Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
Immune Regulation News
Immune Regulation News is an online resource covering research into the regulation, suppression, and modulation of the immune system.
Subscribe|Follow Us On
ImmuneWalk Therapeutics Announces Positive Results from Phase I SAD/MAD Study of IW-601, a First-In-Class Therapeutic with Broad Potential in Inflammatory and Autoimmune Diseases
[ImmuneWalk Therapeutics] ImmuneWalk Therapeutics announced positive results from the POINTGUARD study evaluating subcutaneously administered IW-601, a highly selective biologic inhibitor of myeloid cell tissue infiltration. The study met all primary and secondary endpoints, demonstrating safety and tolerability of IW-601 at all doses.
REV-ERB Regulates RORγT+ Regulatory T Cell Specification and Function through the Bhlhe40-C-Maf Axis
[Journal of Experimental Medicine] Scientists reported that transcriptional repressor REV-ERB was critical for the differentiation and function of colonic RORγt+Foxp3+ Treg cells.
Differential Effects of HDAC8 Targeting on Foxp3+ T-Regulatory Cells and Effector T-Cells Promote Anti-Tumor Immunity
[JCI Insight] Scientists demonstrate that knocking down or inhibiting HDAC8 impaired murine Treg suppressive function in vitro and in vivo, but promoted conventional host T cell responses, thereby limiting syngeneic tumor growth.
CD8+ Regulatory T Cells
[Annual Review of Immunology] Although the contribution of CD4+ Tregs to self-tolerance has been extensively studied, less attention has been given to CD8+ Tregs. Scientists review recent insights into the development, function, and potential clinical applications of this regulatory subset.
In Vivo CRISPR Screen Reveals Regulation of Macrophage States in Neuroinflammation
[Nature Neuroscience] The authors established an in vivo CRISPR screening pipeline using genetically editable progenitor cells to dissect macrophage regulation in mouse models of multiple sclerosis.
Sequential lymphotoxin-β Receptor and Retinoic Acid Receptor Signals Regulate cDC2 Fate
[Nature Immunology] Investigators established the developmental and transcriptional relationships between diverse type 2 conventional dendritic cell subsets and identified signals that regulate their prevalence in specific lymphoid tissues.
Leukemia Escapes Immunity by Imposing a Type 1 Regulatory Program on Neoantigen-Specific CD4+ T Cells
[Blood] Using clinical a novel mouse model, researchers showed that neoantigen-specific CD4+ T cells are induced to adopt type 1 regulatory (Tr1) function in the leukemia microenvironment.
Prostaglandin E-EP2/EP4 Signaling Induces the Tumor-Infiltrating Treg Phenotype for Tumor Growth
[Proceedings of the National Academy of Sciences of the United States of America] Investigators showed that prostaglandin E2 (PGE2) produced in tumor microenvironment directly acts on its receptor EP2/EP4 on Tregs to induce the tumor-infiltrating Treg phenotype.
Immunomodulation of UVB-Induced Regulatory T Cells Prevents the Establishment of Squamous Cell Carcinoma
[Journal for Immunotherapy of Cancer] Scientists showed that the manipulation of ultraviolet-induced regulatory T cells prevents early cutaneous squamous cell carcinoma establishment.
A “Function-First” Approach to Identify Regulatory T Cell-Targeting Antibodies for Immunotherapy
[Cancer Immunology Research] To generate antibodies specific for tumor-associated Tregs, lymphocytes were isolated from tumor-bearing mice and panned against the n-CoDeR phage antibody library.
Pyroptosis Modulates Multiple Immune Cell Populations in Targeted Therapy-Treated Melanoma
[Cancer Immunology Research] Using single-cell RNA-sequencing and flow cytometry in BRAFi + MEKi treated melanoma, researchers showed herein that isogenic Gsdme knockout tumors show decreased infiltration with T cells, natural killer cells, and regulatory T cells compared to control tumors.
The Frequency of Regulatory T-Cells in Hashimoto’s Thyroiditis and Graves’ Disease
[Clinical and Experimental Medicine] Investigators compared the number of CD4/CD25/FOXP3 T regulatory cells in the different forms of autoimmune thyroid diseases and in the normal population.
For over a decade, Immune Regulation News has been keeping the scientific community up-to-date with the latest research and reviews related to immune regulation. Key research areas covered include the roles of regulatory T cells (Treg cells) in autoimmunity and self-reactivity, as well as immune response to disease, transplantation and cancer. We also provide vital updates on the latest jobs and upcoming events in the field of immunology.
