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Immunology of Infectious Disease News
Immunology of Infectious Disease News is an online resource dedicated to covering the latest research and developments in the field of infectious diseases.
Nanomechanical Collective Vibration of SARS-CoV-2 Spike Proteins
The multidomain collective dynamics on the trimer of the spike protein was analyzed using normal mode analysis. A common nanomechanical profile was identified in...
Identifying SARS-CoV-2 Variants Using Single-Molecule Conductance Measurements
Researchers demonstrated that RNA-based, single-molecule conductance experiments could be used to identify specific variants of SARS-CoV-2.
[ACS Sensors] Abstract
Characterization of Novel Influenza-Derived HLA-B*18:01-Restricted Epitopes
[Clinical & Translational Immunology] Scientists assessed the immunogenicity of six recently published novel influenza-derived peptides identified by mass-spectrometry and predicted to bind to the prevalent HLA-B*18:01 molecule.
The EBI2 Receptor Is Coexpressed with CCR5 in CD4+ T Cells and Boosts HIV-1 R5 Replication
[AIDS] Investigators looked for G protein-coupled receptors (GPCRs) able to modify HIV-1 infection. They identified GPCRs expressed in primary CD4+CCR5+ T cells by multi-RT-qPCR.
STAT1 Regulates Neutrophil Gelatinase B-Associated Lipocalin Induction in Influenza-Induced Myocarditis
[Scientific Reports] Scientists investigated the role of anti-viral STAT1 signaling in influenza-induced myocarditis. Wild-type mice (C57BL/6) were infected with either influenza A/PR/8/34 or control, and cellular response and gene expression analysis from the heart samples were assessed 7 days later.
Analysis of the Components of Mycobacterium tuberculosis Heat-Resistant Antigen (Mtb-HAg) and Its Regulation of γδ T Cell Function
[Cellular & Molecular Biology Letters] Mycobacterium tuberculosis heat-resistant antigen (Mtb-HAg) from the attenuated Mtb H37Ra strain was analyzed by LC‒MS mass spectrometry, and a total of 564 proteins were identified.
Effects of Iron Status on Adaptive Immunity and Vaccine Efficacy: A Review
[Advances In Nutrition] The authors examine the emerging evidence that iron deficiency may limit adaptive immunity and vaccine responses. They discuss the molecular mechanisms and evidence from animal and human studies, highlight important unknowns, and propose a framework of key research questions to better understand iron–vaccine interactions.
Could Bird Flu in Cows Lead to a Human Outbreak? Slow Response Worries Scientists
[Nature] Researchers worry that insufficient collection and reporting of data are hampering efforts to assess the scale of the bird-flu outbreak in US cattle — and could hold back efforts to bring the virus under control.
Human CD4-Binding Site Antibody Elicited by Polyvalent DNA Prime-Protein Boost Vaccine Neutralizes Cross-Clade Tier-2-HIV Strains
[Nature Communications] Researchers demonstrated that a gp120-based vaccine can elicit antibodies capable of tier 2-HIV neutralization. They reported the isolation and characterization of a CD4-binding site specific monoclonal antibody, HmAb64, from a human volunteer immunized with a polyvalent DNA prime-protein boost HIV vaccine.
Reactivation of a Transplant Recipient’s Inherited Human Herpesvirus 6 and Implications to the Graft
[Journal Of Infectious Diseases] Scientists reported a case of reactivation of a recipient´s inherited chromosomally integrated human herpesvirus 6 (iciHHV-6B) and subsequent infection of the graft. Using a novel approach integrating the analysis of viral and mitochondrial DNAs, they located the iciHHV-6B intra-graft.
The Presence of Cytotoxic CD4 and Exhausted-Like CD8+ T-Cells Is a Signature of Active Tuberculosis
[Biochimica Et Biophysica Acta-Molecular Basis Of Disease] Researchers found that lipids from Mycobacterium tuberculosis increased the presence of CD4+ T cells with cytotoxic functions (CD4 CTLs) in DR-TB patients. Our data suggested that active tuberculosis was characterized by exhausted-like CD8+ T cells, which, together with a specific microenvironment, favor the presence of CD4 CTLs.
MR1-Restricted T Cell Clonotypes Are Associated with “Resistance” to Mycobacterium tuberculosis Infection
[JCI Insight] Scientists revealed unexpected donor-specific diversity in the T cell receptor repertoire of human MR1-restricted T (MR1T) cells as well as associations between mycobacteria-reactive MR1T clonotypes and resistance to M. tuberculosis infection.
Immunology of Infectious Disease News was founded to keep the scientific community current with the latest developments in infectious disease research. We feature high-impact publications, news, jobs, and events focused on immune responses to and the development of treatments for infectious diseases such as COVID-19, HIV, hepatitis, tuberculosis, influenza, and malaria.
