USP15: A Review of Its Implication in Immune and Inflammatory Processes and Tumor Progression

reviewed are recent studies of USP15 in model cell lines in vitro, and in mutant mice in vivo with reference to available human clinical datasets.
[Genes & Immunity]
Georges, A., Gros, P., & Fodil, N. (2021). USP15: a review of its implication in immune and inflammatory processes and tumor progression. Genes & Immunity, 1–12. https://doi.org/10.1038/s41435-021-00125-9 Cite
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Cellular and Molecular Mechanisms Breaking Immune Tolerance in Inborn Errors of Immunity

Scientists demonstrated that ZIP8 was specifically upregulated in CD4+ T cells that infiltrated the inflamed joint and that ZIP8 deficiency in CD4+ T cells abrogated collagen-induced arthritis.
[Experimental & Molecular Medicine]
Sogkas, G., Atschekzei, F., Adriawan, I. R., Dubrowinskaja, N., Witte, T., & Schmidt, R. E. (2021). Cellular and molecular mechanisms breaking immune tolerance in inborn errors of immunity. Cellular & Molecular Immunology, 1–19. https://doi.org/10.1038/s41423-020-00626-z Cite
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Monocyte Progenitors Give Rise to Multinucleated Giant Cells

Researchers showed that the giant cell-forming potential is a particular trait of monocyte progenitors.
[Nature Communications]
Lösslein, A. K., Lohrmann, F., Scheuermann, L., Gharun, K., Neuber, J., Kolter, J., Forde, A. J., Kleimeyer, C., Poh, Y. Y., Mack, M., Triantafyllopoulou, A., Dunlap, M. D., Khader, S. A., Seidl, M., Hölscher, A., Hölscher, C., Guan, X. L., Dorhoi, A., & Henneke, P. (2021). Monocyte progenitors give rise to multinucleated giant cells. Nature Communications, 12(1), 2027. https://doi.org/10.1038/s41467-021-22103-5 Cite
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Processed Foods Drive Intestinal Barrier Permeability and Microvascular Diseases

Investigators showed in rodent models that long-term consumption of a processed diet drives intestinal barrier permeability and an increased risk of chronic kidney disease.
[Science Advances]
Snelson, M., Tan, S. M., Clarke, R. E., Pasquale, C. de, Thallas-Bonke, V., Nguyen, T.-V., Penfold, S. A., Harcourt, B. E., Sourris, K. C., Lindblom, R. S., Ziemann, M., Steer, D., El-Osta, A., Davies, M. J., Donnellan, L., Deo, P., Kellow, N. J., Cooper, M. E., Woodruff, T. M., … Coughlan, M. T. (2021). Processed foods drive intestinal barrier permeability and microvascular diseases. Science Advances, 7(14), eabe4841. https://doi.org/10.1126/sciadv.abe4841 Cite
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TAP Dysfunction in Dendritic Cells Enables Noncanonical Cross-Presentation for T Cell Priming

Scientists found that protective CD8+ T cells could be mobilized during viral infection even when TAP was absent in all hematopoietic cells.
[Nature Immunology]
Barbet, G., Nair-Gupta, P., Schotsaert, M., Yeung, S. T., Moretti, J., Seyffer, F., Metreveli, G., Gardner, T., Choi, A., Tortorella, D., Tampé, R., Khanna, K. M., García-Sastre, A., & Blander, J. M. (2021). TAP dysfunction in dendritic cells enables noncanonical cross-presentation for T cell priming. Nature Immunology, 1–13. https://doi.org/10.1038/s41590-021-00903-7 Cite
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Reprogramming Lipid Metabolism Prevents Effector T Cell Senescence and Enhances Tumor Immunotherapy

Researchers report that development of T cell senescence driven by both malignant tumor cells and regulatory T cells is a general feature in cancers
[Science Translational Medicine]
Liu, X., Hartman, C. L., Li, L., Albert, C. J., Si, F., Gao, A., Huang, L., Zhao, Y., Lin, W., Hsueh, E. C., Shen, L., Shao, Q., Hoft, D. F., Ford, D. A., & Peng, G. (2021). Reprogramming lipid metabolism prevents effector T cell senescence and enhances tumor immunotherapy. Science Translational Medicine, 13(587). https://doi.org/10.1126/scitranslmed.aaz6314 Cite
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Macrophages in Microgravity: The Impact of Space on Immune Cells

Scientists review and summarize the literature investigating the effects of microgravity on macrophages and monocytes regarding the microgravity environment simulation/generation methods, cell sources, experiment durations, and parameters of interest utilized within the field.
[npj Microgravity]
Ludtka, C., Silberman, J., Moore, E., & Allen, J. B. (2021). Macrophages in microgravity: the impact of space on immune cells. Npj Microgravity, 7(1), 1–10. https://doi.org/10.1038/s41526-021-00141-z Cite
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Adaptive Immunity at the Crossroads of Autophagy and Metabolism

The authors summarize and discuss the versatile roles of autophagy in regulating cellular metabolism and the implications of autophagy for immune cell function and fate, especially for T and B lymphocytes.
[Cellular & Molecular Immunology]
Metur, S. P., & Klionsky, D. J. (2021). Adaptive immunity at the crossroads of autophagy and metabolism. Cellular & Molecular Immunology, 1–10. https://doi.org/10.1038/s41423-021-00662-3 Cite
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Peripheral Nerve Resident Macrophages and Schwann Cells Mediate Cancer-Induced Pain

Researchers report that depletion of sciatic nerve resident macrophages (rMΦ) in mice attenuated mechanical/cold hypersensitivity and spontaneous pain evoked by intraplantar injection of melanoma or lung carcinoma cells. Targeted deletion of transient receptor potential ankyrin 1 (Trpa1) revealed a key role for Schwann cell TRPA1 in sciatic nerve rMΦ expansion and pain-like behaviors.
[Cancer Research]
Logu, F. D., Marini, M., Landini, L., Araujo, D. S. M. de, Bartalucci, N., Trevisan, G., Bruno, G., Marangoni, M., Schmidt, B. L., Bunnett, N. W., Geppetti, P., & Nassini, R. (2021). Peripheral Nerve Resident Macrophages and Schwann Cells Mediate Cancer-induced Pain. Cancer Research. https://doi.org/10.1158/0008-5472.CAN-20-3326 Cite
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A Tumor-Specific Mechanism of Treg Enrichment Mediated by the Integrin αvβ8

Researchers describe a mechanism for Treg enrichment in mouse and human tumors mediated by the αvβ8 integrin.
[Science Immunology]
Seed, R. I., Kobayashi, K., Ito, S., Takasaka, N., Cormier, A., Jespersen, J. M., Publicover, J., Trilok, S., Combes, A. J., Chew, N. W., Chapman, J., Krummel, M. F., Lou, J., Marks, J., Cheng, Y., Baron, J. L., & Nishimura, S. L. (2021). A tumor-specific mechanism of Treg enrichment mediated by the integrin αvβ8. Science Immunology, 6(57). https://doi.org/10.1126/sciimmunol.abf0558 Cite
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Single-Cell Profiling of Myeloid Cells in Glioblastoma across Species and Disease Stage Reveals Macrophage Competition and Specialization

Scientists employed single-cell RNA sequencing and CITE-seq to map the glioblastoma immune landscape in mouse tumors and in patients with newly diagnosed disease or recurrence.
[Nature Neuroscience]
Pombo Antunes, A. R., Scheyltjens, I., Lodi, F., Messiaen, J., Antoranz, A., Duerinck, J., Kancheva, D., Martens, L., De Vlaminck, K., Van Hove, H., Kjølner Hansen, S. S., Bosisio, F. M., Van der Borght, K., De Vleeschouwer, S., Sciot, R., Bouwens, L., Verfaillie, M., Vandamme, N., Vandenbroucke, R. E., … Movahedi, K. (2021). Single-cell profiling of myeloid cells in glioblastoma across species and disease stage reveals macrophage competition and specialization. Nature Neuroscience, 1–16. https://doi.org/10.1038/s41593-020-00789-y Cite
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