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Immune Regulation News
Immune Regulation News is an online resource covering research into the regulation, suppression, and modulation of the immune system.
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Revitalizing T Cells: Breakthroughs and Challenges in Overcoming T Cell Exhaustion
[Signal Transduction and Targeted Therapy] The authors provide an overview of the history and milestones in T cell exhaustion research, summarize the mechanisms of T cell exhaustion and its implications in cancer, chronic infections, and autoimmune diseases.
Galectin-3 Exacerbates Autoimmune Diabetes by Limiting Regulatory T Cell Differentiation and Function
[Science Advances] Pharmacological inhibition as well as knockout of Galectin-3 gene both attenuated Galectin-3–mediated suppression of regulatory T cells and protected from insulitis and diabetes onset in nonobese diabetic mice.
IL15/IL15Rα Complex Induces an Antitumor Immune Response Following Radiotherapy Only in the Absence of Tregs and Fails to Expand Progenitor TCF1+ CD8 T Cells
[Molecular Cancer Therapeutics] Researchers showed that the combination of radiotherapy and an IL15/IL15Rα fusion complex failed to confer antitumor efficacy; however, a CD8-driven antitumor immune response can be elicited with the concurrent administration of an aCD25 regulatory T cell–depleting antibody.
Type I and II Interferons Drive Abacavir Hypersensitivity via Treg Suppression and T-Cell Enhancement in Immunocompetent HLA-Transgenic Mice
[Allergy] Scientists highlight the distinct roles of IFN-α and IFN-γ in modulating an immune response against abacavir (APC), with IFN-γ increasing APC activity and IFN-α impairing Treg-mediated regulation in immune competent mice.
Transient Hepatic Reconstitution of Trophic Factors Enhances Aged Immunity
[Nature] Scientists showed that the liver can be transiently repurposed to restore age-diminished immune cues and improve T cell function in aged mice.
Pathogenic Role of IFNγ from Activated CD4+ T Cells in Lupus Model Mice Induced by Topical Treatment with Toll-Like Receptor Agonist Imiquimod
[Clinical and Experimental Immunology] Researchers explored the role of activated CD4⁺ T cells on the pathogenesis of lupus using systemic lupus erythematosus murine models induced by Toll like receptor 7 agonist imiquimod.
Immune Cell Regulation of Zebrafish Heart Regeneration
[Arteriosclerosis Thrombosis and Vascular Biology] The authors review the distinct contributions of neutrophils, macrophages, and lymphoid cells during zebrafish heart regeneration, with a focus on their temporal coordination and regulatory signaling pathways.
Immune Control of Functional Memory CD8 T Cells in Normal-Appearing Vitiligo Skin
[Science Advances] By combining cellular and transcriptomic approaches, researchers showed that common CD8+ T cell clusters with a similar transcriptional profile infiltrate NL and peri-lesional skin of patients with vitiligo.
Opposing Functions of Distinct Regulatory T Cell Subsets in Colorectal Cancer
[Immunity] Investigators examined the heterogeneity of tumoral Treg cells in colorectal cancer and identified two distinct tumoral Treg subsets with differential Il10 expression.
ImmuneWalk Therapeutics Announces Positive Results from Phase I SAD/MAD Study of IW-601, a First-In-Class Therapeutic with Broad Potential in Inflammatory and Autoimmune Diseases
[ImmuneWalk Therapeutics] ImmuneWalk Therapeutics announced positive results from the POINTGUARD study evaluating subcutaneously administered IW-601, a highly selective biologic inhibitor of myeloid cell tissue infiltration. The study met all primary and secondary endpoints, demonstrating safety and tolerability of IW-601 at all doses.
REV-ERB Regulates RORγT+ Regulatory T Cell Specification and Function through the Bhlhe40-C-Maf Axis
[Journal of Experimental Medicine] Scientists reported that transcriptional repressor REV-ERB was critical for the differentiation and function of colonic RORγt+Foxp3+ Treg cells.
Differential Effects of HDAC8 Targeting on Foxp3+ T-Regulatory Cells and Effector T-Cells Promote Anti-Tumor Immunity
[JCI Insight] Scientists demonstrate that knocking down or inhibiting HDAC8 impaired murine Treg suppressive function in vitro and in vivo, but promoted conventional host T cell responses, thereby limiting syngeneic tumor growth.
For over a decade, Immune Regulation News has been keeping the scientific community up-to-date with the latest research and reviews related to immune regulation. Key research areas covered include the roles of regulatory T cells (Treg cells) in autoimmunity and self-reactivity, as well as immune response to disease, transplantation and cancer. We also provide vital updates on the latest jobs and upcoming events in the field of immunology.
