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Muscle Cell News
Muscle Cell News is an online resource dedicated to the latest research into smooth, skeletal, and cardiac muscle cells.
Early-Stage Morphogenesis of T-Tubules in Rat Cardiomyocytes: The Role of pBIN1
[Circulation Research] To understand early-stage morphogenesis of cardiac transverse tubules (TTs), researchers utilized a scanning electron microscope equipped with a focused ion beam to reconstruct a 3-dimensional spatial profile of the developing TT network in cardiomyocytes from 2-week-old rats.
Insights into tissue- and Cell Type-Specific Effects of Grb10 on Pig Skeletal Muscle Growth by Multi-Omics Analysis
[Science China Life Sciences] Researchers identified the specificity of GRB10 in muscle tissue and cells between obese and lean pigs by combining genomics, transcriptomics, epigenomics, and single-cell transcriptomics.
Cardiomyocyte Growth on Cardiac Infusible Extracellular Matrix-Coated and Annealed Biodegradable Polyurethane Fibers
[Langmuir] Investigators explored strategies to mitigate shrinkage and enhance the functionality of polyurethane fibers for the cardiac cell culture.
Premature Cell Senescence Promotes Vascular Smooth Muscle Cell Phenotypic Modulation and Resistance to Re-Differentiation.
[Cardiovascular Research] DNA damage and senescence induce genes associated with de-differentiated/fibromyocytic vascular smooth muscle cells, and persistence of these cells in vivo.
VSMCs in Atherosclerosis: Implications on the Role of Inflammation and Extracellular Matrix Remodelling
[Pharmacological Research] The authors summarize the current understanding of vascular smooth muscle cells in atherosclerosis, focusing on their origin, plasticity, phenotype switching, and role at different stages of atherosclerosis.
Capricor Therapeutics Announces Orphan Drug Designation for Becker Muscular Dystrophy and Regulatory Progress for Duchenne Muscular Dystrophy Program
[Capricor Therapeutics] Capricor Therapeutics announced that the US FDA has granted Orphan Drug Designation to Deramiocel, the company’s lead cell therapy candidate, for the potential treatment of Becker Muscular Dystrophy.
SMURF2 Inhibition Attenuates Cardiac Hypertrophy through Blocking Ubiquitination Degradation of AXIN1
[Acta Pharmacologica Sinica] Scientists investigated the regulatory role of SMURF2 in cardiac hypertrophy. Experiment models were established in mice by transverse aortic constriction in vivo, as well as in neonatal rat cardiomyocytes by treatment with angiotensin II in vitro.
Circ‐myh8/KAT7 Affects PANoptosis in Pulmonary Arterial Smooth Muscle Cells: Involvement of Super‐Enhancers in FOSL2 Expression
[Journal of The American Heart Association] Chromatin immunoprecipitation‐sequencing was integrated with RNA sequencing to identify super‐enhancer‐regulated target genes in hypoxic pulmonary arterial smooth muscle cells.
SiRNA-Mediated Knockdown of TOP2B Protects hiPSC-Derived Cardiomyocytes from Doxorubicin-Induced Toxicity.
[Life Sciences] hiPSC-derived cardiomyocytes were treated with siRNA to knock down tTopoisomerase-2 beta and were then exposed to doxorubicin.
The Contribution of Cardiomyocyte Hypercontracture to the Burden of Acute Myocardial Infarction: An Update.
[Basic research in cardiology] Scientists review the pathogenesis and clinical manifestation of hypercontracture in cardiomyocytes during acute myocardial infarction.
$60M Donation Will Fund Cardiovascular Institute at Vancouver General Hospital
[CBC] The head cardiologist at Vancouver General Hospital says a $60 million donation toward a new cardiovascular health institute and innovation fund will have a life-saving impact around the world.
Spatio-Temporal Calcium Signaling Patterns Underlying Opposing Effects of Histamine and TAS2R agonists in Airway Smooth Muscle
[American Journal of Physiology-Lung Cellular and Molecular Physiology] The authors investigated the spatio-temporal dynamics of Ca2+ signaling in airway smooth muscle (ASM) cells using single-cell microscopy and deep learning-based segmentation, integrating the results into a comprehensive model of ASM ion channel dynamics to compare the effects of histamine, CQ, and flufenamic acid.
Every day, our editorial team sifts through the most recent scientific literature to help keep researchers and medical professionals current. Muscle Cell News covers the three types of muscle cells: cardiac, skeletal, and smooth muscle. We cover a broad range of topics, including cell culturing, muscle regeneration, and musculoskeletal disorders.
