Muscle Cell News

Muscle Cell News is an online resource dedicated to the latest research into smooth, skeletal, and cardiac muscle cells.

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FHOD3 Deficiency Disrupts Sarcomere Organization and Activates caMKII Signaling in Human Stem Cell-Derived Cardiomyocytes

January 26, 2026

[Stem Cell Research & Therapy] Researchers established a valuable human-derived model for investigating the molecular mechanisms of FHOD3 deficiency-induced cardiomyopathy.

Microgroove and Cyclic Stretch-Based Stem Cell Gym Enhance Maturation of Human iPSC-Derived Cardiomyocytes

January 26, 2026

[Annals of Biomedical Engineering] Scientists indicated that hiPSC-cardiomyocytes exhibit increased cellular elongation, sarcomere length, and expression of cardiac troponin T when cultured on 10–50 μm microgroove substrates.

Exercise Mitigates IL-27-Induced Muscle Atrophy Following Myocardial Infarction through Anti-Inflammatory Mechanisms

January 26, 2026

[Journal of Translational Medicine] The authors provide insights into the mechanisms of myocardial infarction-induced muscle atrophy and highlight the therapeutic potential of exercise in cardiac rehabilitation.

ASB5 Is a Specific Marker for Muscle Satellite Cells but Dispensable for Skeletal Muscle Development and Regeneration

January 26, 2026

[Skeletal Muscle] Investigators surveyed single-cell RNA-seq data to identify ankyrin repeat and suppressor of cytokine signaling Box containing 5 (ASB5) as a marker of muscle satellite cells.

ACTA2 Pathogenic Variants Activating Heat Shock Factor 1 and Increasing Cholesterol Biosynthesis in Smooth Muscle Cells Predispose to Early Onset Atherosclerosis

January 26, 2026

[Circulation] The molecular pathway linking misfolded α-smooth muscle actin monomers to augmented atherosclerosis–associated smooth muscle cell phenotypic modulation can be modeled in vitro by stably expressing the ACTA2 p.R149C variant in Acta2^−/− smooth muscle cells.

FGF12 Induces Aberrant Mechanosignaling in Aortic Smooth Muscle Cells during Thoracic Aortic Aneurysm Formation in Marfan Syndrome Mice

January 26, 2026

[Experimental & Molecular Medicine] Fibroblast growth factor 12 (FGF12) is markedly upregulated in aortic smooth muscle cells of thoracic aneurysmal aortas from Fbn1^C1039G/+ Marfan syndrome (MFS) mice and from patients with MFS.

Immunometabolic Reprogramming of Macrophages: Emerging Roles in Skeletal Muscle Regeneration and Therapeutic Perspectives

January 26, 2026

[Pharmacological Research] The authors provide a comprehensive summary of how macrophage immunometabolism regulates skeletal muscle regeneration in both acute injury and chronic disease.

Dyne Therapeutics Receives Orphan Drug Designation in Japan for Zeleciment Basivarsen (DYNE-101) for Myotonic Dystrophy Type 1

January 26, 2026

[Dyne Therapeutics, Inc.] Dyne Therapeutics, Inc. announced that the Ministry of Health, Labour and Welfare in Japan has granted Orphan Drug designation for zeleciment basivarsen, for the treatment of myotonic muscular dystrophy type 1.

Necessity of Notch3 Signaling in Myofiber Maturation in a Pluripotent Stem Cell Transplant Model

January 14, 2026

[Skeletal Muscle] Since a role for Notch3 in skeletal muscle maturation is unknown, the authors investigated whether Notch3 is required for this in vivo molecular maturation switch.

Inhibition of TREM1 Attenuates Myocardial Ischemia-Reperfusion Injury-Induced Cardiomyocyte Pyroptosis by Suppressing the Activation of the NF-κB Signaling Pathway

January 12, 2026

[PloS One] Scientists investigated the role of TREM-1 in myocardial I/R injury and to explore the potential underlying molecular mechanisms.

Inhibiting L-Type Calcium Channel Promotes Cardiomyocyte Proliferation through Activating the Canonical Wnt Signaling Pathway

January 12, 2026

[Acta Pharmacologica Sinica] Researchers developed a high-content screening assay based on DNA synthesis in human pluripotent stem cell-derived cardiomyocytes (CMs) to identify small molecules that could promote CM proliferation.

Investigating the Role of EGFR Signalling in Muscle Dystrophies: Implications for Duchenne Muscular Dystrophy

January 12, 2026

[Cell Death & Disease] Investigators used datasets from single-nuclei RNA sequencing of Duchenne Muscular Dystrophy muscle samples to study the dysregulation of molecular pathways compared to healthy control muscle.

Every day, our editorial team sifts through the most recent scientific literature to help keep researchers and medical professionals current. Muscle Cell News covers the three types of muscle cells: cardiac, skeletal, and smooth muscle. We cover a broad range of topics, including cell culturing, muscle regeneration, and musculoskeletal disorders.