Foreign Students in US: Trump Administration Drops Deportation Plans

US President Donald Trump’s government has dropped its plans to deport international students whose courses move fully online because of the coronavirus pandemic.
[BBC]
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Journals Endorse New Checklist to Clean Up Sloppy Animal Research

To address the problem of poor reporting, Percie du Sert and a team of researchers have developed a checklist of 10 critical details each animal study needs to report, such as the number of animals used, their sex, whether they were randomly allocated to a test group and control group, and whether the researchers knew which animal was in which group.
[Science Insider]
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FDA Grants Priority Review to Merck’s Supplemental Biologics License Application for KEYTRUDA® (Pembrolizumab) for Second-Line Treatment of Patients with Relapsed or Refractory Classical Hodgkin Lymphoma

Merck announced that the FDA has accepted and granted priority review for a new supplemental Biologics License Application for KEYTRUDA, Merck’s anti-PD-1 therapy, as monotherapy for the treatment of adult patients with relapsed or refractory classical Hodgkin lymphoma.
[Merck & Co., Inc.]
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Endogenous Retroviruses Are a Source of Enhancers with Oncogenic Potential in Acute Myeloid Leukemia

The authors identified six endogenous retrovirus families with acute myeloid leukemia (AML)-associated enhancer chromatin signatures that are enriched in binding of key regulators of hematopoiesis and AML pathogenesis.
[Nature Communications]
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GvHD-Free, Relapse-Free Survival Provides Novel Clues for Optimizing Allogeneic-HSCT for Adult T-Cell Leukemia/Lymphoma

The authors performed a nationwide retrospective study of graft-versus-host disease (GvHD)-free, relapse-free survival of patients with allogeneic hematopoietic stem cell transplantation (HSCT)-treated adult T-cell leukemia/lymphoma.
[Bone Marrow Transplantation]
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Glycogen Accumulation, Central Carbon Metabolism, and Aging of Hematopoietic Stem and Progenitor Cells

Inspired by recent proteomic data demonstrating the upregulation of carbon and glycogen metabolism in aging human hematopoietic stem and progenitor cells, scientists addressed whether this is caused by elevated glycolysis of the hematopoietic stem and progenitor cells on a per cell basis, or by a subpopulation that has become more glycolytic.
[Scientific Reports]
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How Scientific Societies Are Weathering the Pandemic’s Financial Storm

As meetings worldwide have been called off, postponed or moved online because of the pandemic, organizations are trying to weather the cost of cancelling meetings while grappling with the long-term effects that the pandemic could have on their activities and on the research community.
[Nature]
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Signal-Transducing Adapter Protein-1 Is Required for Maintenance of Leukemic Stem Cells in CML

Scientists found that the expression of STAP-1 was aberrantly upregulated in chronic myeloid leukemia (CML) stem cells in patients’ bone marrow.
[Oncogene]
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Which Lower Risk Myelodysplastic Syndromes Should Be Treated with Allogeneic Hematopoietic Stem Cell Transplantation?

The authors review prognostic factors in lower risk MDS, delineating patients with relatively poor risk who may potentially benefit from hematopoietic stem cell transplantation during the disease course.
[Leukemia]
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A 3D Engineered Scaffold for Hematopoietic Progenitor/Stem Cell Co-Culture In Vitro

To imitate the natural microenvironment, a 3D engineered scaffold for CD34+ cells co-culture was established via 3D bioprinting.
[Scientific Reports]
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Immunogenomic Landscape of Hematological Malignancies

Researchers integrated over 8,000 transcriptomes and 2,000 samples with multilevel genomics of hematological cancers to investigate how immunological features are linked to cancer subtypes, genetic and epigenetic alterations, and patient survival, and validated key findings experimentally.
[Cancer Cell]
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