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Immune Regulation News
Immune Regulation News is an online resource covering research into the regulation, suppression, and modulation of the immune system.
The Subfornical Organ Is a Nucleus for Gut-Derived T Cells that Regulate Behavior
[Nature] Investigators showed that the subfornical organ of the brain is a nucleus for parenchymal αβ T cells in the steady-state brain in both mice and humans.
Enhancer-Driven Gene Regulatory Networks Reveal Transcription Factors Governing T Cell Adaptation and Differentiation in the Tumor Microenvironment
[Immunity] Scientists revealed mechanisms of tissue-resident memory CD8+ T cell-like tumor-infiltrating lymphocytes differentiation and provide a framework for considering tissue residency in the context of CD8+ T cell heterogeneity in the tumor microenvironment.
MicroRNA-142-3p Shuttling in Extracellular Vesicles Marks Regulatory T Cell Dysfunction in Multiple Sclerosis
[Science Translational Medicine] Scientists found that Treg-extracellular vesicles from healthy individuals inhibit CD4+ conventional T cells by shuttling miR-142-3p from the Treg cell to the Tconv cell.
Peripherally Induced RORγT+ Skin-Resident Regulatory T Cells Mediate the Efficacy of Allergen-Specific Immunotherapy
[Science Translational Medicine] Researchers investigated the role and origin of specific Treg lineages in allergen-specific immunotherapy with human atopic dermatitis (AD) samples and with a mouse model of AD.
Hepatitis B Virus Surface Antigen Drives T Cell Immunity through Non-Canonical Antigen Presentation in Mice
[Nature Communications] Using preclinical mouse models, investigators showed that, following HBsAg expression, the intrahepatic Batf3+XCR1+CCR7- conventional dendritic cell subset cDC1 presents HBsAg by MHC-I cross-dressing, driving CD8+ T cell response.
Immunosuppressive Cytokine-Tethered Hydrogel for Treating Rheumatoid Arthritis
[Advanced Healthcare Materials] To address challenges with current rheumatoid arthritis therapies, an interleukin-4-tethered, hyaluronic acid-based hydrogel was developed that withstands repeated mechanical stress in the joint space while fostering an immunomodulatory environment.
N-Glycosylated LTβR Increases the Th17/Treg Cell Ratio in Liver Cancer by Blocking RORC Ubiquitination and FOXP3 Transcription
[Cell Death & Disease] Investigators employed primary or subcutaneous mouse hepatocellular carcinoma (HCC) models and flow cytometry to study the impact of conditional knock-in of Ltbr on CD4+ T cell differentiation and response, particularly the Th17/Treg cell ratio, and its influence on HCC progression.
Indolepropionic Acid Modulates the Immune Response in Allergic Rhinitis through the AKT/CEBPB/IL‑10 Signaling Pathway
[Molecular Medicine Reports] An experimental mouse model of allergic rhinitis was established by sensitizing and exposing the mice to allergens, followed by the administration of indolepropionic acid via gavage.
Exosomal TIMP4 from Myocardial Cell Relieves Heart Failure by Influencing Th17/Treg Balance
[Cardiology] Researchers elucidated the impact of tissue inhibitor of metalloproteinase-4 (TIMP4) on heart failure pathogenesis, with a particular emphasis on its influence on T helper 17 and Treg lymphocyte populations.
Tumor Immune Evasion and the Let-7 Family: Insights into Mechanisms and Therapies
[Naunyn-Schmiedebergs Archives of Pharmacology] The authors explore the integral role of the let-7 family of microRNAs in mediating tumor immune evasion, particularly how these regulators influence the tumor microenvironment and immune cell functionality.
Navigator Medicines Announces First Participants Dosed in a Phase Ib Trial of NAV-240, a Potential Best-in-Class Anti-OX40L, and Anti-TNFα Bispecific Antibody Therapeutic for Autoimmune...
[Navigator Medicines, Inc. (Business Wire)] Navigator Medicines, Inc. announced that it dosed the first subjects in a Phase Ib multiple-ascending dose study in healthy volunteers, evaluating the safety, tolerability, pharmacokinetics and pharmacodynamics of NAV-240 after repeated administration.
N-Glycosylated LTβR Increases the Th17/Treg Cell Ratio in Liver Cancer by Blocking RORC Ubiquitination and FOXP3 Transcription
[Cell Death & Disease] Researchers employed primary or subcutaneous mouse HCC models and flow cytometry to study the impact of conditional knock-in of Ltbr on CD4+ T cell differentiation and response, particularly the Th17/Treg cell ratio, and its influence on HCC progression.
For over a decade, Immune Regulation News has been keeping the scientific community up-to-date with the latest research and reviews related to immune regulation. Key research areas covered include the roles of regulatory T cells (Treg cells) in autoimmunity and self-reactivity, as well as immune response to disease, transplantation and cancer. We also provide vital updates on the latest jobs and upcoming events in the field of immunology.
