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Hematopoiesis News
Hematopoiesis News is an online resource that provides updates on the latest research in the fields of hematopoiesis, blood, and bone marrow disorders.
A Phase I/II Trial of WT1-Specific TCR Gene Therapy for Patients with Acute Myeloid Leukemia and Active Disease Post-Allogeneic Hematopoietic Cell Transplantation: Skewing Towards...
In this Phase I/II clinical trial, scientists evaluated safety, persistence, and efficacy of Epstein-Barr virus- or Cytomegalovirus-specific Wilms Tumor Antigen 1-specific T-cell receptor in...
TNFα Signaling Restores Steady-State Hematopoiesis in a TNFαKO Mouse Model of Anemia of Inflammation.
[Blood] Researchers investigated the role of tumor necrosis factor-α (TNFα) in a mouse model of AI by administering heat-killed Brucella Abortus to germline TNFα knockout mice.
TNFα Signaling Restores Steady-State Hematopoiesis in a TNFαKO Mouse Model of Anemia of Inflammation
[Blood] Researchers investigated the role of tumor necrosis factor-α (TNFα) in a mouse model of anemia of inflammation by administering heat-killed Brucella Abortus to germline TNFα knockout mice.
Repurposing Chlorpromazine for Anti-Leukemic Therapy with the Drug-in-Cyclodextrin-in-Liposome Nanocarrier Platform.
[Carbohydrate Polymers] Investigators demonstrated that drug-in-cyclodextrin-in-liposome (DCL)-based chlorpromazine formulations maintain anti-leukaemic activity, avoid central nervous system accumulation, and allow drug availability adjustments based on the included cyclodextrin.
Clonal Hematopoiesis in Metastatic Urothelial and Renal Cell Carcinoma
[NPJ Precision Oncology] Scientists interrogated clonal hematopoiesis and circulating tumor DNA (ctDNA) in 299 patients with metastatic urothelial or renal cell carcinoma using error-corrected targeted sequencing of matched white blood cell DNA and plasma cfDNA.
BCAS2 Promotes Primitive Hematopoiesis by Sequestering β-Catenin Within the Nucleus.
[eLife] Investigators showed that breast carcinoma amplified sequence 2 (BCAS2) was essential for primitive hematopoiesis in zebrafish and mouse embryos.
Polyamine Depletion Limits Progression of Acute Leukaemia.
[International Journal of Cancer] Scientists investigated the preclinical efficacy of polyamine depletion in acute leukemia. The polyamine biosynthesis inhibitor difluoromethylornithine inhibited the growth of a molecularly diverse panel of acute leukemia cell lines, while non-malignant cells were unaffected.
Conditioning Regimens for Second Allogeneic Hematopoietic Stem Cell Transplantation for Patients with Primary Graft Failure
[Transplantation and Cellular Therapy] Scientists retrospectively analyzed the outcomes of 19 patients with primary graft failure who underwent a second hematopoietic stem cell transplantation between 2017 and 2024.
Inhibition of FLT3-Induced Signalling in Refractory Acute Myeloid Leukemia.
[Bioorganic Chemistry] Researchers followed on the efficacy of five FLT3 inhibitors, two pan-PI3K inhibitors, and two c-KIT inhibitors in order to examine the significance of different signaling cascades in FLT3+-AML.
Targeting Sensitive and Multidrug Resistant Leukemia Cells with a Novel Benzofuran-Isatin Conjugate.
[European Journal of Pharmacology] Scientists highlighted the potential of benzofuran-isatin conjugates to combat multidrug resistance and the role of RND2 for collateral sensitivity.
An Overview on In Vivo Generation of CAR-T Cells Using CRISPR-Loaded Functionalized Nanocarriers for Treating B Cell Lineage Acute Lymphoblastic Leukemia.
[Molecular Biology Reports] The authors describe nanoparticles engineered to specifically target blood circulating T lymphocytes and deliver CRISPR/Cas9 complexes that can integrate chimeric antigen receptor constructs into the TRAC locus and knock out immune checkpoint genes like PD-1 simultaneously.
Investigational Combination of First-in-Class Bispecific Antibodies TALVEY®▼ (Talquetamab) and TECVAYLI®▼ (Teclistamab) Shows Deep and Durable Responses in Heavily Pretreated Multiple Myeloma Patients with Extramedullary...
[Janssen-Cilag International NV] Janssen-Cilag International NV announced new results from the Phase II RedirecTT-1 study evaluating the investigational combination of TALVEY®▼(talquetamab), the first European Commission (EC) approved GPRC5D-directed bispecific antibody, and TECVAYLI®▼(teclistamab), the first EC-approved BCMA-directed bispecific antibody.
Hematopoiesis News curates the top publications and reviews covering the regulation, expression patterns, differentiation and characterization of hematopoietic stem cells, as well as blood and bone marrow disorders. We also feature the latest job postings and upcoming conferences in the hematopoiesis field.
