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Human Immunology News
Human Immunology News is an online publication and email newsletter for researchers studying the human immune system.
Tumor-Derived Erythropoietin Acts As an Immunosuppressive Switch in Cancer Immunity
[Science] Using spontaneous preclinical models of hepatocellular carcinoma (HCC) with distinct immunotypes, scientists showed that the EPO/EPOR axis functions as an immunosuppressive switch in macrophages that maintains a T cell–deprived tumor microenvironment, thus posing a major barrier to effective antitumor immunity.
Intensive Lowering of LDL Cholesterol Levels with Evolocumab in Autoimmune or Inflammatory Diseases: An Analysis of the FOURIER Trial
[Circulation] FOURIER was a randomized trial of evolocumab versus placebo in 27 564 patients with stable atherosclerosis who were taking statins. This analysis focused on the effect of evolocumab in patients with or without an autoimmune or inflammatory disease, defined as any autoimmune or chronic inflammatory condition.
Deconvoluting TCR-Dependent and -Independent Activation Is Vital for Reliable Ag-Specific CD4+ T Cell Characterization by AIM Assay
[Science Advances] Researchers showed that CD39+ regulatory T cell (Treg)–like and CD26hi TH22–like cells undergo T cell receptor–independent activation by cytokines during antigen stimulation, leading to nonspecific up-regulation of activation-induced marker readouts.
Repurposing Anti-Viral Subunit and mRNA Vaccines T Cell Immunity for Intratumoral Immunotherapy against Solid Tumors
[NPJ Vaccines] Scientists demonstrated the potential of licensed vaccines as promising platforms for intratumoral immunotherapy, either alone or combined with vaccine- or tumor-derived MHC-I-restricted peptide epitopes.
MARC, a Novel Modular Chimeric Antigen Receptor, Improves T Cell-Based Cancer Immunotherapies by Preventing Early T Cell Exhaustion, and Enhancing Persistence
[Journal of Immunotherapy of Cancer] Investigators developed a modular chimeric antigen receptor leveraging the same assembly principles found in native activating immune receptors to reestablish the intrinsic safeguards in receptor expression and signaling.
Follicular helper- and Peripheral Helper-Like T Cells Drive Autoimmune Disease in Human Immune System Mice
[eLife] Investigators demonstrated that PD-1+CD4+ peripheral helper-like and follicular helper-like T cells developing in human immune system mice could induce autoimmune disease.
A Germline Heterozygous Dominant Negative IKZF2 Variant Causing Syndromic Primary Immune Regulatory Disorder and ICHAD
[Journal of Clinical Immunology] Scientists described the immunological phenotype of one of the first reported cases of germline dominant negative HELIOS deficiency, expands our understanding of the pathogenesis of AIHA on a single cell level, and provides valuable insights into HELIOS function in a variety of lymphocyte subsets.
Efficacy of MET-Targeting CAR T Cells against Glioblastoma Patient-Derived Xenograft Models
[Journal of Translational Medicine] Whereas MET inhibitors are effective in MET-active tumors, MET-CAR T cells eradicate MET-positive glioblastoma (GBM) growth in an antigen-dependent manner, demonstrating a promising therapeutic approach for treating MET-positive GBM.
Vascularized Tumor-on-a-Chip to Investigate Immunosuppression of CAR-T Cells
[Lab On A Chip] Researchers provided mechanistic insight for in vivo observations showing limited CAR-T cell extravasation and effector function in solid tumors.
Solute Carrier Family 15 Member 4, an Emerging Therapeutic Target for Systemic Lupus Erythematosus
[International Reviews of Immunology] The authors summarize recent advances in understanding the role of solute carrier family 15 member 4 (SLC15A4) in disease progression of systemic lupus erythematosus (SLE) and the development of SLC15A4-targeted inhibitors as well as discuss its potential as a target for SLE treatment.
Cullinan Therapeutics to Initiate Study of CLN-978, a Bispecific CD19 T Cell Engager Administered Subcutaneously, in Patients with Sjögren’s Disease in the United States
[Cullinan Therapeutics, Inc.] Cullinan Therapeutics, Inc. announced that the Company is initiating a study of CLN-978 in patients with Sjögren’s disease in the US, they previously received US FDA Investigational New Drug Application clearance to study the CD19 T cell engager in patients with moderate to severe systemic lupus erythematosus and European Medicines Agency approval to study CLN-978 in active, difficult-to-treat rheumatoid arthritis.
Boehringer Ingelheim and Cue Biopharma Partner to Develop Next-Generation Treatment for Autoimmune and Inflammatory Diseases
Boehringer Ingelheim and Cue Biopharma, Inc. announced a strategic research collaboration and license agreement to develop and commercialize Cue Biopharma’s CUE-501 product candidate, a...
Each issue of Human Immunology News provides up-to-date coverage of the latest news in immunology research performed using human cells or subjects. Our expert editors hand-pick recent research papers and review articles from relevant high-impact peer-reviewed journals on topics including immunotherapy, autoimmunity, adaptive, and innate immunity in humans. We also feature news on clinical trials, award announcements, and funding opportunities.
