Human Immunology News

Human Immunology News is an online publication and email newsletter for researchers studying the human immune system.

Target Engagement and Immunogenicity of an Active Immunotherapeutic Targeting Pathological α-Synuclein: A Phase 1 Placebo-Controlled Trial

[Nature Medicine] This 44-week, randomized, placebo-controlled, double-blind, single-center Phase I study investigated safety, tolerability and immunogenicity of UB-312, an active immunotherapeutic targeting pathological α-synuclein, in patients with Parkinson's disease.

$18.5 Million U19 Grant Will Study B and T Memory Cells in Transplanted Lungs, Uteruses, and Kidneys

[University of Alabama at Birmingham] A five-year, $18.5 million grant will allow University of Alabama at Birmingham (UAB) researchers to investigate T and B tissue-resident memory cells in transplanted lungs, kidneys and uteruses of UAB patients.

MAIT Cell Activation and Recruitment in Inflammation and Tissue Damage in Acute Appendicitis

Mucosal-associated invariant T (MAIT) cells are antimicrobial T cells abundant in the gut, but mechanisms for their migration into tissues during inflammation are poorly...

Evaluation of Immune Profiles Associated with Control of Mycobacterial Growth in Systemic Lupus Erythematosus (SLE) Patients

[Tuberculosis] Investigators presented a pilot study evaluating intracellular cytokine responses and ex vivo ability to control mycobacterial growth using peripheral blood mononuclear cells collected from systemic lupus erythematosus (SLE) patients before and during SLE treatment.

The Effect of Type 1 Diabetes Protection and Susceptibility Associated HLA Class II Genotypes on DNA Methylation in Immune Cells

[HLA] Researchers examined genome-wide DNA methylation by microarrays to cover over 850,000 CpG sites in the CD4+ T cells and CD19+ B cells of healthy subjects homozygous either for DRB1*15-DQA1*01-DQB1*06:02, associated with a strongly decreased type 1 diabetes (T1D) risk, DRB1*03-DQA1*05-DQB1*02, or DRB1*04:01-DQA1*03-DQB1*03:02, associated with a moderately increased T1D risk.

Duvelisib plus Romidepsin in Relapsed/Refractory T Cell Lymphomas: A Phase Ib/IIa Trial

[Nature Medicine] Researchers conducted a Phase Ib/IIa study of duvelisib in combination with either romidepsin or bortezomib in patients with relapsed/refractory T cell lymphomas and found that the addition of romidepsin, but not bortezomib, appeared to increase efficacy while attenuating PI3K inhibitor-driven toxicity.

Innate Immune Sensing of AAV Vectors

[Human Gene Therapy] Scientists showed that adeno-associated virus (AAV) vectors could initiate several and likely redundant innate immune pathways resulting in an exaggerated adaptive immune response.

DNA of Neutrophil Extracellular Traps Promote NF-κB-Dependent Autoimmunity via cGAS/TLR9 in Chronic Obstructive Pulmonary Disease

[Signal Transduction and Targeted Therapy] Investigators elucidated the immunoregulatory mechanism of neutrophil extracellular traps in chronic obstructive pulmonary disease (COPD), employing human neutrophils, airway epithelial cells, dendritic cells, and a long-term cigarette smoke-induced COPD mouse model.

Synergistic Immunochemotherapy Targeted SAMD4B-APOA2-PD-L1 Axis Potentiates Antitumor Immunity in Hepatocellular Carcinoma

[Cell Death & Disease] Scientists proposed for the first time a synergistic immunochemotherapy that exerted a potent antitumor effect for patients with advanced hepatocellular carcinoma (HCC) in clinical practice based on three common antitumour drugs and found that HCC patients with new synergistic immunochemotherapy had better three-year overall survival than the control group.

Somatic Mutations Associate with Clonal Expansion of CD8+ T Cells

[Science Advances] Investigators examined somatic mutations in CD4+ and CD8+ T cells from 90 patients with hematological and immunological disorders and used T cell receptor and single-cell sequencing to link mutations with T cell expansions and phenotypes.

Schlafen 11 Triggers Innate Immune Responses Through Its Ribonuclease Activity upon Detection of Single-Stranded DNA

[Science Immunology] Scientists reported that intracellular ssDNA triggered cytokine expression and cell death in a CGT motif–dependent manner. They identified Schlafen 11 (SLFN11) as an ssDNA-activated RNase, which was essential for the innate immune responses induced by intracellular ssDNA and adeno-associated virus infection.

Platelets in Kawasaki Disease: Mediators of Vascular Inflammation

[Nature Reviews Rheumatology] The authors review the role of platelets in Kawasaki disease and discuss progress in understanding the immune-effector role of platelets in amplifying inflammation related to Kawasaki disease vasculitis and therapeutic strategies targeting platelets or platelet-derived molecules.

Each issue of Human Immunology News provides up-to-date coverage of the latest news in immunology research performed using human cells or subjects. Our expert editors hand-pick recent research papers and review articles from relevant high-impact peer-reviewed journals on topics including immunotherapy, autoimmunity, adaptive, and innate immunity in humans. We also feature news on clinical trials, award announcements, and funding opportunities.

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