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Immunology of Infectious Disease News
Immunology of Infectious Disease News is an online resource dedicated to covering the latest research and developments in the field of infectious diseases.
HIV and Cardiovascular Disease
[Circulation Research] The authors explore the current state of knowledge in HIV and cardiovascular disease, exploring risk factors, therapies, and future research directions.
Immunogenicity of 2 Therapeutic Mosaic HIV-1 Vaccine Strategies in Individuals With HIV-1 on Antiretroviral Therapy
[NPJ Vaccines] Scientists evaluated the safety and immunogenicity of 2 mosaic vaccine regimens in virologically suppressed individuals that had initiated antiretroviral therapy during the chronic phase of infection, exemplifying the majority of people living with HIV-1.
Intranasal Vaccination With an NDV-Vectored SARS-CoV-2 Vaccine Protects Against Delta and Omicron Challenges
[NPJ Vaccines] Researchers utilized a Newcastle Disease virus (NDV) vectored vaccine expressing the ancestral SARS-CoV-2 spike protein in a pre-fusion stabilized (PFS) chimeric conformation. When delivered intranasally, NDV-PFS protected both Syrian hamsters and K18 mice against Delta and Omicron SARS-CoV-2 variants of concern.
Development of a Nucleoside-Modified mRNA Vaccine Against Clade 2.3.4.4b H5 Highly Pathogenic Avian Influenza Virus
[Nature Communications] Scientists generated an mRNA lipid nanoparticle (LNP) vaccine encoding the hemagglutinin (HA) glycoprotein from a clade 2.3.4.4b H5 isolate. The H5 mRNA-LNP vaccine elicits strong T cell and antibody responses in female mice, including neutralizing antibodies and broadly-reactive anti-HA stalk antibodies.
Nanomechanical Collective Vibration of SARS-CoV-2 Spike Proteins
The multidomain collective dynamics on the trimer of the spike protein was analyzed using normal mode analysis. A common nanomechanical profile was identified in...
Identifying SARS-CoV-2 Variants Using Single-Molecule Conductance Measurements
Researchers demonstrated that RNA-based, single-molecule conductance experiments could be used to identify specific variants of SARS-CoV-2.
[ACS Sensors] Abstract
Characterization of Novel Influenza-Derived HLA-B*18:01-Restricted Epitopes
[Clinical & Translational Immunology] Scientists assessed the immunogenicity of six recently published novel influenza-derived peptides identified by mass-spectrometry and predicted to bind to the prevalent HLA-B*18:01 molecule.
The EBI2 Receptor Is Coexpressed with CCR5 in CD4+ T Cells and Boosts HIV-1 R5 Replication
[AIDS] Investigators looked for G protein-coupled receptors (GPCRs) able to modify HIV-1 infection. They identified GPCRs expressed in primary CD4+CCR5+ T cells by multi-RT-qPCR.
STAT1 Regulates Neutrophil Gelatinase B-Associated Lipocalin Induction in Influenza-Induced Myocarditis
[Scientific Reports] Scientists investigated the role of anti-viral STAT1 signaling in influenza-induced myocarditis. Wild-type mice (C57BL/6) were infected with either influenza A/PR/8/34 or control, and cellular response and gene expression analysis from the heart samples were assessed 7 days later.
Analysis of the Components of Mycobacterium tuberculosis Heat-Resistant Antigen (Mtb-HAg) and Its Regulation of γδ T Cell Function
[Cellular & Molecular Biology Letters] Mycobacterium tuberculosis heat-resistant antigen (Mtb-HAg) from the attenuated Mtb H37Ra strain was analyzed by LC‒MS mass spectrometry, and a total of 564 proteins were identified.
Effects of Iron Status on Adaptive Immunity and Vaccine Efficacy: A Review
[Advances In Nutrition] The authors examine the emerging evidence that iron deficiency may limit adaptive immunity and vaccine responses. They discuss the molecular mechanisms and evidence from animal and human studies, highlight important unknowns, and propose a framework of key research questions to better understand iron–vaccine interactions.
Could Bird Flu in Cows Lead to a Human Outbreak? Slow Response Worries Scientists
[Nature] Researchers worry that insufficient collection and reporting of data are hampering efforts to assess the scale of the bird-flu outbreak in US cattle — and could hold back efforts to bring the virus under control.
Immunology of Infectious Disease News was founded to keep the scientific community current with the latest developments in infectious disease research. We feature high-impact publications, news, jobs, and events focused on immune responses to and the development of treatments for infectious diseases such as COVID-19, HIV, hepatitis, tuberculosis, influenza, and malaria.
