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Immune Regulation News
Immune Regulation News is an online resource covering research into the regulation, suppression, and modulation of the immune system.
A Human STAT3 Gain-of-Function Variant Drives Local Th17 Dysregulation and Skin Inflammation in Mice
[Journal of Experimental Medicine] To study tissue-specific immune dysregulation, investigators used a mouse model carrying a missense variant that caused human disease. They observed spontaneous and imiquimod-induced skin inflammation associated with cell-intrinsic local Th17 responses in STAT3 gain-of-function mice.
CTLA-4-Expressing ILC3s Restrain Interleukin-23-Mediated Inflammation
[Nature] Scientists identified potent upregulation of the immunoregulatory checkpoint molecule cytotoxic T-lymphocyte-associated antigen-4 on group 3 innate lymphoid cells. This pathway was activated by gut microbes and interleukin-23 in a FOXO1- and STAT3-dependent manner.
A Dual-Enzyme-Like Photosensitive Nanozyme for Remodeling the Tumor Immunosuppressive Microenvironment to Enhance Immunotherapy
[Biomaterials] Investigators developed a dual-enzyme-like photosensitive nanozyme to remodel the tumor immunosuppressive microenvironment and induced the tumor infiltration of cytotoxic T lymphocytes.
Immunological Synapse Formation Between T Regulatory Cells and Cancer-Associated Fibroblasts Promotes Tumour Development
[Nature Communications] Using multiple tumor models and biopsies from cancer patients, researchers reported that α-SMA+ cancer-associated fibroblasts could form immunological synapses with Foxp3+ regulatory T cells in tumors.
Regulation of SETD2 Maintains Immune Regulatory Function in Macrophages to Suppress Airway Allergy
[Immunology] Researchers clarified the role of SET domain-containing 2 (SETD2) in regulating the immune property of macrophages (Mφs). The Mφs were isolated from the bronchoalveolar lavage fluid and analyzed through flow cytometry and RNA sequencing.
Exploring T Cell Receptor Repertoires in Myocardial Diseases
[Circulation Research] The authors discuss key aspects underlying the generation of T cell receptors (TCRs) and emerging tools for their study in the context of myocardial diseases. They outline how exploring TCR repertoires could lead to a deeper understanding of myocardial pathophysiological principles and potentially serve as diagnostic tools.
MoonLake Immunotherapeutics Announces Positive Regulatory Feedback from both FDA and EMA on Path for the Phase III Program for the Nanobody® sonelokimab in Psoriatic...
[MoonLake Immunotherapeutics] MoonLake Immunotherapeutics announced the successful outcome of its end-of-Phase II interactions with the US FDA with both regulatory bodies unanimously supporting MoonLake’s proposed approach for advancing its Phase III program of the Nanobody® sonelokimab in psoriatic arthritis.
Super-resolution Imaging of T Lymphocyte Activation Reveals Chromatin Decondensation and Disrupted Nuclear Envelope
[Communications Biology] Using stochastic optical reconstruction microscopy (STORM), scientists observed dramatic de-condensation of chromatin and the disruption of nuclear envelope at a nanoscale resolution upon T lymphocyte activation.
Necroptosis Stimulates Interferon-Mediated Protective Anti-tumor Immunity
[Cell Death & Disease] Scientists selectivly induced RIPK3-dependent necroptosis or apoptosis with minimal NF-κB-dependent inflammatory cytokine expression. This protective effect required CD4+/sup> T cells rather than CD8+/sup> T cells and was dependent on host type I interferon signaling.
Selective Depletion of Tumor-Infiltrating Regulatory T Cells with BAY 3375968, a Novel FC-Optimized Anti-CCR8 Antibody
[Clinical and Experimental Medicine] The chemokine receptor 8 (CCR8) was found to be predominantly expressed on Tregs within the tumor microenvironment of both humans and mice, representing a unique target for selective depletion of tumor-residing Tregs.
Bacteroides uniformis CECT 7771 Requires Adaptive Immunity to Improve Glucose Tolerance but Not to Prevent Body Weight Gain in Diet-Induced Obese Mice
[Microbiome] Investigators evaluated the effects of B. uniformis on energy homeostasis, and intestinal immunity in wild-type and Rag1-deficient mice with diet-induced obesity. They assessed whether it needed to be viable to exert its beneficial effects on obesity and to directly induce immunoregulatory effects.
Peripheral Immune Cells Contribute to the Pathogenesis of Alzheimer’s Disease
[Molecular Neurobiology] Scientists investigated the potential causal association between peripheral immune cells and Alzheimer's disease (AD) by using a two-sample Mendelian randomization analysis (TSMR). They deciphered the causal relationship between AD and 731 types of peripheral immune cell parameters from the TBNK, Treg, and B cell panels.
For over a decade, Immune Regulation News has been keeping the scientific community up-to-date with the latest research and reviews related to immune regulation. Key research areas covered include the roles of regulatory T cells (Treg cells) in autoimmunity and self-reactivity, as well as immune response to disease, transplantation and cancer. We also provide vital updates on the latest jobs and upcoming events in the field of immunology.
