Immune Regulation News

Immune Regulation News is an online resource covering research into the regulation, suppression, and modulation of the immune system.

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Blockade of CCR5 and CXCR3 Attenuates Murine Acute Graft-Versus-Host Disease Through Modulating Donor-Derived T Cell Distribution and Function

May 24, 2024

[International Immunology] A mouse model of aGVHD was established to assess the efficacy of CCR5 or/and CXCR3 blockade on the development of aGVHD. The immunomodulatory effect on T cells was assessed by evaluating T cell proliferation, viability, and differentiation.

Icaritin-Curcumol Activates CD8+ T Cells Through Regulation of Gut Microbiota and the DNMT1/IGFBP2 Axis to Suppress the Development of Prostate Cancer

May 24, 2024

[Journal of Experimental & Clinical Cancer Research] Investigators explored the effects of the combination of icariin (ICA) and curcumol (CUR) on gut microbiota, metabolism, and immunity in prostate cancer. Short-chain fatty acids in mouse feces, and the effect of ICA-CUR on T-cell immunity, IGFBP2, and DNMT1 were examined.

Brain Cancer Canada Awards an $80,000 Research Grant to the Development of Dual Function Therapies That Harness the Body’s Own Immune System to Kill...

May 24, 2024

[Brain Cancer Canada] Brain Cancer Canada is excited to announce $80,000 research grant has been awarded to Dr. Peter Stirling, PhD, Associate Professor at the University of British Columbia and Senior Scientist at the Terry Fox Laboratory, BC Cancer.

ARID1A Suppresses R-Loop-Mediated STING-Type I Interferon Pathway Activation of Anti-Tumor Immunity

May 24, 2024

[Cell] Investigators showed that ARID1A loss in murine models was sufficient to induce anti-tumor immune phenotypes observed in ARID1A mutant human cancers, including increased CD8+ T cell infiltration and cytolytic activity.

CD200R Activation on Naïve T Cells by B Cells Induces Suppressive Activity of T Cells via IL-24

May 23, 2024

[Cellular and Molecular Life Sciences] The authors investigated the role of CD200 in Treg-of-B (P) cell generation. They revealed that Peyer’s patch B cells expressed CD200 to activate the CD200R on T cells and initiated the process of Treg-of-B (P) cell generation.

The Integration of Metabolic and Proteomic Data Uncovers an Augmentation of the Sphingolipid Biosynthesis Pathway During T-Cell Differentiation

May 23, 2024

[Communications Biology] Scientists found that the sphingolipid biosynthesis pathway was commonly activated in Th1, Th2, Th17, and iTreg cells and that inhibition of this pathway led to the suppression of Th17 and iTreg cells differentiation.

High Common-γ Cytokine Receptor Levels Promote Expression of Interleukin-2/Interleukin-7 Receptor α-Chains With Implications on T-Cell Differentiation and Function

May 23, 2024

[Immunology] Researchers studied the influence of differential common-γ receptor chain (γc) expression on the expression of the IL-2Rα, the IL-7Rα, and the differentiation of activated naïve T cells. They fine-tuned the regulation of γc expression in human primary naïve T cells by lentiviral transduction using small hairpin (sh)RNAs and γc cDNA.

Treg-Derived TGF-β1 Dampens cGAS-STING Signaling to Downregulate the Expression of Class I MHC Complex in Multiple Myeloma

May 21, 2024

[Scientific Reports] To investigate Treg's influence on multiple myeloma (MM) cells, researchers established a co-culture system using Tregs from MM patients and the MM cell lines in vitro and assessed the effects of intervening in the relevant pathways connecting Tregs and MM cells in vivo.

Combination of Proton- or X-Irradiation with Anti-PDL1 Immunotherapy in Two Murine Oral Cancers

May 21, 2024

[Scientific Reports] Scientists compared responses for two syngeneic head and neck cancer tumor models in mice following X-ray or proton irradiation with or without immune checkpoint inhibition.

Foxo3 Regulates Cortical and Medullary Thymic Epithelial Cell Homeostasis With Implications in T Cell Development

May 21, 2024

[Cell Death & Disease] Researchers showed that mice with thymic epithelial cells (TEC)-specific deletion of Foxo3 displayed a disrupted medullary TEC (mTEC) compartment, with a more profound impact on the numbers of CCL21+ and thymic tuft mTEClo subsets.

PKC-θ Is an Important Driver of Fluoride-Induced Immune Imbalance of Regulatory T Cells/Effector T Cells

May 17, 2024

Scientists explored the mechanism of fluoride interference in the immune system and also identify the key indicators of fluoride-induced immune damage. [Human Reproduction] AbstractGraphical Abstract

Bevacizumab Induces Ferroptosis and Enhances CD8+ T Cell Immune Activity in Liver Cancer via Modulating HAT1 and Increasing IL-9

May 17, 2024

Researchers investigated whether and how bevacizumab regulated ferroptosis and immune activity in liver cancer. They performed RNA-sequencing in bevacizumab-treated human liver cancer cell line...

For over a decade, Immune Regulation News has been keeping the scientific community up-to-date with the latest research and reviews related to immune regulation. Key research areas covered include the roles of regulatory T cells (Treg cells) in autoimmunity and self-reactivity, as well as immune response to disease, transplantation and cancer. We also provide vital updates on the latest jobs and upcoming events in the field of immunology.