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Immune Regulation News
Immune Regulation News is an online resource covering research into the regulation, suppression, and modulation of the immune system.
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Unmasking Cancer’s Silent Saboteurs: T Regulatory Cells As Therapeutic Targets in Immunotherapy
[Expert Review of Clinical Immunology] Scientists explore the role of Tregs in the immune system, delve into their contribution to cancer and tumor progression, and highlight therapeutic strategies targeting Tregs, along with innovative delivery systems.
Destruction of VISTA by TRIM25 Ablation in T Cells Potentiates Cancer Immunotherapy
[Cell Research] Researchers unveiled a mechanism for V-domain Ig suppressor of T cell activation (VISTA) regulation in T cells and highlights targeting tripartite motif containing 25 (TRIM25)–VISTA as a potential strategy to enhance tumor immunotherapy.
The IL-1R and NFKBIZ Pathway Mediates Immunoregulatory Responses and Immunotherapy Efficacy in Anaplastic Large Cell Lymphoma
[Leukemia] The authors conducted integrated genome-wide CRISPR-Cas9 loss-of-function screens using CD30-specific CAR-engineered NK cells, alongside a complementary PD-L1 regulator screen, and uncovered a critical role for interleukin-1 receptor signaling in modulating CAR therapy efficacy in both ALK⁺ and ALK⁻ anaplastic large cell lymphoma.
LMO7 Suppresses Tumor-Associated Macrophage Phagocytosis of Tumor Cells through Degradation of LRP1
[Advanced Science] Investigators employed both global and myeloid-specific conditional LIM domain only 7 (LMO7) knockout mice bearing subcutaneous tumors to investigate the role of LMO7 in regulating tumor immunity.
Arthritogenicity of CD11b + Gr1 + Myeloid Cells Is Dependent on Dual Specificity Phosphatase 6 (DUSP6)
[Inflammation Research] Researchers described a new arthritogenic role for dual specificity phosphatase 6 (DUSP6), which is mediated by CD11b+ Gr1 + cells and their glycolytic activity and oxidative burst.
Macrophage Retrotransposon Expression Is Associated with Lupus
[Genes & Immunity] Using the ROS-deficient lupus-prone lpr mouse model, scientists employed bulk RNA sequencing, flow cytometry, and spatially resolved single-cell transcriptome imaging to comprehensively characterize tissue-resident macrophages.
UMC Utrecht Researchers Receive Grant to Develop Predictive Model for Juvenile Dermatomyositis
[UMC Utrecht] A team investigating the pediatric inflammatory disease juvenile dermatomyositis has received a €350,000 grant for the development of a model that more accurately can predict disease progress.
Pathogenic Drivers of Lupus Myocarditis and Potential Therapeutic Targets
[Experimental & Molecular Medicine] The authors offer an overview of the current knowledge on autoreactive T cells and autoantibodies identified in primary systemic lupus erythematosusor autoimmune myocarditis conditions from both clinical and preclinical studies.
Oncogenic KRAS Mutations Drive Immune Suppression through Immune-Related Regulatory Network and Metabolic Reprogramming
[Cell Death & Disease] Scientists review the KRAS mutation-associated immune microenvironment features and discuss how KRAS remodels the immune microenvironment by regulating immune-related molecules, inflammatory factors, and multiple metabolic pathways.
The Role of Coinhibitory Receptor-Expressing Non-T Cells in Inflammation and Immunity: Unsung Heroes or Peripheral Players?
[Experimental & Molecular Medicine] Scientists explore the immune regulatory functions of these coreceptors as expressed on non-conventional T cells, such as myeloid cells and B cells, highlighting their potential contributions to immune regulation.
Local Control of T Cell Fate in Lymph Nodes Safely and Durably Reverses Myelin-Driven Autoimmunity
[Proceedings of the National Academy of Sciences of the United States of America] Investigators delivered diffusion-limited polymer depots to lymph nodes to locally guide T cell fates for the treatment of multiple sclerosis, an autoimmune disease that occurs when the immune system mistakenly attacks myelin.
Nobel Winner’s Team Develops Tech to Make Regulatory T Cells
[The Japan Times] A Japanese research team that includes 2025 Nobel Prize laureate Dr. Shimon Sakaguchi has developed a technique to produce regulatory T cells that suppress excessive immune activity.
For over a decade, Immune Regulation News has been keeping the scientific community up-to-date with the latest research and reviews related to immune regulation. Key research areas covered include the roles of regulatory T cells (Treg cells) in autoimmunity and self-reactivity, as well as immune response to disease, transplantation and cancer. We also provide vital updates on the latest jobs and upcoming events in the field of immunology.
