Chinchilla Supplier Loses License over Animal Welfare Violations

Moulton Chinchilla Ranch, the main US source of the animals for research, had a years-long history of disturbing findings in USDA inspections.
[The Scientist LLC]
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Genome-Wide Associations for Immune Traits in Two Maternal Pig Lines

The objective of this study was to identify genomic regions with a biological relevance for the immunocompetence of piglets. Genome-wide Association Studies in 535 Landrace and 461 Large White piglets were performed, investigating 20 immune relevant traits.
[BMC Genomics]
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Niraparib Exhibits a Synergistic Anti-Tumor Effect with PD-L1 Blockade by Inducing an Immune Response in Ovarian Cancer

Programmed death ligand 1 (PD-L1) expression in human ovarian cancer cells after PARP inhibitors treatment was examined by western blotting and flow cytometry.
[Journal of Translational Medicine]
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Intrauterine Administration of Peripheral Blood Mononuclear Cells (PBMCs) Improves Embryo Implantation in Mice by Regulating Local Treg/Th17 Cell Balance

Investigators determined the effect of intrauterine administration of mouse PBMCs prior to embryo implantation on endometrial receptivity and embryo implantation, and examined the underlying mechanism of Treg/Th17 cell balance following intrauterine administration of PBMCs.
[Journal of Reproduction and Development]
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Biomaterial-Enabled Induction of Pancreatic-Specific Regulatory T Cells through Distinct Signal Transduction Pathways

Scientists used poly (lactic-co-glycolide) to co-encapsulate type 1 diabetes-relevant antigen and 3 distinct TREG-inducing molecules – rapamycin, all-trans retinoic acid, and butyrate – that targeted the mechanistic target of Rapa, the retinoid pathway, and histone deacetylase inhibition, respectively.
[Drug Delivery and Translational Research]
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Fermented Food Tempeh Induces Interleukin 12 and Enhances Macrophage Phagocytosis

Researchers investigated the IL-12 inducibility of fermented foods using the specific antibody. Fermented soybean foods such as Tempeh and Natto are attracting attention in terms of nutrition, functionality, and food problems.
[Journal of Food Biochemistry]
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Immunoregulation by Type I Interferons in the Peritoneal Cavity

The authors provide an overview of the major immune cell populations that reside in the peritoneal cavity and highlight their contribution to the initiation, progression, or resolution of peritoneal diseases.
[Journal of Leukocyte Biology]
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Tubular Lysosomes Harbor Active Ion Gradients and Poise Macrophages for Phagocytosis

Investigators described a DNA-based assembly that tubulated lysosomes in macrophages without activating them. Proteolytic activity maps at single-lysosome resolution revealed that tubular lysosomes were less degradative and showed proximal to distal luminal pH and Ca2+ gradients.
[Proceedings of the National Academy of Sciences of the United States of America]
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Understanding Human Mast Cells: Lesson from Therapies for Allergic and Non-Allergic Diseases

Scientists discuss the existing and emerging therapies that target mast cells, and they consider how these treatments can help us to understand mast cell functions in disease.
[Nature Reviews Immunology]
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Attenuation of Apoptotic Cell Detection Triggers Thymic Regeneration after Damage

The authors demonstrated a trigger of thymic regeneration, centered on detecting the loss of dying thymocytes that were abundant during steady-state T cell development.
[Cell Reports]
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Inhibition of the BTK-IDO-mTOR Axis Promotes Differentiation of Monocyte-Lineage Dendritic Cells and Enhances Anti-Tumor T Cell Immunity

Researchers examined how targeting pathways that inhibit the differentiation of inflammatory myeloid cells affect antitumor immunity.
[Immunity]
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