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Immune Regulation News
Immune Regulation News is an online resource covering research into the regulation, suppression, and modulation of the immune system.
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Regulation of Allergies across the Body by Microbial Metabolites
[Experimental & Molecular Medicine] Microbial metabolites, such as short-chain fatty acids, indole metabolites and bile acids, can exert specific regulatory effects on the various components of the immune system, such as barrier epithelial cells and immune cells, including dendritic cells, macrophages, T cells, B cells, innate lymphoid cells, and mast cells.
Intratumoral Parvimonas Micra Promotes Esophageal Squamous Cell Carcinoma via P-Cresol-Induced Treg Differentiation
[Science Advances] Investigators demonstrated that Parvimonas micra promotes tumor growth by secreting p-cresol, a metabolite of amino acid fermentation, which elevates reactive oxygen species levels and induces FOXP3+ Treg differentiation, thereby fostering immunosuppression and tumor growth.
The Crohn’s Disease-Related RNF123 Prevents NLRP3 Inflammasome Assembly by Catalyzing Unanchored K63-Linked Ubiquitination on NEK7
[Proceedings of The National Academy of Sciences of The United States of America] Scientists established RNF123 as a regulator for the NLRP3 inflammasome, highlighting its implication in the NLRP3 inflammasome-driven inflammatory diseases.
Peripheral Immune-Inducer Dendritic Cells Drive Early-Life Allergic Inflammation
[Nature] Investigators found that in early life, exposure to common allergens triggers a distinct bifurcated immune response, simultaneously triggering type 17 inflammation in the skin and initiating canonical T helper 2 sensitization in the lymph nodes.
TGF-β Signaling Mediates Crosstalk Between CD8 T Cells and CD39 Induced Treg Cells in Autoimmune Inflammation
[Journal of Biomedical Science] Researchers investigated the role of CD8+ T cells in regulating induced Tregs using in vitro T cell co-culture assays and two in vivo models of autoimmune disease.
Specific Depletion of TIGIT CD226 Clonally Expanded Intratumoral Tregs Defines Safe and Effective TIGIT Targeting
[Journal for Immunotherapy of Cancer] Using mouse models and clinical sample analysis, scientists identified a population of T cell immunoglobulin and ITIM domain (TIGIT)high CD226− clonally expanded intratumoral Tregs as a major barrier limiting the ability of TIGIT blockade to enhance effector cell function.
Serglycin Drives LAG3+ Treg Differentiation and Immunosuppression in Gastric Cancer
[Cancer Research] Analysis of an integrated single-cell RNA-sequencing dataset of 23 paired gastric cancer tissues and adjacent normal gastric mucosa tissues revealed that Tregs were enriched in the gastric cancer tissues and associated with serglycin levels.
Cue Biopharma Announces Preclinical Safety and Tolerability Data for CUE-401 for the Treatment of Autoimmune and Inflammatory Diseases
[Cue Biopharma, Inc.] Cue Biopharma, Inc. announced preclinical safety and tolerability data that further supports the preclinical profile of CUE-401, which is designed to promote immune regulation and tolerance.
Nektar Therapeutics Announces Research Collaboration with UCSF and Dr. Stephen Hauser for NKTR-0165, a Tumor Necrosis Factor Receptor 2 (TNFR2) Antibody, in Multiple Sclerosis
[Nektar Therapeutics] Nektar Therapeutics announced an academic research collaboration with the University of California, San Francisco and Dr. Stephen Hauser. Dr. Hauser is neuroimmunologist whose research work has played a pivotal role in transforming the treatment landscape for patients with multiple sclerosis.
Transcription Factor Etv3 Controls the Tolerogenic Function of Dendritic Cells
[Science] Investigators reported that transcription factor Etv3 was preferentially expressed in mature dendritic cells (DCs), including tissue-derived migratory DCs, and facilitates their homeostatic maturation and CCR7-dependent migration.
RORγT+ APCs Require a Distinct Cis-Regulatory Element to Instruct Tolerance to Dietary Antigens
[Nature Communications] The authors identified a cis transcriptional regulatory element that distinguishes RORγt+ antigen-presenting cells from other of RORγt+ cell types.
Regulatory T Cells Safeguard Liver Health during Metabolic-Associated Steatohepatitis
[Proceedings of the National Academy of Sciences of the United States of America] Multipronged data on a complementary pair of murine metabolic-dysfunction-associated steatohepatitis (MASH) models and published single-cell RNA-sequencing datasets from MASH patients revealed a critical protective role for Foxp3+CD4+ Tregs in MASH.
For over a decade, Immune Regulation News has been keeping the scientific community up-to-date with the latest research and reviews related to immune regulation. Key research areas covered include the roles of regulatory T cells (Treg cells) in autoimmunity and self-reactivity, as well as immune response to disease, transplantation and cancer. We also provide vital updates on the latest jobs and upcoming events in the field of immunology.
