Immune Regulation News

Immune Regulation News is an online resource covering research into the regulation, suppression, and modulation of the immune system.

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CCR8 Expression on Regulatory T Cells Reveals Trajectories of Tissue Adaptation and Protects against Myocardial Infarction-Induced Tissue Damage

February 13, 2026

[Circulation] Investigators used single-cell and bulk RNA sequencing in a murine myocardial infarction model to delineate the differentiation trajectory of Tregs from mediastinal lymph nodes to the heart.

Integrin αVβ8-Mediated TGF-β1 Activation Regulates the Sustained Response in Immune Thrombocytopenia after TPO-RA Withdrawal

February 13, 2026

[Blood] Scientists used TGF-β1 conditional knockout mice to specifically target platelets and megakaryocytes in a passive ITP model.

Selective SIK2/SIK3 Inhibition Reprograms Pro- and Antiinflammatory Pathways in Myeloid Cells, Improving Autoimmune Disease Outcomes

February 13, 2026

[JCI Insight] Preclinical studies in mouse models of colitis, psoriasis, and arthritis demonstrated that SIK2/SIK3 inhibition reduced inflammatory activity and promoted immunoregulatory and tolerogenic-associated pathways.

Treg-γδ T Cell Axis Determines Sexual Dimorphism in Hepatocarcinogenesis

February 12, 2026

[Nature Communications] Scientists revealed significant sexual dimorphism in Tregs. Compared with hepatocellular carcinoma in female mice/patients, tumors in male mice/patients are more enriched in Tregs.

SAICAR Drives T Regulatory Cell Differentiation and FOXP3 Maintenance to Promote Immunotherapy Resistance

February 12, 2026

[Cancer Research] Investigators identified the purine biosynthesis intermediate succinylaminoimidazole carboxamide ribose-5′-phosphate (SAICAR) as a key metabolic driver of Treg induction and resistance to anti–PD-1 immunotherapy.

The Distinct Roles of ROS in Tumor Immunity: From Mechanisms to Immunotherapeutic Applications

February 12, 2026

[Journal of Hematology & Oncology] Scientists highlight the differential redox sensitivities between tumor cells and key immune subsets. This differential sensitivity, where cytotoxic T cells are exhausted and immunosuppressive cells like Tregs thrive, is a fundamental mechanism of immune evasion.

Ulcerative Colitis: Signaling Pathways, Therapeutic Targets, and Interventional Strategies

February 12, 2026

[Signal Transduction and Targeted Therapy] The authors discuss several cellular processes, such as autophagy, endoplasmic reticulum stress, mitochondrial dysfunction, macrophage polarization, ferroptosis and the Th/Treg cell balance, which are associated with the occurrence and development of Ulceralive Colitis.

Kincell Bio Announces Partnership with RegCell to Advance Treg Cell Therapies into Clinical Trials for Autoimmune Diseases

February 11, 2026

[Kincell Bio] Kincell Bio announced a new collaboration with RegCell, a biotechnology company developing first‑in‑class immune tolerance platform based on epigenetically reprogrammed regulatory T cells.

CAR-Mediated Release of IL-10 Increases the Function of Regulatory T Cells: Relevance for Future Clinical Application

February 6, 2026

[Molecular Therapy] Researchers used their HLA-A*02 CAR and immunosuppressive IL-10 as model components to generate human CAR-Tregs that release IL-10 upon CAR-engagement.

MSCs-Derived CRABP2 Regulates Treg/CXCL1 to Ameliorate Alcohol-Induced Liver Injury

February 5, 2026

[Cell Communication and Signaling] Researchers performed MSC infusion on an animal model of acute-on-chronic alcohol-induced liver injury. MSC therapy ameliorated liver damage, and elevated the proportion of Tregs by secreting cellular retinoic acid binding protein 2 (CRABP2).

From Pathogenesis to Therapy: The Emerging Role of Regulatory T Cells in Amyotrophic Lateral Sclerosis

February 5, 2026

[Journal of Neuroinflammation] The authors summarize recent advances in understanding Treg biology in amyotrophic lateral sclerosis, including their dynamic alterations across different disease stages and their potential immunoregulatory mechanisms

Tr1X Presents First Clinical Data Demonstrating Proof of Safety and Proof of Mechanism With Allogeneic Off-the-Shelf Tr1 Regulatory T Cell Therapy TRX103

February 4, 2026

[Tr1X (Businesswire)] Tr1X announced the first clinical data from its ongoing Phase I study of TRX103 in patients with hematologic malignancies undergoing HLA-mismatched hematopoietic peripheral stem cell transplantation.

For over a decade, Immune Regulation News has been keeping the scientific community up-to-date with the latest research and reviews related to immune regulation. Key research areas covered include the roles of regulatory T cells (Treg cells) in autoimmunity and self-reactivity, as well as immune response to disease, transplantation and cancer. We also provide vital updates on the latest jobs and upcoming events in the field of immunology.