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Muscle Cell News
Muscle Cell News is an online resource dedicated to the latest research into smooth, skeletal, and cardiac muscle cells.
Identification of a Resistance-Exercise-Specific Signaling Pathway That Drives Skeletal Muscle Growth
[Nature Metabolism] Using a model of unilateral exercise in male participants and deep phosphoproteomic analyses, researchers find that a prolonged activation of a signaling pathway involving MKK3b/6, p38, MK2 and mTORC1 occurs specifically in response to resistance exercise.
High Resolution Melt Electro-Written Scaffolds Promote Alignment of Human Skeletal Muscle Cells
[Biofabrication] Scientists examined how scaffold fiber orientation influences mechanical properties and cellular behaviour by utilising melt electrowriting as a high-resolution 3D printing technique that combines aspects of electrospinning and melt based polymer deposition.
A Combined Experimental and Computational Analysis of mantATP Turnover in Skinned Muscle Fibers
[Proceedings of The National Academy of Sciences of The United States of America] Researchers combined experimental data and in silico modeling to dissect the contributions of different components in the mantATP chasing signal.
Novel Roles of Nrf3-Trim5 Axis in Vascular Smooth Muscle Cell Dysfunctions and Neointimal Hyperplasia
[Cardiovascular Research] Transcriptome dataset and human atherosclerotic samples were used to determine nuclear factor erythroid 2-related factor 3 (Nrf3) expression levels. Global and vascular smooth muscle cell (VSMC)-specific Nrf3 knockout mice were used to assess the role of Nrf3 in VSMC function and injury-induced neointimal hyperplasia.
Phosphatase-Independent Activity of Smooth-Muscle Calcineurin Orchestrates a Gene Expression Program Leading to Hypertension
[PLOS Biology] By employing newly created smooth muscle cell (SMC)-specific and endothelial cell (EC)-specific calcineurin (Cn)-deficient mice, researchers showed that Cn expressed in SMCs, but not ECs, was required for Ang-II-induced abdominal aortic aneurysm.
FoxO1-zDHHC4-CD36 S-Acylation Axis Drives Metabolic Dysfunction in Diabetes
[Circulation Research] Type 2 diabetes increased cardiac CD36 S-acylation, CD36 sarcolemmal localization, fatty acid oxidation rates, and triglyceride storage in the diabetic heart.
SENP2-Mediated Desumoylation of NCOA4 Protects against Ferritinophagy-Dependent Ferroptosis in Myocardial Ischemia-Reperfusion Injury
[Autophagy] Researchers found that SENP2 expression decreased following myocardial ischemia reperfusion injury. Deletion of SENP2 increased cardiomyocyte ferroptosis and hindered cardiac function recovery after myocardial ischemia-reperfusion injury.
METTL3 Is Essential for Exercise Benefits in Diabetic Cardiomyopathy
[Circulation] Cardiomyocyte-specific N6-adenosine-methyltransferase-like 3 (METTL3) knockout mice and their wild-type littermates were subjected to either chow diet or high-fat diet feeding and injection of streptozotocin to induce diabetic cardiomyopathy.
Dusp14-Mediated Dephosphorylation of MLKL Protects against Cardiomyocyte Necroptosis in Hypothyroidism-Induced Heart Failure
[Circulation] Dual specificity phosphatase 14 (Dusp14) knockout mice were generated, and adeno-associated virus–mediated cardiomyocyte-specific overexpression of Dusp14 was used in combination with related cellular experiments to investigate the protective effects of Dusp14 on hypothyroidism-induced heart failure.
Nicotinamide Riboside Promoted Cardiac Energetics and Alleviated Doxorubicin-Induced Cardiotoxicity via SIRT1/ERRα Signal in Human Pluripotent Stem Cells-Derived Cardiomyocytes
[Life Sciences] Investigators tested the role and mechanism of nicotinamide ribose on hiPSC-differentiated cardiomyocytes under normal and doxorubicin-treated states.
KrüPpel like Factor 7 Regulates Mitochondrial Dynamics Balance in Myocardial Infarction
[Communications Biology] The authors generated cardiomyocyte-specific Klf7 knockout and overexpression mice that underwent myocardial infarction surgery.
Fatty Acid Metabolism Suppresses Neonatal Cardiomyocyte Proliferation by Increasing PDK4 and HMGCS2 Expression through PPARδ
[PLOS One] Scientists investigated how fatty acid metabolism contributes to cell cycle regulation in neonatal cardiomyocytes. Cultured neonatal rat cardiomyocytes were treated with a fatty acid mixture consisting of palmitic and oleic acids containing L-carnitine.
Every day, our editorial team sifts through the most recent scientific literature to help keep researchers and medical professionals current. Muscle Cell News covers the three types of muscle cells: cardiac, skeletal, and smooth muscle. We cover a broad range of topics, including cell culturing, muscle regeneration, and musculoskeletal disorders.
