Inhibition of CDK7 Mitigates Doxorubicin Cardiotoxicity and Enhances Anticancer Efficacy

Doxorubicin (DOX) exposure induced CDK7 activation in mouse heart and isolated cardiomyocytes. Cardiac-specific ablation of cyclin-dependent kinase 7 (CDK7) attenuated DOX-induced cardiac dysfunction and fibrosis.