Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
Immune Regulation News
Immune Regulation News is an online resource covering research into the regulation, suppression, and modulation of the immune system.
Subscribe|Follow Us On
Type I and II Interferons Drive Abacavir Hypersensitivity via Treg Suppression and T-Cell Enhancement in Immunocompetent HLA-Transgenic Mice
[Allergy] Scientists highlight the distinct roles of IFN-α and IFN-γ in modulating an immune response against abacavir (APC), with IFN-γ increasing APC activity and IFN-α impairing Treg-mediated regulation in immune competent mice.
Transient Hepatic Reconstitution of Trophic Factors Enhances Aged Immunity
[Nature] Scientists showed that the liver can be transiently repurposed to restore age-diminished immune cues and improve T cell function in aged mice.
Pathogenic Role of IFNγ from Activated CD4+ T Cells in Lupus Model Mice Induced by Topical Treatment with Toll-Like Receptor Agonist Imiquimod
[Clinical and Experimental Immunology] Researchers explored the role of activated CD4⁺ T cells on the pathogenesis of lupus using systemic lupus erythematosus murine models induced by Toll like receptor 7 agonist imiquimod.
Immune Cell Regulation of Zebrafish Heart Regeneration
[Arteriosclerosis Thrombosis and Vascular Biology] The authors review the distinct contributions of neutrophils, macrophages, and lymphoid cells during zebrafish heart regeneration, with a focus on their temporal coordination and regulatory signaling pathways.
Immune Control of Functional Memory CD8 T Cells in Normal-Appearing Vitiligo Skin
[Science Advances] By combining cellular and transcriptomic approaches, researchers showed that common CD8+ T cell clusters with a similar transcriptional profile infiltrate NL and peri-lesional skin of patients with vitiligo.
Opposing Functions of Distinct Regulatory T Cell Subsets in Colorectal Cancer
[Immunity] Investigators examined the heterogeneity of tumoral Treg cells in colorectal cancer and identified two distinct tumoral Treg subsets with differential Il10 expression.
ImmuneWalk Therapeutics Announces Positive Results from Phase I SAD/MAD Study of IW-601, a First-In-Class Therapeutic with Broad Potential in Inflammatory and Autoimmune Diseases
[ImmuneWalk Therapeutics] ImmuneWalk Therapeutics announced positive results from the POINTGUARD study evaluating subcutaneously administered IW-601, a highly selective biologic inhibitor of myeloid cell tissue infiltration. The study met all primary and secondary endpoints, demonstrating safety and tolerability of IW-601 at all doses.
REV-ERB Regulates RORγT+ Regulatory T Cell Specification and Function through the Bhlhe40-C-Maf Axis
[Journal of Experimental Medicine] Scientists reported that transcriptional repressor REV-ERB was critical for the differentiation and function of colonic RORγt+Foxp3+ Treg cells.
Differential Effects of HDAC8 Targeting on Foxp3+ T-Regulatory Cells and Effector T-Cells Promote Anti-Tumor Immunity
[JCI Insight] Scientists demonstrate that knocking down or inhibiting HDAC8 impaired murine Treg suppressive function in vitro and in vivo, but promoted conventional host T cell responses, thereby limiting syngeneic tumor growth.
CD8+ Regulatory T Cells
[Annual Review of Immunology] Although the contribution of CD4+ Tregs to self-tolerance has been extensively studied, less attention has been given to CD8+ Tregs. Scientists review recent insights into the development, function, and potential clinical applications of this regulatory subset.
In Vivo CRISPR Screen Reveals Regulation of Macrophage States in Neuroinflammation
[Nature Neuroscience] The authors established an in vivo CRISPR screening pipeline using genetically editable progenitor cells to dissect macrophage regulation in mouse models of multiple sclerosis.
Sequential lymphotoxin-β Receptor and Retinoic Acid Receptor Signals Regulate cDC2 Fate
[Nature Immunology] Investigators established the developmental and transcriptional relationships between diverse type 2 conventional dendritic cell subsets and identified signals that regulate their prevalence in specific lymphoid tissues.
For over a decade, Immune Regulation News has been keeping the scientific community up-to-date with the latest research and reviews related to immune regulation. Key research areas covered include the roles of regulatory T cells (Treg cells) in autoimmunity and self-reactivity, as well as immune response to disease, transplantation and cancer. We also provide vital updates on the latest jobs and upcoming events in the field of immunology.
