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Immune Regulation News
Immune Regulation News is an online resource covering research into the regulation, suppression, and modulation of the immune system.
Rescuing Dendritic Cell Interstitial Motility Sustains Antitumour Immunity
[Nature] Through longitudinal analysis of human and mouse tumours, researchers observed a progressive decrease in migratory conventional dendritic cells in the tumour draining lymph nodes during tumour progression.
Transcription Factor T-Bet Regulates the Maintenance and Differentiation Potential of Lymph Node and Lung Effector Memory B Cell Subsets
[Immunity] Researchers characterized multiple transcriptionally distinct clusters of mature, somatically mutated nucleoprotein-specific memory B cells in lymph nodes and lungs of influenza-infected mice.
Mitochondrial 1-Carbon Metabolism Drives CD34-Lineage Cells to Differentiate into T Follicular Helper Cells to Form Tertiary Lymphoid Organs in Transplant Arteriosclerosis
[Circulation] Researchers provided insights into the critical role of mitochondrial 1-carbon metabolism and MTHFD2 in governing the differentiation of CD34-lineage cells into Tfh cells, which contributed to tertiary lymphoid organ formation in transplant vasculopathy, offering potential therapeutic targets to enhance transplant outcomes.
Innate Immunity and the NF-κB Pathway Control Prostate Stem Cell Plasticity, Reprogramming, and Tumor Initiation
[Nature Cancer] Investigators showed that Pten deletion in basal cells led to distinct cell fate reprogramming and tumor initiation in a regionalized manner.
FXR Inhibition Functions As a Checkpoint Blockade of the Pathogenic Tfh Cell Response in Lupus
[Cellular & Molecular Immunology] Investigators showed that farnesoid X receptor (FXR) was relatively upregulated in T follicular helper (Tfh) cells. Genetic deletion of Fxr restrains Tfh expansion both at steady state and in pristane-induced lupus.
Piezo1 deletion enhances cross-priming of CD8+ T cells by tumor-infiltrating CD11b+ dendritic cells
[Journal For Immunotherapy of Cancer] Investigators described an association between mechanosensation and cross-presentation by cDC2A cells. Their findings may be impactful in improving the continued development of dendritic cell vaccines whose success hinges on proper antigen processing and presentation to cytotoxic T cells in the tumor microenvironment.
In Vivo Accumulation of Regulatory T Cells using Eliglustat-Loaded Cryogels.
[Advanced Healthcare Materials] Scientists have demonstrated that eliglustat-loaded cryogels offer a simple yet effective biomaterial strategy to directly boost Treg cells in vivo, potentially providing a targeted method to treat various inflammatory and autoimmune diseases.
Palmitoylethanolamide (PEA) Induces an Increase in Spleen Regulatory T Cells, Reduces CD8+ Cells and TNF-α Levels in Target Organs, and Protects Mice from Graft-Versus-Host...
[Immunology] Researchers found that palmitoylethanolamide created an immunoregulatory environment in the spleen by reducing the activation of CD3+CD4+ cells.
Lung Adenocarcinoma-Derived IFN-γ Promotes Growth by Modulating CD8+ T Cell Production of CCR5 Chemokines
[European Journal of Clinical Investigation] Researcher found that CD8+ T cells promote homing of CD4+Foxp3+ T regulatory cells to the tumor bed by increasing levels of CCR5 chemokines in the tumor microenvironment in an IFN-γ and TNF-α dependent manner.
The Role of Double-Negative B Cells in the Pathogenesis of Systemic Lupus Erythematosus
[Autoimmunity Reviews] The authors provide an updated synthesis of current research on double negative B cells, with a focus on their origins, developmental trajectories in systemic lupus erythematosus, and potential as precision therapeutic targets.
Th17 Cells in Cancer: Plasticity-Driven Immunopathology and Therapeutic Opportunity
[Immunology and Cell Biology] Scientists explore how T-helper 17 (Th17) cells mediate paradoxical roles in tumor biology, promoting either tumor progression or antitumor immunity depending on molecular context.
Immunoregulatory Effects of Traditional Chinese Medicine and Its Ingredients on Psoriasis
[International Immunopharmacology] Investigators provide an overview of the roles for various immune cells in the pathogenesis of psoriasis and the regulatory effects of Traditional Chinese Medicine and its ingredients on them.
For over a decade, Immune Regulation News has been keeping the scientific community up-to-date with the latest research and reviews related to immune regulation. Key research areas covered include the roles of regulatory T cells (Treg cells) in autoimmunity and self-reactivity, as well as immune response to disease, transplantation and cancer. We also provide vital updates on the latest jobs and upcoming events in the field of immunology.
