Immune Regulation News

Immune Regulation News is an online resource covering research into the regulation, suppression, and modulation of the immune system.

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Butyrophilin 2A2 Promotes T Cell Immunoregulation via CD45 Phosphatase Activation and Protects against Murine Autoimmune Glomerulonephritis and Pregnancy Loss

January 9, 2026

[Nature Communications] The authors identified buytyrophilin 2A2 (BTN2A2) as a modulator of CD45RO signaling in T cells, providing insight into how BTN2A2 regulates T cell-dependent immune responses including those mediating autoimmunity and transplant rejection.

CCL5 Deficiency Aggravates Acute DSS-Induced Colitis by Restricting IL-33-Induced Formation of Tregs in Intestinal Tract

January 8, 2026

[Clinical Science] Resarchers investigate chemokine ligand 5 (CCL5) as a critical immune modulator in Ulceralive Colitis, focusing on its effects on immune cell activation, particularly regulatory T cell formation, and the molecular pathways involved in these processes.

Altered Thymopoiesis in Thymoma Is Associated with Defects in Negative Selection Machinery and Decreased Treg Abundance

January 8, 2026

[Cancer Immunology Research] Investigators performed a phenotypic, single-cell RNA sequencing and spatial analysis of both the T cells and tumoral cells. T cells at all stages of T-cell development—from immature to mature—were present in the tumor, suggesting active thymopoiesis in thymoma.

Revitalizing T Cells: Breakthroughs and Challenges in Overcoming T Cell Exhaustion

January 7, 2026

[Signal Transduction and Targeted Therapy] The authors provide an overview of the history and milestones in T cell exhaustion research, summarize the mechanisms of T cell exhaustion and its implications in cancer, chronic infections, and autoimmune diseases.

Galectin-3 Exacerbates Autoimmune Diabetes by Limiting Regulatory T Cell Differentiation and Function

January 6, 2026

[Science Advances] Pharmacological inhibition as well as knockout of Galectin-3 gene both attenuated Galectin-3–mediated suppression of regulatory T cells and protected from insulitis and diabetes onset in nonobese diabetic mice.

IL15/IL15Rα Complex Induces an Antitumor Immune Response Following Radiotherapy Only in the Absence of Tregs and Fails to Expand Progenitor TCF1+ CD8 T Cells

January 6, 2026

[Molecular Cancer Therapeutics] Researchers showed that the combination of radiotherapy and an IL15/IL15Rα fusion complex failed to confer antitumor efficacy; however, a CD8-driven antitumor immune response can be elicited with the concurrent administration of an aCD25 regulatory T cell–depleting antibody.

Type I and II Interferons Drive Abacavir Hypersensitivity via Treg Suppression and T-Cell Enhancement in Immunocompetent HLA-Transgenic Mice

December 22, 2025

[Allergy] Scientists highlight the distinct roles of IFN-α and IFN-γ in modulating an immune response against abacavir (APC), with IFN-γ increasing APC activity and IFN-α impairing Treg-mediated regulation in immune competent mice.

Transient Hepatic Reconstitution of Trophic Factors Enhances Aged Immunity

December 19, 2025

[Nature] Scientists showed that the liver can be transiently repurposed to restore age-diminished immune cues and improve T cell function in aged mice.

Pathogenic Role of IFNγ from Activated CD4+ T Cells in Lupus Model Mice Induced by Topical Treatment with Toll-Like Receptor Agonist Imiquimod

December 19, 2025

[Clinical and Experimental Immunology] Researchers explored the role of activated CD4⁺ T cells on the pathogenesis of lupus using systemic lupus erythematosus murine models induced by Toll like receptor 7 agonist imiquimod.

Immune Cell Regulation of Zebrafish Heart Regeneration

December 19, 2025

[Arteriosclerosis Thrombosis and Vascular Biology] The authors review the distinct contributions of neutrophils, macrophages, and lymphoid cells during zebrafish heart regeneration, with a focus on their temporal coordination and regulatory signaling pathways.

Immune Control of Functional Memory CD8 T Cells in Normal-Appearing Vitiligo Skin

December 16, 2025

[Science Advances] By combining cellular and transcriptomic approaches, researchers showed that common CD8+ T cell clusters with a similar transcriptional profile infiltrate NL and peri-lesional skin of patients with vitiligo.

Opposing Functions of Distinct Regulatory T Cell Subsets in Colorectal Cancer

December 16, 2025

[Immunity] Investigators examined the heterogeneity of tumoral Treg cells in colorectal cancer and identified two distinct tumoral Treg subsets with differential Il10 expression.

For over a decade, Immune Regulation News has been keeping the scientific community up-to-date with the latest research and reviews related to immune regulation. Key research areas covered include the roles of regulatory T cells (Treg cells) in autoimmunity and self-reactivity, as well as immune response to disease, transplantation and cancer. We also provide vital updates on the latest jobs and upcoming events in the field of immunology.