Immune Regulation News

Immune Regulation News is an online resource covering research into the regulation, suppression, and modulation of the immune system.

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Pyroptosis Modulates Multiple Immune Cell Populations in Targeted Therapy-Treated Melanoma

November 28, 2025

[Cancer Immunology Research] Using single-cell RNA-sequencing and flow cytometry in BRAFi + MEKi treated melanoma, researchers showed herein that isogenic Gsdme knockout tumors show decreased infiltration with T cells, natural killer cells, and regulatory T cells compared to control tumors.

The Frequency of Regulatory T-Cells in Hashimoto’s Thyroiditis and Graves’ Disease

November 28, 2025

[Clinical and Experimental Medicine] Investigators compared the number of CD4/CD25/FOXP3 T regulatory cells in the different forms of autoimmune thyroid diseases and in the normal population.

Cellular Immune Endophenotypes Separating Early and Late-Onset Myasthenia Gravis

November 28, 2025

[JCI Insight] Analyzing two independent cohorts,researchers identified distinct immunological differences driven by three main lymphocyte populations. Lower frequencies of mucosa-associated invariant T cells and naïve CD8 T cells were observed in late-onset myasthenia, suggesting enhanced immune senescence.

Caspase-3 Deficiency Inhibits the Development and Anti-Tumor Response of Bone Marrow-Derived Dendritic Cells

November 28, 2025

[Discover Oncology] Scientists investigated the impact of Caspase-3 gene deletion on bone marrow-derived dendritic cells (BMDCs) and their anti-tumor functions. BMDCs were generated in vitro using GM-CSF and IL-4 from Caspase-3 knockout and heterozygous mouse progenitors.

Macrophage-Derived Exosomes in Autoimmune Diseases: Mechanistic Insights and Therapeutic Implications

November 28, 2025

[Immunologic Research] The authors compile current evidence regarding the involvement of macrophage-derived exosomes in autoimmune disorders such as rheumatoid arthritis and systemic lupus erythematosus, emphasizing their potential as both biomarkers and therapeutic agents.

Imfinzi Approved in the US As First and Only Perioperative Immunotherapy for Patients with Early Gastric and Gastroesophageal Cancers

November 28, 2025

[Astrazeneca] AstraZeneca’s Imfinzi in combination with standard-of-care fluorouracil, leucovorin, oxaliplatin, and docetaxel chemotherapy has been approved in the US for the treatment of adult patients with resectable, early-stage and locally advanced gastric and gastroesophageal junction cancers.

Lysosomal Acidity and Cathepsin L Activate Eosinophils via ARG1-Mediated Arginine Metabolism in Allergic Airway Inflammation

November 25, 2025

[Nature Communications] Scientists demonstrated that lysosomal acidity and cathepsin L activity in eosinophils are elevated in asthmatic patients and mouse models.

Antigen-Specific B Cell Response Regulation by IL-10-Producing Tolerogenic Dendritic Cells

November 25, 2025

[Science Advances] Researchers showed that IL-10–producing tolerogenic dendritic cells regulate B cell responses through direct and indirect mechanisms.

Glycolysis Inhibition Functionally Reprograms T Follicular Helper Cells and Reverses Lupus

November 25, 2025

[Cell Reports] Scientists investigated the mechanisms by which the glycolysis inhibitor 2-deoxy-d-glucose reduces the expansion of T follicular helper cells and the associated production of autoantibodies in lupus-prone mice.

Collaborative Research Center on Novel Cancer Therapies Extended

November 25, 2025

[University of Freiburg] The German Research Foundation announced that it would fund the existing Collaborative Research Centre (CRC) 1479 ‘Oncogene-driven immune escape (OncoEscape)‘ at the University of Freiburg for a further funding period of three and a half years.

GPR25 Promotes the Formation of Lung and Liver Tissue-Resident Memory CD8 T Cells

November 25, 2025

[Science Immunology] Using adoptive transfer, the authors found that Gpr25-deficient T cells infiltrated tissues normally after viral infection but failed to efficiently develop into tissue-resident memory CD8 T cells.

A Selective RPL15 PROTAC Degrader Enhances Anti-PD-1 Immunotherapy in a Murine Melanoma Tumor Model

November 24, 2025

[Oncogene] The authors synthesized SN-38-conjugated pomalidomide (SN38-PROTAC) and showed that SN38-PROTAC induced ubiquitin-mediated degradation of RPL15, but not topoisomerase I.

For over a decade, Immune Regulation News has been keeping the scientific community up-to-date with the latest research and reviews related to immune regulation. Key research areas covered include the roles of regulatory T cells (Treg cells) in autoimmunity and self-reactivity, as well as immune response to disease, transplantation and cancer. We also provide vital updates on the latest jobs and upcoming events in the field of immunology.