Intracellular Calcium Leak in Heart Failure and Atrial Fibrillation: A Unifying Mechanism and Therapeutic Target

The authors focus on the mechanisms that regulate ryanodine receptor 2 (RYR2), the major sarcoplasmic reticulum Ca2+-release channel in the heart, and how RYR2 becomes dysfunctional in heart failure and atrial fibrillation.
[Nature Reviews Cardiology]
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The Importance of the ZBED6-IGF2 Axis for Metabolic Regulation in Mouse Myoblast Cells

Scientists showed a significant enrichment of mitochondrial membrane proteins among proteins showing altered expression in Zbed6−/− myoblasts.
[FASEB Journal]
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Modulation of Mammalian Cardiomyocyte Cytokinesis by the Extracellular Matrix

Direct co-culture with postnatal cardiac fibroblasts increased cardiomyocyte binucleation, which could be inhibited by RGD peptide treatment.
[Circulation Research]
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Reactive Oxygen-Forming Nox5 Links Vascular Smooth Muscle Cell Phenotypic Switching and Extracellular Vesicle-Mediated Vascular Calcification

In vitro cultures of synthetic vascular smooth muscle cells (VSMCs) showed decreased expression of contractile markers CNN1, αSMA and SM22α and an increase in synthetic marker S100A4 compared to contractile VSMCs.
[Circulation Research]
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Searching for Novel Hydrogen Sulfide Donors: The Vascular Effects of Two Thiourea Derivatives

In human aortic smooth muscle cells, diphenylthiourea caused membrane hyperpolarization, mediated by activation of KATP and Kv7 potassium channels.
[Pharmacological Research]
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LncRNA LBX2-AS1 Facilitates Abdominal Aortic Aneurysm through miR-4685-5p/LBX2 Feedback Loop

The effects of dysregulated ladybird homeobox 2 antisense RNA 1 or ladybird homeobox 2 on vascular smooth muscle cell biological processes were surveyed via cell counting kit-8, methyl thiazolyl tetrazolium, terminal-deoxynucleoitidyl transferase mediated nick end labeling and caspase-3 activity assays.
[Biomedicine & PharmacoTherapy]
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FOXO3a-Mediated Long Non-Coding RNA LINC00261 Resists Cardiomyocyte Hypoxia/Reoxygenation Injury via Targeting miR23b-3p/NRF2 Axis

The expression of LINC00261 was significantly down-regulated in myocardial tissues and H9C2 cells. Overexpression of LINC00261 improved cardiac function and reduced myocardium apoptosis.
[Journal of Cellular and Molecular Medicine]
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Sarepta Therapeutics and Selecta Biosciences Enter Into Research License and Option Agreement for Selecta’s ImmTOR Immune Tolerance Platform in Neuromuscular Diseases

Sarepta Therapeutics, Inc. and Selecta Biosciences, Inc. announced that they have entered into a research license and option agreement granting Sarepta an option to license the rights to develop and commercialize Selecta’s immune tolerance platform for use in Duchenne muscular dystrophy and certain limb-girdle muscular dystrophies.
[Sarepta Therapeutics, Inc.]
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Human Umbilical Cord Blood–Derived MSCs Exosome Attenuate Myocardial Injury by Inhibiting Ferroptosis in Acute Myocardial Infarction Mice

Compared with sham or normoxia groups, RT-PCR and western blotting showed that divalent metal transporter 1 expression was significantly increased, and Prussian blue staining, ferrous iro, MDA, and GSH level detection demonstrated that ferroptosis occurred in the infraction myocardium and in cardiomyocyte following hypoxia-induced injury.
[Cell Biology and Toxicology]
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Autism-Associated SHANK3 Mutations Impair Maturation of Neuromuscular Junctions and Striated Muscles

Investigators used a combination of patient-derived human iPSCs, Shank3Δ11(−/−) mice, and Phelan-McDermid syndrome muscle biopsies from patients of different ages to analyze the role of SHANK3 on motor unit development.
[Science Translational Medicine]
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Human MuStem Cell Grafting into Infarcted Rat Heart Attenuates Adverse Tissue Remodeling and Preserves Cardiac Function hMuStem Cells Preserve Function of Infarcted Heart

In Dog and Human, the authors described a type of muscle-derived stem cells termed MuStem cells that efficiently promoted repair of injured skeletal muscle. Enhanced survival rate, long-term engraftment, and participation in muscle fiber formation were reported, leading to persistent tissue remodeling and clinical benefits.
[Molecular Therapy-Methods & Clinical Development]
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