Scientists report that ubiquitin-specific protease 19 acted as an anti-inflammatory switch that inhibited inflammatory responses and promoted M2-like macrophage polarization.
6445218 BW8CL3PQ items 1 apa default asc 1
Liu, T., Wang, L., Liang, P., Wang, X., Liu, Y., Cai, J., She, Y., Wang, D., Wang, Z., Guo, Z., Bates, S., Xia, X., Huang, J., & Cui, J. (2020). USP19 suppresses inflammation and promotes M2-like macrophage polarization by manipulating NLRP3 function via autophagy. Cellular & Molecular Immunology, 1–12. https://doi.org/10.1038/s41423-020-00567-7 Cite
To determine if Hhex was intrinsically required throughout NK cell development or for NK cell function, scientists generated mice that specifically lacked Hhex in NK cells.
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Goh, W., Scheer, S., Jackson, J. T., Hediyeh-Zadeh, S., Delconte, R. B., Schuster, I. S., Andoniou, C. E., Rautela, J., Degli-Esposti, M. A., Davis, M. J., McCormack, M. P., Nutt, S. L., & Huntington, N. D. (2020). Hhex Directly Represses BIM-Dependent Apoptosis to Promote NK Cell Development and Maintenance. Cell Reports, 33(3). https://doi.org/10.1016/j.celrep.2020.108285 Cite
Through an interaction-dependent labeling approach, intratumoral TSA-reactive CD4 +, CD8 + T cells, and TSA-suppressive CD4 + T cells could be detected and separated from bystander T cells based on their cell-surface enzymatic fucosyl-biotinylation.
Researchers report that certain ligands could be obscured by the glycosaminoglycans and glycoproteins that coat pathogenic as well as malignant phagocytic targets.
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The single deletion of tumor necrosis factor receptor (TNFR) 1 induced subclinical colonic epithelial dysfunction and mucosal immune abnormalities, including accumulation of neutrophils and depletion of B cells.
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Liu, C. Y., Tam, S. S., Huang, Y., Dubé, P. E., Alhosh, R., Girish, N., Punit, S., Nataneli, S., Li, F., Bender, J. M., Washington, M. K., & Polk, D. B. (2020). TNF Receptor 1 Promotes Early-Life Immunity and Protects against Colitis in Mice. Cell Reports, 33(3). https://doi.org/10.1016/j.celrep.2020.108275 Cite
The mechanisms by which regulatory T (Treg) cells differentially control allergic and autoimmune responses remain unclear. Researchers showed that Treg cells in food allergy had decreased expression of transforming growth factor beta 1 (TGF-β1) because of interleukin-4- and signal transducer and activator of transciription-6-dependent inhibition of Tgfb1 transcription.
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Turner, J. A., Stephen-Victor, E., Wang, S., Rivas, M. N., Abdel-Gadir, A., Harb, H., Cui, Y., Fanny, M., Charbonnier, L.-M., Fong, J. J. H., Benamar, M., Wang, L., Burton, O. T., Bansal, K., Bry, L., Zhu, C., Li, Q.-Z., Clement, R. L., Oettgen, H. C., … Chatila, T. A. (2020). Regulatory T Cell-Derived TGF-β1 Controls Multiple Checkpoints Governing Allergy and Autoimmunity. Immunity, 0(0). https://doi.org/10.1016/j.immuni.2020.10.002 Cite
Scientists report a potent synergy between selective SIRPα blockade and immune checkpoint blockade in increasing memory T cell responses and reverting exclusion in syngeneic and orthotopic tumor models.
[Journal of Clinical Investigation]
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Gauttier, V., Pengam, S., Durand, J., Biteau, K., Mary, C., Morello, A., Néel, M., Porto, G., Teppaz, G., Thepenier, V., Danger, R., Vince, N., Wilhelm, E., Girault, I., Abes, R., Ruiz, C., Trilleaud, C., Ralph, K.-L., Trombetta, E. S., … Poirier, N. (2020). Selective SIRPα blockade reverses tumor T cell exclusion and overcomes cancer immunotherapy resistance. The Journal of Clinical Investigation, 130(11). https://doi.org/10.1172/JCI135528 Cite
The assessment included incidence of biopsy confirmed acute rejection, assessment of nTreg infusion related adverse effects, and signs of over immunosuppression.
[British Medical Journal]
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Roemhild, A., Otto, N. M., Moll, G., Abou-El-Enein, M., Kaiser, D., Bold, G., Schachtner, T., Choi, M., Oellinger, R., Landwehr-Kenzel, S., Juerchott, K., Sawitzki, B., Giesler, C., Sefrin, A., Beier, C., Wagner, D. L., Schlickeiser, S., Streitz, M., Schmueck-Henneresse, M., … Reinke, P. (2020). Regulatory T cells for minimising immune suppression in kidney transplantation: phase I/IIa clinical trial. BMJ, 371. https://doi.org/10.1136/bmj.m3734 Cite
Scientists demonstrated that envelope glycoproteins (Env)-induced oxidative stress was responsible for their death by apoptosis. Moreover, they report that peroxisomes, organelles involved in the control of oxidative stress, are targeted by Env-mediated autophagy.
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The authors showed that depletion of transforming growth factor-β receptor 2 (TGFβR2) in CD4+ T cells, but not CD8+ T cells, halts cancer progression as a result of tissue healing and remodeling of the blood vasculature, causing cancer cell hypoxia and death in distant avascular regions.
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Liu, M., Kuo, F., Capistrano, K. J., Kang, D., Nixon, B. G., Shi, W., Chou, C., Do, M. H., Stamatiades, E. G., Gao, S., Li, S., Chen, Y., Hsieh, J. J., Hakimi, A. A., Taniuchi, I., Chan, T. A., & Li, M. O. (2020). TGF-β suppresses type 2 immunity to cancer. Nature, 1–6. https://doi.org/10.1038/s41586-020-2836-1 Cite
The authors summarize what they have learned about GPCRs that transduce anti-inflammatory signals, their structures and signaling pathways and the prospect of targeting these receptors for novel anti-inflammatory therapies.
[Acta Pharmacologica Sinica]