CXCR3 Regulates Stem and Proliferative CD8+ T Cells during Chronic Infection by Promoting Interactions with DCs in Splenic Bridging Channels

The authors observed distinct locations for parasite-specific T cell subsets, implying a link between differentiation and anatomical niches in the spleen.
[Cell Reports]
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Gut Microbiota–Derived Metabolite 3-Idoleacetic Acid Together with LPS Induces IL-35+ B Cell Generation

Scientists investigated the regulatory effects of the gut microbiota on IL-35+ cells by using genetically modified mouse models of obesity.
[Microbiome]
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Effector Memory CD4+ T Cells Induce Damaging Innate Inflammation and Autoimmune Pathology by Engaging CD40 and TNFR on Myeloid Cells

Investigators identified a critical signaling node that was engaged by effector memory T cells to mobilize a broad proinflammatory program in the innate immune system.
[Science Immunology]
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ASLAN Pharmaceuticals Initiates Phase IIb Study of ASLAN004 (Eblasakimab) in Moderate-to-Severe Atopic Dermatitis

ASLAN Pharmaceuticals announced that it has screened the first patient in its Phase IIb dose-ranging clinical study of eblasakimab in adults with moderate-to-severe atopic dermatitis.
[ASLAN Pharmaceuticals]
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Interleukin-37 Promotes Colitis-Associated Carcinogenesis via SIGIRR-Mediated Cytotoxic T Cells Dysfunction

Scientists found that IL-37 transgenic mice were highly susceptible to colitis-associated colorectal cancer and suffered from dramatically increased tumor burdens in colon.
[Signal Transduction and Targeted Therapy]
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Immuno-Engineered Nanodecoys for the Multi-Target Anti-Inflammatory Treatment of Autoimmune Diseases

IFN-γ treatment induced remarkable PD-L1 expression on PD-L1-expressing macrophage membrane (PRM), thereby allowing PRM nanodecoys to bind mPD-1 on CD4+ T cell surfaces or neutralize free sPD-1, which reconstructed the PD-1/PD-L1 inhibitory axis to suppress CD4+ T cell activation and restore immune tolerance.
[Advanced Materials]
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ISM1 Protects Lung Homeostasis via Cell-Surface GRP78-Mediated Alveolar Macrophage Apoptosis

Researchers reported that absence of isthmin 1 (ISM1) in mice led to increase in both alveolar macrophages number and functional heterogeneity, with enduring lung inflammation, progressive emphysema, and significant lung function decline, phenotypes similar to human obstructive pulmonary disease.
[Proceedings of the National Academy of Sciences of the United States of America]
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Development of the Immune System in the Human Embryo

Fetal B-1 and B-2 B cells involved in innate and adaptive immune responses, respectively, arise in staggered waves of development from distinct progenitors.
[Pediatric Research]
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Inhalation of Dimethyl Fumarate-Encapsulated Solid Lipid Nanoparticles Attenuate Clinical Signs of Experimental Autoimmune Encephalomyelitis and Pulmonary Inflammatory Dysfunction in Mice

Scientists investigated the potential effects of solid lipid nanoparticles containing dimethyl fumarate, administered by inhalation on the clinical signs, central nervous system inflammatory response, and lung function changes in mice with experimental autoimmune encephalomyelitis.
[Clinical Science]
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DJ-1 Depletion Prevents Immunoaging in T Cell Compartments

Investigators showed that loss of DJ-1 encoded by PARK7/DJ-1, causing early-onset familial Parkinson’s disease, unexpectedly diminished signs of immunoaging in T cell compartments of both human and mice.
[EMBO Reports]
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Revelation Biosciences, Inc. Announces First Patient Enrolled and Dosed in Phase Ib Clinical Study of REVTx-99 for the Treatment of Allergic Rhinitis

Revelation Biosciences, Inc. announced that the first patient has been enrolled and dosed in a Phase Ib clinical study to evaluate the potential utility of REVTx-99 for treating patients with allergic rhinitis and patients with chronic nasal congestion without polyps.
[Revelation Biosciences, Inc.]
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