Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
Human Immunology News
Human Immunology News is an online publication and email newsletter for researchers studying the human immune system.
The Postnatal Injection of AAV9-FOXG1 Rescues Corpus Callosum Agenesis and Other Brain Deficits in the Mouse Model of FOXG1 Syndrome
[Molecular Therapy-Methods & Clinical Development] Scientists explored the therapeutic potential of adeno-associated virus 9 (AAV9) mediated delivery of the FOXG1 gene. Remarkably, intracerebroventricular injection of AAV9-FOXG1 to Foxg1 heterozygous mouse model at the postnatal stage rescues a wide range of brain pathologies.
The Postnatal Injection of AAV9-FOXG1 Rescues Corpus Callosum Agenesis and Other Brain Deficits in the Mouse Model of FOXG1 Syndrome
Scientists explored the therapeutic potential of adeno-associated virus 9 (AAV9) mediated delivery of the FOXG1 gene. Remarkably, intracerebroventricular injection of AAV9-FOXG1 to Foxg1 heterozygous...
Longitudinal Magnetic Resonance Imaging Tracking of Transplanted Neural Progenitor Cells in the Spinal Cord Utilizing the Bright-Ferritin Mechanism
[Stem Cells Translational Medicine] Investigators applied a novel bright-ferritin magnetic resonance imaging mechanism to track human neural progenitor cells (hNPC) transplants longitudinally and on demand in the rat spinal cord. They genetically modified hNPCs to stably overexpress human ferritin.
Efficient Site-Specific Integration of Large Genes in Mammalian Cells via Continuously Evolved Recombinases and Prime Editing
[Nature Biomedical Engineering] The authors showed that phage-assisted continuous evolution enhances prime-editing-assisted site-specific integrase gene editing, which coupled the programmability of prime editing with the ability of recombinases to precisely integrate large DNA cargoes exceeding 10 kilobases.
Metabolic Profiling of CD19+ Cells in Chronic Lymphocytic Leukemia by Single-Cell Mass Spectrometry Imaging
[Clinica Chimica Acta] Investigators developed a single-cell mass spectrometry imaging of human CD19+ lymphocytes and metabolic profiling of chronic lymphocytic leukemia.
The Causal Relationship Between Autoimmune Diseases and Age-Related Macular Degeneration: A Two-Sample Mendelian Randomization Study
[PLOS One] Scientists investigated the potential causal relationship between autoimmune diseases, including systemic lupus erythematosus, rheumatoid arthritis, inflammatory bowel disease, multiple sclerosis, and Type 1 diabetes, and age-related macular degeneration.
A Phase I, Randomized, Double-Blind, Placebo-Controlled, Single- and Multiple-Dose Escalation Study to Evaluate the Safety and Pharmacokinetics/Pharmacodynamics of PF-06835375, a C-X-C Chemokine Receptor Type...
[Arthritis Research & Therapy] Researchers evaluated the safety, tolerability, pharmacokinetics, and pharmacodynamics of PF‑06835375, a potent selective afucosyl immunoglobulin G1 antibody targeting C-X-C chemokine receptor type 5 that potentially depleted B cells, follicular T helper (Tfh) cells, and circulating Tfh-like cells, in patients with systemic lupus erythematosus and rheumatoid arthritis.
Human γδ T Cells in Diverse Tissues Exhibit Site-Specific Maturation Dynamics Across the Life Span
[Science Immunology] Investigators analyzed the phenotype, transcriptome, function, and repertoire of human γδ T cells in blood and mucosal and lymphoid tissues from 176 donors across the life span, revealing distinct profiles in children compared with adults.
High-Throughput Transcriptome Profiling Indicates Ribosomal RNAs to Be Associated with Resistance to Immunotherapy in Non-small Cell Lung Cancer (NSCLC)
[Journal of Immunotherapy of Cancer] Scientists used retrospective cohorts of immune checkpoint inhibitor treated patients with non-small cell lung cancer (NSCLC), to discover and validate spatially resolved protein markers associated with resistance to programmed cell death protein-1 axis inhibition.
Changes in T Cell Subsets Occur in Interstitial Lung Disease and May Contribute to Pathology via Complicated Immune Cascade
[APMIS] The authors investigated the expression profiles of transcription factors, cytokines, and co-stimulatory molecules in helper T-cell subsets within bronchoalveolar lavage samples of patients with interstitial lung diseases.
Comparison of the Effects of Remimazolam Tosylate and Propofol on Immune Function and Hemodynamics in Patients Undergoing Laparoscopic Partial Hepatectomy: A Randomized Controlled Trial
[BMC Anesthesiology] Researchers investigated the differences in immune function and intraoperative hemodynamics between patients who underwent laparoscopic partial hepatectomy with remimazolam tosylate and those who underwent laparoscopic partial hepatectomy with propofol.
SiSaf’s Bio-Courier Technology Enables Clinical Trial Success for Topical Treatment of Mild to Moderate Alopecia Areata
[SiSag, Ltd.] SiSaf, Ltd. announced that a licensee of the ProSilic® variant of its technology has reported positive topline results from a randomized, placebo-controlled, multi-dose Phase II trial evaluating its topical treatment for mild to moderate alopecia areata, commonly known as spot baldness.
Each issue of Human Immunology News provides up-to-date coverage of the latest news in immunology research performed using human cells or subjects. Our expert editors hand-pick recent research papers and review articles from relevant high-impact peer-reviewed journals on topics including immunotherapy, autoimmunity, adaptive, and innate immunity in humans. We also feature news on clinical trials, award announcements, and funding opportunities.
