the liver is a central player in immunoregulation. Altered immune responses are tightly associated with the development of non-alcoholic steatohepatitis and hepatocellular carcinoma.
[Experimental and Molecular Medicine]
Researchers generated distinct imageable syngeneic mouse glioblastoma-tumor models and utilized RNA-sequencing, CyTOF and correlative immunohistochemistry to assess immune-profiles in these models.
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The small GTPase Rap1 deficiency, as well as chemokine stimulation and the introduction of the active form of Rap1, Rap1V12, enhanced the binding of NZ-1 to the PA-tagged mutant integrin, and increased the binding affinity to mucosal addressing cell adhesion molecule-1.
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Corbus Pharmaceuticals Holdings, Inc. announced the completion of subject enrollment in DETERMINE, a Phase III study assessing the efficacy and safety of lenabasum for the treatment of dermatomyositis. The company expects to report topline results from this study in the fourth quarter of 2021.
[Corbus Pharmaceuticals Holdings, Inc.]
The role of platelets in liver biology and pathophysiology has attracted increased attention during the last decade.
Understanding the precise immunological mechanisms that underlie the efficacy of chemotherapy has the potential not only to enable the identification of superior biomarkers of response but also to accelerate the development of synergistic combination regimens that enhance the clinical effectiveness of immune checkpoint inhibitors relative to their effectiveness as monotherapies.
[Nature Reviews Clinical Oncology]
Scientists provide an updated discussion on DNA methylation alterations in autoimmune rheumatic diseases and the advantages and disadvantages of using these markers in clinical practice.
[Nature Reviews Rheumatology]
Microbial exposures at the intestinal mucosa generated oligoclonal responses that differed from those of germ-free mice, and from the diverse repertoire that was generated after intravenous systemic exposure to microbiota.
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Li, H., Limenitakis, J. P., Greiff, V., Yilmaz, B., Schären, O., Urbaniak, C., Zünd, M., Lawson, M. A. E., Young, I. D., Rupp, S., Heikenwälder, M., McCoy, K. D., Hapfelmeier, S., Ganal-Vonarburg, S. C., & Macpherson, A. J. (2020). Mucosal or systemic microbiota exposures shape the B cell repertoire. Nature, 1–5. https://doi.org/10.1038/s41586-020-2564-6 Cite
Scientists determined whether BXD recombinant inbred mice strains were more suitable than C57BL/6J mice for the understanding of the relationship between antioxidant response and inflammatory responses.
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Investigators demonstrated that intestinal G protein-coupled receptor 35 (Gpr35) expression was microbiota dependent and enhanced upon inflammation. Moreover, murine GPR35+ colonic macrophages were characterized by enhanced production of pro-inflammatory cytokines.
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Kaya, B., Doñas, C., Wuggenig, P., Diaz, O. E., Morales, R. A., Melhem, H., Hernández, P. P., Kaymak, T., Das, S., Hruz, P., Franc, Y., Geier, F., Ayata, C. K., Villablanca, E. J., & Niess, J. H. (2020). Lysophosphatidic Acid-Mediated GPR35 Signaling in CX3CR1+ Macrophages Regulates Intestinal Homeostasis. Cell Reports, 32(5). https://doi.org/10.1016/j.celrep.2020.107979 Cite
The authors showed that expression of atypical chemokine receptor 3 defined two equal-sized populations of mouse marginal B cells
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Twitter has suspended the account of MeTooSTEM founder BethAnn McLaughlin after allegations emerged that the former Vanderbilt University neuroscientist fabricated the Twitter account of an apparently nonexistent female Native American anthropologist at Arizona State University who had claimed to be an anonymous victim of sexual harassment by a Harvard professor.