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Human Immunology News
Human Immunology News is an online publication and email newsletter for researchers studying the human immune system.
CXCL12+ Fibroblastic Reticular Cells in Lymph Nodes Facilitate Immune Tolerance by Regulating T Cell-Mediated Alloimmunity
[Journal of Clinical Investigation] Single-cell RNA sequencing of naive and draining lymph nodes (LNs) of heart-transplanted mice and human LNs revealed a specific subset of CXCL12hi fibroblastic reticular cells that expressed high levels of lymphotoxin-β receptor and are enriched in the expression of immunoregulatory genes.
Expansion of Multiple CD4+ T Cell Lineages in Lymphocytic Variant Hypereosinophilic Syndrome
[Journal of Allergy and Clinical Immunology] Investigators delineated the surface phenotypes and cytokine profiles of the aberrant lymphocyte populations in patients with lymphocytic variant hypereosinophilic syndrome.
Sitravatinib Targets TYRO3 to Augment the Anti-Tumor Immune Response of PD-1 Blockade in Hepatocellular Carcinoma
[Clinical Cancer Research] Scientists investigated the anti-tumor efficacy and immunomodulatory activity of sitravatinib in hepatocellular carcinoma.
IGF2BP3-Mediated m6a Modification of RASGRF1 Promoting Joint Injury in Rheumatoid Arthritis
[Bone Research] Investigators collected synovial tissues from normal controls and patients with osteoarthritis or rheumatoid arthritis.
IL-11/IL-11R Signal Inhibition by 9MW3811 Remodels Immune Tumor Microenvironment and Enhances Anti-Tumor Efficacy of PD-1 Blockade
[NPJ Precision Oncology] Scientists introduced 9MW3811, a monoclonal antibody designed to neutralize IL-11 effectively.
MicroRNA Changes with Macro Potential Contribute to Secondary Immunodeficiency in Chronic Lymphocytic Leukemia during Epstein Barr Virus Reactivation
[Scientific Reports] Researchers examined the interplay between miRNA expression profiles, Epstein-Barr virus reactivation, and immune checkpoint pathways in the context of small intestine disease development in chronic lymphocytic leukemia.
PTTG1 Promotes M2 Macrophage Polarization via the cGMP-PKG Signaling Pathway and Facilitates EMT Progression in Human Epithelial Ovarian Cancer Cells
[Discover Oncology] Researchers explored the role of PTTG1 in ovarian cancer via the cGMP-PKG signaling pathway, focusing on its effects on M2 macrophage polarization and EMT progression in epithelial ovarian cancer cells.
Tumor-Infiltrating Immune Cells As a Novel Prognostic Model for Bladder Cancer
[Discover Oncology] Bioinformatics analysis was used to identify differentially expressed genes and tumor-infiltrating immune cells between bladder cancer tissues and adjacent normal tissues.
Interfacial T Cell Engineering
[Nature Reviews Bioengineering] The authors discuss the structural and biochemical features of T cell interfaces at the cell and tissue levels, outlining how these interfaces dictate T cell function and fate.
New Insight into the Role of SOCS Family in Immune Regulation and Autoimmune Pathogenesis
[Journal of Advanced Research] Investigators discuss recent advancements in understanding the complex functions of suppressor of cytokine signaling (SOCS) proteins in various immune cells, as well as the effects of SOCS proteins in human health and diseases.
Mount Sinai Researchers in Semifinals of $101 Million XPRIZE Healthspan, a Competition Seeking Innovative Approaches to Aging Well
[Mount Sinai] Investigators at the Icahn School of Medicine at Mount Sinai have been named semifinalists—and one of the Top 40 Milestone Award winners—in the prestigious XPRIZE Healthspan, a $101 million global competition dedicated to transforming how we age.
Altered T Cell Reactivity in the Early Stages of Alzheimer’S Disease
[Brain] Researchers employed high-dimensional mass cytometry, single-cell RNA-sequencing, ex vivo T cell secretome analysis, and antigen presentation assays to achieve a comprehensive characterization of adaptive immune cell populations.
Each issue of Human Immunology News provides up-to-date coverage of the latest news in immunology research performed using human cells or subjects. Our expert editors hand-pick recent research papers and review articles from relevant high-impact peer-reviewed journals on topics including immunotherapy, autoimmunity, adaptive, and innate immunity in humans. We also feature news on clinical trials, award announcements, and funding opportunities.
