Researchers showed that high-fat diet feeding greatly suppressed the expression of disulfide-bond A oxidoreductase-like protein (DsbA-L), a mitochondria-localized chaperone protein, in adipose-resident T cells, which correlated with reduced T cell mitochondrial function.
[Nature Communications]
Zhou, H., Peng, X., Hu, J., Wang, L., Luo, H., Zhang, J., Zhang, Y., Li, G., Ji, Y., Zhang, J., Bai, J., Liu, M., Zhou, Z., & Liu, F. (2021). DsbA-L deficiency in T cells promotes diet-induced thermogenesis through suppressing IFN-γ production. Nature Communications, 12(1), 326. https://doi.org/10.1038/s41467-020-20665-4 Cite
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