoiesis, and Thymus Cellularity Are Regulated by Double-Negative 2 to 3 Early Thymocytes

The authors aimed to understand the effect of cell competition on thymopoiesis, identify the cells involved, and determine how the process is regulated.
[Cell Reports]
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