Neural Cell News

Neural Cell News is an online resource covering the latest research in neuroscience, neural stem cells, and neurological conditions.

Defining Blood-Induced Microglia Functions in Neurodegeneration through Multiomic Profiling

[Nature Immunology] Researchers established an unbiased blood-innate immunity multiomic and genetic loss-of-function pipeline to define the transcriptome and global phosphoproteome of blood-induced innate immune polarization and its role in microglia neurotoxicity.

Effects of Acute Low-Moderate Dose Ionizing Radiation to Human Brain Organoids

[PLOS One] The authors generated brain/cerebral organoids from human iPSCs to study the radiosensitivity of human brain cells, including neurons, astrocytes, and oligodendrocytes.

Advances in Stem Cell and Other Therapies for Huntington’s Disease: An Update

[Brain Research Bulletin] The authors summarize the recent research in stem cells, genetic modifications, and organoids as a potential for treatment of Huntington’s disease.

Non-Invasive Approach for Electrical Nerve Stimulation Among Six Projects Supported by 2023 Connaught Innovation Awards

[University of Toronto Engineering News] Professor Paul Yoo had been designing novel electrodes for non-invasive electrical nerve stimulation, a technology that could be used in therapies for the treatment of epilepsy, depression, Parkinson’s disease, and many pain disorders.

UTHealth Houston Receives Federal Funding for Traumatic Brain Injury Research

[UTHealth Houston] Nearly $13 million in federal grant funds to study treatments for traumatic brain injury was awarded to UTHealth Houston by the Department of Defense’s Office of Congressionally Directed Medical Research Programs.

Antigen Recognition Detains CD8+ T Cells at the Blood-Brain Barrier and Contributes to Its Breakdown

[Nature Communications] Investigators showed that brain endothelial cells process and cross-present antigen, leading to effector CD8+ T cell differentiation. Under physiological flow in vitro, endothelial antigen presentation prevented CD8+ T cell crawling and diapedesis resulting in brain endothelial cell apoptosis and blood-brain barrier breakdown.

Microcephaly-Associated Protein WDR62 Shuttles From the Golgi Apparatus to the Spindle Poles in Human Neural Progenitors

[eLife] Scientists investigated WDR62 function in corticogenesis through the analysis of a C-terminal truncating mutation. They generated 2D and 3D models of human neurodevelopment, including neuroepithelial stem cells, cerebro-cortical progenitors, terminally differentiated neurons, and cerebral organoids.

Activated SIRT1 Contributes to DPT-Induced Glioma Cell Parthanatos by Upregulation of NOX2 and NAT10

[Acta Pharmacologica Sinica] Researchers investigated the role of SIRT1 in deoxypodophyllotoxin (DPT)-induced human glioma cell parthanatos. They showed that DPT activated both polymerase 1 and SIRT1, and induced parthanatos in U87 and U251 glioma cells.

Enhancing the Neuroprotective Effect of Squid Outer Skin Astaxanthin Against Rotenone-Induced Neurotoxicity in In-Vitro Model for Parkinson’s Disease

[Food And Chemical Toxicology] Scientists evaluated the effect of astaxanthin in preventing rotenone-induced toxicity of SK-N-SH human neuroblastoma cells in an in vitro model of experimental Parkinsonism.

Saikosaponin B2 Ameliorates Depression-Induced Microglia Activation by Inhibiting Ferroptosis-Mediated Neuroinflammation and ER Stress

[Journal Of Ethnopharmacology] Investigators evaluated the anti-inflammatory effect and elucidated underlying molecular mechanisms of saikosaponins B2 in lipopolysaccharide-induced primary microglia and chronic unpredictable mild stress-induced mice model of depression.

Lemur Tyrosine Kinase 2 Has a Tumor-Inhibition Function in Human Glioblastoma by Regulating the RUNX3/Notch Pathway

[Biochimica Et Biophysica Acta-Molecular Cell Research] A suppressive function of lemur tyrosine kinase 2 (LMTK2) on the proliferative capability and metastatic potential of glioblastoma (GBM) cells was demonstrated by overexpressing LMTK2 in GBM cell lines.

1,25-Dihydroxy Vitamin D3 Facilitates the M2 Polarization and β-Amyloid Uptake by Human Microglia in a TREM2-Dependent Manner

[Biomed Research International] Researchers treated human microglial cells with Aβ to mimic in vivo microglial activation and neuroinflammation in response to Aβ accumulation, which are the main pathological features of Alzheimer’s disease, and examined the potential immunomodulatory effects of 1,25(OH)2D3 in vitro.

Neural Cell News helps scientists keep pace with the latest research, reviews, and industry developments in neuroscience. Specific research topics include neural development and neuroregeneration, neural signaling related to cellular responses and behavior, and synaptic plasticity. Research into the diagnosis, progression, cellular characteristics, and treatment of brain diseases such as Parkinson’s, Multiple Sclerosis, Alzheimer’s, Amyotrophic Lateral Sclerosis and various brain cancers, as well as brain damage resulting from infection, trauma, stroke, seizures, and tumors, is also covered.