Neural Cell News

Neural Cell News is an online resource covering the latest research in neuroscience, neural stem cells, and neurological conditions.

Generation of Neural Organoids for Spinal-Cord Regeneration via the Direct Reprogramming of Human Astrocytes

[Nature Biomedical Engineering] The authors showed that human astrocytes could be directly reprogrammed into early neuroectodermal cells via the overexpression of OCT4, the suppression of p53 and the provision of the small molecules CHIR99021, SB431542, RepSox and Y27632.

Mitochondrial Dysfunction of Induced Pluripotent Stem Cells-Based Neurodegenerative Disease Modeling and Therapeutic Strategy

[Frontiers in Cell and Developmental Biology] Scientists summarize the iPSC modeling approach of Alzheimer’s disease, Parkinson’s disease, and Amyotrophic lateral sclerosis, as well as outline typical mitochondrial dysfunction and recapitulate corresponding therapeutic strategies.

Superenhancer-Activation of KLHDC8A Drives Glioma Ciliation and Hedgehog Signaling

[Journal of Clinical Investigation] Scientists interrogated superenhancer landscapes of primary glioblastoma specimens and patient-derived GSCs, revealing a kelch domain-containing gene (KLHDC8A) with a previously unknown function as an epigenetically-driven oncogene.

Chronic Oligodendrocyte Injury in Central Nervous System Pathologies

[Communications Biology] The authors cover the range of injury to oligodendrocytes (OLs) and intrinsic versus extrinsic influences, and reflect on how this knowledge may be harnessed for therapeutic development.

Microglia and Metastases to the Central Nervous System: Victim, Ravager, or Something Else?

[Histology and Histopathology] Investigators compare the view on microglia plasticity based on classical studies and on high-resolution ‘omic’ analyses to better understand their role in brain metastases and their impact on this complex multidimensional microenvironment.

Medin Co-aggregates with Vascular Amyloid-β in Alzheimer’s Disease

[Nature] Researchers demonstrated in amyloid-β precursor protein transgenic mice and in patients with Alzheimer’s disease that medin co-localized with vascular amyloid-β deposits, and that in mice, medin deficiency reduced vascular amyloid-β deposition by half.

Brain-Targeted HFn-Cu-REGO Nanoplatform for Site-Specific Delivery and Manipulation of Autophagy and Cuproptosis in Glioblastoma

[Small] Human H-ferritin (HFn), regorafenib (REGO), and Cu2+ were rationally designed as a brain-targeted nanoplatform, fulfilling the task of site-specific delivery and manipulating autophagy and cuproptosis against glioblastoma multiforme.

Ketamine Impairs Growth Cone and Synaptogenesis in Human GABAergic Projection Neurons via GSK-3β and HDAC6 Signaling

[Molecular Psychiatry] Using human GABAergic projection neurons derived from human inducible pluripotent stem cells and embryonic stem cells in vitro, we tested ketamine effects on the growth cones and synapses in developing GABAergic neurons by assessing the morphometry and the glycogen synthase kinase-3 (GSK-3) and histone deacetylase 6 (HDAC6) pathway.

The CRHR1/CREB/REST Signaling Cascade Regulates Mammalian Embryonic Neural Stem Cell Properties

[EMBO Reports] Researchers showed that CRHR1 is required for the maintenance of neural stem cell properties, as assessed by in vitro neurosphere assays and cell distribution in the embryonic cortical layers following in utero electroporation.

The Role of Tyrosine Hydroxylase–Dopamine Pathway in Parkinson’s Disease Pathogenesis

[Cellular and Molecular Life Sciences] Investigators highlighted the important role of the tyrosine hydroxylase–dopamine pathway in the pathogenesis of Parkinson's disease.

Neurotoxicity of Diesel Exhaust Extracts in Zebrafish and Its Implications for Neurodegenerative Disease

[Scientific Reports] Scientists investigated the impact of diesel exhaust particulate extract exposure on the brain and the mechanisms by which microglia and astroglia might mediate neuronal changes.

Age- and Cell Cycle-Related Expression Patterns of Transcription Factors and Cell Cycle Regulators in Müller Glia

[Scientific Reports] Investigators analyzed protein expression of retinal progenitor cell transcription factors and cell cycle regulators in rodent Müller glia in vivo and in vitro, focusing on their age- and cell-cycle-related expression changes.

Neural Cell News helps scientists keep pace with the latest research, reviews, and industry developments in neuroscience. Specific research topics include neural development and neuroregeneration, neural signaling related to cellular responses and behavior, and synaptic plasticity. Research into the diagnosis, progression, cellular characteristics, and treatment of brain diseases such as Parkinson’s, Multiple Sclerosis, Alzheimer’s, Amyotrophic Lateral Sclerosis and various brain cancers, as well as brain damage resulting from infection, trauma, stroke, seizures, and tumors, is also covered.

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