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Mammary Cell News
Mammary Cell News is an online resource covering the latest research into breast cancer and mammary cells.
KDM4C Inhibition Blocks Tumor Growth in Basal Breast Cancer by Promoting Cathepsin L-Mediated Histone H3 Cleavage
[Nature Genetics] Scientists described a unique role for the KDM4C histone lysine demethylase in KDM4C-amplified basal breast cancers, where KDM4C inhibition reshapes chromatin and transcriptomic landscapes without substantial alterations of its canonical substrates, trimethylated histone H3 lysine 9 and lysine 36.
Cancer-Associated Fibroblasts Serve As Decoys to Suppress NK Cell Anticancer Cytotoxicity in Breast Cancer
[Cancer Discovery] Using mouse models of breast cancer and ex vivo cocultures, researchers found that cancer-associated fibroblasts inhibit natural killer cell cytotoxicity toward cancer cells.
Dynamic Regulation of Integrin β1 Phosphorylation Supports Invasion of Breast Cancer Cells
[Nature Cell Biology] Investigators engineered a fluorescence resonance energy transfer biosensor for integrin β1 phosphorylation, screening 96 protein tyrosine phosphatases and identifying Shp2 and PTP-PEST as negative regulators to address this gap.
High Prevalence of Constitutional BRCA1 Epimutation in Patients with Early-Onset Triple-Negative Breast Cancer
[Clinical Epigenetics] Scientists assessed BRCA1 epimutation prevalence in a large cohort of 112 early-onset (≤ 30 years-old) TNBC patients with no genetic cancer-predisposing pathogenic variants
Exosomal POU5 F1 Derived from TNBC Promotes Cancer Progression by Regulating M2 Macrophage Polarization via Inhibiting TRAF6 Ubiquitination and Activating AKT in Macrophage
[Cell Biology and Toxicology] Researchers revealed a significant enrichment of the POU domain, class 5, transcription factor 1 (POU5F1) in TNBC cells-derived exosomes.
Nuclear PHGDH Regulates Macrophage Polarization through Transcriptional Repression of GLUD1 and GLS2 in Breast Cancer
[Cancer Biology & Medicine] Investigators revealed a previously unrecognized non-canonical metabolic function of 3-phosphoglycerate dehydrogenase (PHGDH), thus providing potential therapeutic targets in the tumor microenvironment for reversing malignant progression.
Biologically Synthesized Metallic Nanocarriers for Efficient Therapy of Breast Cancer
[Expert Review of Anticancer Therapy] The authors focus on the synthesis of metallic nanoparticles, emphasizing chemical and green synthesis methods as a potential therapeutic platform to enhance breast cancer treatment.
Radiopharm Theranostics Doses First Patient in Phase I ‘HEAT’ Trial of 177lu-RAD202 for Treatment of Advanced HER2-Positive Solid Tumors
[Radiopharm Theranostics] Radiopharm Theranostics announced the dosing of the first patient in its Phase I ‘HEAT’ clinical trial of RAD202, a proprietary nanobody that targets Human Epidermal Growth Factor Receptor 2 (HER2)-positive expression in a wide array of advanced solid tumors.
Targeting of the IL-33/Wnt Axis Restricts Breast Cancer Stemness and Metastasis
[Scientific Reports] Scientists investigated the Interleukin-33 (IL-33)/ST2 axis in breast cancer using CRISPR/Cas9, single-cell RNA sequencing, and murine models. IL-33 overexpression enhanced proliferation, migration, and CSC marker expression in 4T1 and MDA-MB-231 cells, whereas ST2 knockdown via CRISPR or adeno-associated virus attenuated tumor growth and metastasis in vivo, reducing CSC frequency.
Mucinous Breast Cancer Organoids: An In Vitro Research Model
[Discover Oncology] Scientists obtained surgical tumor samples from a 64-year-old Chinese female patient diagnosed with pure mucinous breast cancer to establish patient-derived organoids.
Prophylactic Irradiation of the Contralateral Breast for BRCA Carriers With Early Breast Cancer
[JAMA Oncology] Scientists reported the long-term results of a prospective nonrandomized Phase II trial of prophylactic radiation therapy to the contralateral breast in BRCA pathogenic variant carriers with early breast cancer who forego risk-reducing mastectomy.
Targeting the Dependence on PIK3C3-mTORC1 Signaling in Dormancy-Prone Breast Cancer Cells Blunts Metastasis Initiation
[Cancer Research] The authors suggest that PIK3C3-peripheral lysosomal signaling to mTORC1 may represent a targetable axis for preventing dormant cancer cell–initiated metastasis in patients with breast cancer.
For over a decade, Mammary Cell News has been keeping the global scientific and medical communities informed about the latest research, reviews, and news in the field of mammary tissues. Our editors gather publications on the topic of mammary cell differentiation and characterization, as well as the progression and treatment of breast cancer. We also keep scientists up-to-date on the latest policy changes, job postings, and events.
