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Immunology of Infectious Disease News
Immunology of Infectious Disease News is an online resource dedicated to covering the latest research and developments in the field of infectious diseases.
Dynamic Diversity of SARS-CoV-2 Genetic Mutations in a Lung Transplantation Patient With Persistent COVID-19
[Nature Communications] Researchers described the clinical case of an immunosuppressed host in whom inadequate treatment resulted in highly diverse SARS-CoV-2 mutations that threatened the patient’s health due to the development of drug-resistant variants.
CD8+ T Cell Responses Towards Conserved Influenza B Virus Epitopes Across Anatomical Sites and Age
[Nature Communications] Scientists increased the number of influenza B viruses (IBV) CD8+ T cell epitopes, and defined IBV-specific CD8+ T cells at cellular and molecular levels, across tissues and age.
Nasal Vaccination of Triple-RBD Scaffold Protein With Flagellin Elicits Long-Term Protection Against SARS-CoV-2 Variants Including JN.1
[Signal Transduction And Targeted Therapy] Scientists investigated long-term immune responses and protection against SARS-CoV-2 for the intranasal vaccination of a triple receptor-binding domain (RBD) scaffold protein (3R-NC) adjuvanted with a flagellin protein.
Cervical Microbiota Dysbiosis Associated With High-Risk Human Papillomavirus Infection
[PLOS One] Investigators highlighted the distinctive roles of L. mucosae and L. helveticus in high-risk human papillomavirus infections, signaling a need for further research to demonstrate the potential clinical implications of cervical microbiota dysbiosis.
Viral Entry and Translation in Brain Endothelia Provoke Influenza-Associated Encephalopathy
[Acta Neuropathologica] Researchers showed that influenza virus entered into the cerebral endothelium and thereby induced influenza-associated encephalopathy. Three-weeks-old young mice were inoculated with influenza A virus.
B Cells and Atherosclerosis: A HIV Perspective
[Journal Of Cellular Physiology] The authors review the multifaceted functions of B cells in atherosclerosis, with a specific focus on HIV. Unique to atherosclerosis is the pivotal role of natural antibodies, particularly those targeting oxidized epitopes abundant in modified lipoproteins and cellular debris.
Bird Flu Virus Has Been Spreading in US Cows for Months, RNA Reveals
[Nature] A strain of highly pathogenic avian influenza has been silently spreading in US cattle for months, according to preliminary analysis of genomic data. The outbreak is likely to have begun when the virus jumped from an infected bird into a cow, probably around late December or early January.
Chinese Virologist Who Was First to Share COVID Genome Sleeps on Street After Lab Shuts
[Nature] The first person to publicly release the genome sequence of the virus that causes COVID-19 — virologist Zhang Yongzhen — appears to have resolved a public dispute with the Shanghai Public Health Clinical Center (SPHCC), Fudan University, that erupted last week.
In Vitro Enhancement of Zika Virus Infection by Preexisting West Nile Virus Antibodies in Human Plasma-Derived Immunoglobulins Revealed After P2 Binding Site-Specific Enrichment
[Microbiology Spectrum] Investigators examined a panel of intravenous immunoglobulins manufactured over the past two decades for their capacity to neutralize or enhance Zika virus infection in vitro.
Long COVID: Plasma Levels of Neurofilament Light Chain in Mild COVID-19 Patients With Neurocognitive Symptoms
[Molecular Psychiatry] Researchers investigated the relationship between plasma levels of neurofilament light chain (pNfL) in patients with post-acute neurocognitive symptoms and the potential of NfL as a prognostic biomarker in these cases.
A Phase III Randomized Controlled Trial of a COVID-19 Recombinant Vaccine S-268019-B Versus ChAdOx1 nCoV-19 in Japanese Adults
[Scientific Reports] In this multicenter, randomized, observer-blinded, phase III study, SARS-CoV-2–naïve participants were randomized to receive either S-268019-b or ChAdOx1 nCoV-19 as two intramuscular injections given 28 days apart.
PASC (Post Acute Sequelae of COVID-19) Is Associated With Decreased Neutralizing Antibody Titers in Both Biological Sexes and Increased ANG-2 and GM-CSF in Females
[Scientific Reports] Investigators designed a cross-sectional study to investigate systemic antibody and cytokine responses during COVID-19 recovery and post-acute sequelae of COVID-19.
Immunology of Infectious Disease News was founded to keep the scientific community current with the latest developments in infectious disease research. We feature high-impact publications, news, jobs, and events focused on immune responses to and the development of treatments for infectious diseases such as COVID-19, HIV, hepatitis, tuberculosis, influenza, and malaria.
